1,1,2-Trichlorethan. MAK-Begründung, Nachtrag (original) (raw)

The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated the maximum concentration at the workplace (MAK value) and the Pregnancy Risk Group of 1,1,2-trichloroethane [79-00-5]. The critical effects are local irritation after inhalation or dermal exposure and liver toxicity after oral administration. Inhalation of 15 ml/m 3 leads to vacuolization of the olfactory epithelium after 13-week exposure of rats. A NAEC of 5 ml/m 3 was calculated. As a result of the local irritation, the MAK value has been lowered to 1 ml/m 3. As the critical effect of 1,1,2-trichloroethane is local, Peak Limitation Category I has been assigned. The excursion factor of 2 is retained. 1,1,2-Trichloroethane is classified in Pregnancy Risk Group D because sufficient data for developmental toxicity are not available. 1,1,2-Trichloroethane is still a suspected carcinogen and remains in Carcinogen Category 3 B. 1,1,2-Trichloroethane can be absorbed via the skin in toxicologically relevant amounts and remains designated with "H". A sensitizing potential is not expected from the data available.