Effect of Acute Dose of Aloe vacillans Leaves Gel Extract on The Liver and Kidney in Adult Rats (original) (raw)
Related papers
2016
Background: Aloe vera gel is one of several nutritional supplements gaining widespread popularity in Nigeria and many other countries of the world. Adverse effects of ingestion of low doses of Aloe vera are seldom reported. It has however, been associated with diarrhea, electrolyte imbalance, kidney dysfunction, and hepatitis. The aim of this study is to investigate the effects of oral administration of GLND'S Aloe vera Plus on the kidneys and hearts of rats. Methods: 80 apparently healthy, adult Wistar albino rats were divided into five groups, three of which were given three different doses of Aloe vera plus twice a day for 14, th28 and 42 days. The 4 group served as controls while the 5th was given Aloe vera plus for 28 days, following which the drug was withdrawn for another 28 days. The animals were sacrificed at the end of the experiment and the hearts and kidneys harvested for histopathological analysis. Results: The results indicate that Aloe vera plus caused nephrotoxi...
2022
Background: Several local communities in Central, Western, Eastern, and Northern regions of Uganda have been using the whole leaf extracts of Aloe vera (L.) Burm. f. (Asphodelaceae) in the treatment of various ailments. Also, several commercial companies sell A. vera as soft drinks in Uganda. However, there are inadequate reports on the toxicities of such preparations. This paper reports the acute and sub-acute oral toxicity of aqueous extracts of whole leaf and green rind of A. vera in Wistar rats. Methods: Acute oral toxicity test was carried out in female Wistar rats at doses of 175, 550, 1750, and 5000 mg/kg, p.o. The animals were observed for signs of toxicity for 14 days. Similarly, a sub-acute oral toxicity test was performed in both sexes of rats at doses of 200, 400, and 800 mg/kg, p.o. daily for 28 days. All the groups of animals were monitored for behavioral, morphological, biochemical, and physiological changes, including mortality and compared with respective controls. Body weights were measured weekly while the animals' relative organ weights, hematological, biochemical, gross, and microscopic pathology were examined on day 29. Results: There was no mortality or apparent behavioral changes at the doses tested in acute and sub-acute oral toxicity tests. Thus, the Median Lethal Dose (LD 50) of green rind and whole leaf aqueous extracts was above 5000 mg/kg. Gross anatomy revealed that the rats' relative spleen weight in green rind extract at 200 mg/kg significantly decreased compared to the control group. The creatinine levels in female rats that received green rind extract and the chloride ion levels in male rats administered whole leaf extract were significantly elevated. Conversely, Mean Corpuscular Hemoglobin Concentration (MCHC) levels significantly decreased at lower doses of the green rind extract compared to the control. Histopathology of the kidney revealed the renal interstitium's inflammation at doses of 200 and 800 mg/kg of the whole leaf extract. Conclusion: The findings demonstrated that A. vera green rind and whole leaf extracts are non-toxic at relatively high doses when used for a short duration. Prolonged use of the aqueous whole leaf extract might be associated with kidney toxicity.
Phytochemistry, health benefits and toxicological profile of aloe
2019
Aloe is a perennial succulent of Liliaceae family and long been recognised for diverse medicinal preparations, extraction of drug and flavouring liquors. The exact origin of Aloe is uncertain, but is mainly grown in relatively warm and dry climate Two major products derived from the leaves are the yellow bitter juice consisting of aloin and the gel rich in polysaccharides. It also includes vitamins, enzymes, anthraquinones/anthrones, chromones and many other primary as well as secondary metabolites. These are extensively used as active ingredients in laxative and in anti-obesity medicines, as emollient or wound healer in various cosmetic and pharmaceutical formulations. Many tribals have their own indigenous formulations from Aloe species to manage various ailments since ages. However, in spite of scores of beneficial role, sometimes a few chemicals present in Aloe make the products toxic which, of course, depends on the source, locality, person to be used, etc. The present study ex...
Aloe: medicinal properties and botanical characteristics
Journal of Current Science and Technology, 2022
Aloe plants have been studied and used to treat many diseases for thousands of years. Since ancient times it has been used to cure human ailments. Over the last few decades, several studies have shed light on the characteristics of this plant, which seems to want to hide its secrets behind botanical and pharmacological riddles that are only now beginning to be answered. The medicinal abilities of Aloe plants have been known to man since ancient times. Therefore, we can consider Aloe a food and medicine: if you decide to take Aloe, know that you have opted for complete food. Aloe plants are a reservoir of important substances for the human body, particularly vitamins, catalyzing enzymes, sugars and medicinal oils. The German Pharmacopoeia, in its 1873 edition, at the time of Bismark, already recorded more than 300 pharmaceutical elements contained in Aloe. Modern medical literature confirms this today, with lists and lists of such ingredients, the result of research by laboratories working honestly, objectively seeking the truth. Studies show the presence of certain secondary metabolites in Aloe that can cause problems. In particular, the presence of aloin, in Aloe vera, is a compound that can be metabolised by the human gut and can cause various harmful effects such as carcinogenic, genotoxic, nephrotic and digestive problems. The presence of certain alkaloids and polysaccharides are also reported to cause liver and reproductive problems. This paper examines the botanical, cultivation and medicinal properties associated with this very important plant.
Effect of Aloe-Vera on Liver Functions in Dog
Pakistan Journal of Medical and Health Sciences
Aloe vera is one of the most important plant used in modern science and has gained popularity in homeopathy and conventional medicine. Recent studies on rodents have shown its effect on liver. Therefore, current study was planned to assess the effects of Aloe Vera gel on liver function in normal and induced hyperglycaemic dogs. Aloe Vera gel was administrated orally in dogs (n = 12). The experimental period was divided into two phases. In each phase dogs were divided into three group’s i-e., A, B and C. In phase-1, group A was given only basal diet and kept as a control. Whereas group B was treated with Aloe vera gel at the therapeutic dosage of 500mg/kg B.W with basal diet, while group C was treated higher dosage regimen of 1000mg/kg B.W with basal diet once daily for 07 consecutive days. After 21 days washout period, in Phase-2, group A was fed basal with high carbohydrate diet and kept as a control. Whereas group B and C was administered Aloe vera gel at therapeutic dosage regime...
Medicinal Applications and Toxicological Activities of Aloe . Products
Pharmaceutical Biology, 2007
Aloe (Lilliaceae) has long been used as a remedy in many cultures. Aloe products, which include the latex, gel, and whole leaf, are used, among other reasons, as laxatives, in creams for skin ailments, and as a treatment for a wide range of diseases, respectively. The heterogeneous nature of Aloe products may contribute to the diverse biological and therapeutic activities that have been observed. Variations in the composition of Aloe can result in products with different chemical and physical properties, making the comparison of products difficult. In this article, the chemistry, uses, pharmacological activity, and toxicity of Aloe gel, latex, and isolated compounds are reviewed. This article is confined to literature pertaining to Aloe vera (L.) Burm.f. (also known as A. barbadensis Miller) and Aloe ferox Miller since they are the most widely used species both commercially and for their therapeutic properties.
The study was conducted to investigate the safety of combined extracts of Bryophyllum pinnatum (family: Crassulaceae) and Aloe barbadensis (family: Xanthorrhoeaceae) in rats. Forty rats were randomly selected and divided into four groups. Rats in groups I were administered with placebo as the control animals, while rats in groups II, III and IV were administered with aqueous extracts at 25mg/ml, 50mg/ml and 100mg/ml respectively for 28 days. Five milliliter (5ml) of blood was collected from either the ocular vein or aorta of each animal for evaluation of baseline and post – treatment values of AST, ALP, ALT, BUN, Total protein, and Creatinine, WBC, RBC, Platelet, MCV, MCH and MCHC. Data were expressed as Mean±Standard Error of Mean and analyzed using oneway ANOVA. Difference of means was considered statistically significant at P<0.05. Quantitative phytochemical assay revealed mainly alkaloids, with one gram each of B. pinnatum and A. barbadensis extracts containing 5.3mg and 9.1mg of alkaloids respectively. Administration of the combined extracts elevated the serum levels of Alkaline phosphatase, Aspartate amino transaminase, Total protein, Creatinine and BUN in the entire rats in test groups especially those in group IV (P<0.05). In ALT, there was no significant variation between the baseline and the post-treatment values especially in animals in groups III and IV (P>0.05). Rats in groups II, III and IV exhibited significant increase in values of WBC, RBC, Platelet, MCV and MCH (P<0.05) while MCHC value for rats in group IV showed insignificant differences when compared to the control rats (P>0.05). Administration of the combined extracts may be tolerated at ≤25mg/kg bodyweight, if prolonged administration is avoided.
Asian Journal of Medical Sciences, 2014
Background: Aloe vera is a succulent perennial plant that belongs to the liliaceae family and to a large family called xeroids. It is a magical plant with vast healing properties, but there is paucity in scientifi c literature on it effects on haematological parameters. The effect of persistent consumption of crude aqueous extract of Aloe vera on haematological indices of albino Wistar rats was investigated in this study. Methods: Twenty four rats were randomly assigned into three groups of eight rats each. Group 1 (control) received 0.26 mL of normal saline o.p. Group 2 received 0.26 mL of aloe vera extract for 2 weeks while group 3 received 0.26 mL of aloe vera extract for 4 weeks p.o. once daily. All animals receiveddrinking water and normal rat chow ad libitum. Results: Results revealed that the control group had a mean PCV of 37.50 ± 0.98%; Hb, 11.40 ± 0.39g/dL; RBC, 6.91 ±0.35 x10 6 cells/μL; WBC, 4.36 ± 0.54 x 10 3 cells/μL and platelet count, 670.13 ± 41.01 x10 3 cells/μL. These blood parameters were not signifi cantly different in group 2 animals compared with controls,but were signifi cantly higher in group 3 rats compared with controls. Differential WBC counts were as follows for control values: neutrophils, 23.25 ± 2.39%; lymphocytes, 72.88 ± 2.55%; monocytes, 0.13 ± 0.13%; eosinophils, 3.00 ± 0.71% and basophils, 0.13 ± 0.12%. Lymphocytes were signifi cantly (p<0.05) higher in group 3 compared with control group. Conclusion: Aloe vera extract contains phytochemicals that boost blood parameters and immunity on prolong consumption.
Effect of Aloe vera Leaf Gel and Pulp Extracts on the Liver in Type-II Diabetic Rat Models
Biological and …, 2004
The aim of this work was to investigate the effects of Aloe vera leaf pulp and gel extracts on the liver tissue of neonatal streptozotocin (n0STZ)-induced type-II diabetic rats. The diabetic rats were separated into four groups and each group was given the following samples by gavage, daily for 15 d: phosphate buffered saline (PBS; diabetic control), Aloe leaf pulp extract, Aloe leaf gel extract, glibenclamide. Liver tissues were examined histologically. The markers of oxidative stress: glutathione (GSH), non-enzymatic glycosylation (NEG) and lipid peroxidation (LPO), were determined in liver tissue. Biochemical parameters for liver function: serum alkaline phosphatase (ALP), and alanine transaminase (ALP) activities, were evaluated. All parameters were also determined in healthy (non diabetic) rats for comparison. In the diabetic control group, the degenerative changes in liver tissue were remarkable, while in the diabetic groups given Aloe pulp and gel extracts and glibenclamide, the damage to the liver tissue was decreased. The increase of GSH and the decrease of NEG and LPO in liver tissues with the treatment of Aloe gel extract, is consistent with the beneficial effect of Aloe. Serum ALP and ALT activities were also decreased in the groups given Aloe gel extract. It was concluded that Aloe gel extract has a protective effect comparable to glibenclamide against hepatotoxicity produced by diabetes if used in the treatment of type-II diabetes. compared to healthy control. b) pϽ0.01 compared to untreated diabetic control. c) pϽ0.05 compared to untreated diabetic control. d) pϽ0.001 compared to untreated diabetic control.