Kir3 channel blockade in the cerebellar cortex suppresses performance of classically conditioned Purkinje cell responses (original) (raw)

AI-generated Abstract

In this study, the role of Kir3 channels in the cerebellar cortex was examined in the context of classical eyeblink conditioning. The antagonist Tertiapin-LQ was applied locally to assess its effects on Purkinje cell responses, specifically the conditioned pause in firing elicited by a conditional stimulus. Results showed that blockade of Kir3 channels led to a significant suppression of this conditioned response without affecting spontaneous firing, indicating the necessity of functional Kir3 channels for normal Purkinje cell behavior during conditioning.

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