Directional communication during movement execution interferes with tremor in Parkinson's disease (original) (raw)
2018, Movement disorders : official journal of the Movement Disorder Society
Both the cerebello-thalamo-cortical circuit and the basal ganglia/cortical motor loop have been postulated to be generators of tremor in PD. The recent suggestion that the basal ganglia trigger tremor episodes and the cerebello-thalamo-cortical circuitry modulates tremor amplitude combines both competing hypotheses. However, the role of the STN in tremor generation and the impact of proprioceptive feedback on tremor suppression during voluntary movements have not been considered in this model yet. The objective of this study was to evaluate the role of the STN and proprioceptive feedback in PD tremor generation during movement execution. Local-field potentials of the STN as well as electromyographical and electroencephalographical rhythms were recorded in tremor-dominant and nontremor PD patients while performing voluntary movements of the contralateral hand during DBS surgery. Effective connectivity between these electrophysiological signals were analyzed and compared to electromyo...
Loading Preview
Sorry, preview is currently unavailable. You can download the paper by clicking the button above.