Angiographic profile of NSTEMI patients with or without metabolic syndrome (original) (raw)
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Background: Metabolic syndrome (MetS) is a cluster of metabolic traits that confer high risk for coronary artery disease (CAD). This study aimed to assess the relationship between MetS components and severity of CAD . Methods : Eighty six patients underwent elective coronary angiography, calculation of the metabolic risk score and laboratory evaluation. Patients divided into two groups according to the presence of MetS: group A; 64 patients with ? 3MetS components and group B; 22 patients with< 3 components. Assessment of CAD severity using Gensini score. Results:- There were significant difference between the both groups concerning body mass index, high blood pressure, triglyceride, high density lipoprotein, fasting blood glucose (FBG), serum insulin, insulin resistance and Genseni score (P < 0.05) . Significant positive correlation between MetS score and Genseni score (P< 0.000). Multivariate analysis showed that MetS itself did not predict the presence of CAD (p= 0.49), howevere some individual component of MetS show significant predictive value; namely, high FBG > 110 mg/dl ( OR 23.748, p<0.001), high TGs > 150 mg/dl (OR 7.35, p =0.012) and high blood pressure( OR 6.07, p= 0.02). Conclusion: - Fasting blood glucose, high triglyceride and blood pressure were independent predictors CAD rather than metabolic syndrome itself. FBG was the most independent factor that predicts CAD.
Coronary Artery Disease in Patients with Metabolic Syndrome
2017
Background: Metabolic syndrome (MS) has been reported to be associated with coronary artery disease (CAD). Objective: The purpose of this study was to evaluate the presence of CAD in patients with MS, and to compare each component of the syndrome in patients with and without CAD. Methods: 205 patients with MS who underwent elective coronary angiography were enrolled in the study. MS was defined according to National Cholesterol Education Program (NCEP)/Adult Treatment Panel III criteria. All patients were divided in two groups according to the presence of CAD. Results: The proportion of MS patients with CAD was significantly higher compared to those without CAD (72.68% vs. 27.32%, p<0.001). Patients with CAD had higher levels of fasting blood glucose (78.50% vs. 46.40%, p<0.001) and lower levels of HDL-cholesterol (74.03% vs. 25.97%, p<0.001). There was no significant difference between the two groups regarding triglycerides levels (75.80% vs. 80.40%, p=0.493). Patients wit...
PloS one, 2015
Although metabolic syndrome is associated with increased risk of cardiovascular disease and events, its added prognostic value beyond its components remains unknown. This study compared the prevalence, severity of coronary artery disease (CAD), and prognosis of patients with metabolic syndrome to those with individual metabolic syndrome components. The study cohort consisted of 27125 consecutive individuals who underwent ≥64-detector row coronary CT angiography (CCTA) at 12 centers from 2003 to 2009. Metabolic syndrome was defined as per NCEP/ATP III criteria. Metabolic syndrome patients (n=690) were matched 1:1:1 to those with 1 component (n=690) and 2 components (n=690) of metabolic syndrome for age, sex, smoking status, and family history of premature CAD using propensity scoring. Major adverse cardiac events (MACE) were defined by a composite of myocardial infarction (MI), acute coronary syndrome, mortality and late target vessel revascularization. Patients with 1 component of m...