Effect of Inhaled Budesonide on Lung Function and Airway Inflammation (original) (raw)

1999, American Journal of Respiratory and Critical Care Medicine

In a double-blind, cross-over study, we examined the effect of inhaled budesonide (800 g twice daily via Turbohaler) on lung function and various markers of airway inflammation including airway responsiveness to methacholine (PC 20), exhaled nitric oxide (NO), eosinophils in induced sputum, bronchoalveolar lavage (BAL), and airway biopsies from 14 patients with mild asthma needing ␤ 2agonist therapy only. After inhaled steroids, there was a significant increase in FEV 1 and PC 20 , and reduction in exhaled NO. Eosinophils in induced sputum and airway biopsy sections were also significantly decreased, although BAL eosinophil counts remained unchanged. At baseline, significant correlations were observed between exhaled NO and PC 20 methacholine (r ϭ 0.64, p Ͻ 0.05), exhaled NO and peak expiratory flow rate (PEFR) variability (r ϭ 0.65, p Ͻ 0.05), sputum eosinophils and FEV 1 (r ϭ Ϫ 0.63, p ϭ 0.05), and sputum eosinophils and log PC 20 methacholine (r ϭ Ϫ 0.67, p Ͻ 0.05). After treatment with inhaled steroids, there was a significant correlation between eosinophils in biopsy sections, and BAL, with log PC 20 methacholine. It is likely that these parameters represent different aspects of the inflammatory process, which are all inhibited by inhaled steroids. Lim S, Jatakanon A, John M, Gilbey T, O'Connor BJ, Fan Chung K, Barnes PJ. Effect of inhaled budesonide on lung function and airway inflammation: assessment by various inflammatory markers in mild asthma .