Comparison of digital and visual methods for Ki-67 assessment in invasive breast carcinomas (original) (raw)
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Medicni perspektivi (Medical perspectives), 2021
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Problems in oncology, 2017
In 437 primary patients with breast cancer (BC) we compared diagnostic accuracy of mammography (MG) and mammoscintigraphy (MCG) with 99mTc-MIBI. All women, included in the study, had lesions suspicious for BC. In 108 suspicious lesions were less than 10 mm in diameter. On histology 33 (30,5%) patients had invasive BC, 20 (18,5%) - noninvasive BC, 6 (5,6%) - lobular carcinoma, 2 (1,9%) - mucinous BC, 8 (7,4%) - fibroadenoma and in remained 39 cases (36,1%) - localised fibrosis. In the group of women with lesions below 10 mm sensitivity, specificity and accuracy of MG in diagnosis of BC were 72%, 74%, 73%, for MCG - 62%, 51%, 57%. Combination of MG and MCG helped to increase sensitivity to 93,4%. In 53 women with dense breasts sensitivity, specificity and accuracy of MG were 40%, 71,4%, 64%; for mCg two times higher (82%) with specificity of 55% and 60% accuracy. Combination of MG and MCG allowed increasing the sensitivity of diagnosis of minimal BC 2 times more (up to 91%).
Journal of radiology and nuclear medicine, 2020
Objective. Atypical breast cysts are often quite a serious problem in noninvasive ultrasound differential diagnosis. To develop a system for automated analysis of grayscale ultrasound images, which on the principles of mathematical processing would make it possible to increase the specificity of diagnosis in this situation.Material and methods. The authors developed the CystChecker 1.0 software package. To test this system, they used a set of 217 ultrasound images: 107 cystic (including 53 atypical lesions that were hardly differentially diagnosed by standard methods) and 110 solid (both benign and malignant) breast masses. All the masses were verified by cytology and/or histology. Visual assessment was carried out analyzing grayscale ultrasound, color/power Doppler, and elastography images.Results. Using the system developed by the authors could correctly identify all (n = 107 (100%)) typical cysts, 107 (97.3%) of 110 solid masses, and 50 (94.3%) of 53 atypical cysts. On the contra...
JOURNAL of SIBERIAN MEDICAL SCIENCES, 2021
Cancer is a generic term that groups different types of malignant tumors. Each of them has a specifi c name according to the tissue that gave birth to it. It appears when cells multiply in an uncontrolled manner and take the place of healthy cells. Deaths from cancer are mainly due to damage caused by metastases. This is why it is important to diagnose the disease early, before it spreads in the body. After the diagnosis announcement, cancer management is put in place: it involves several treatments that are articulated throughout the course of care. Cancers have the particularity of reacting differently to treatments. Some types of cancer are best treated with surgery. Others respond better to drugs called chemotherapy. It often happens that several treatments are administered together to ensure the best possible results. Studies have so far focused largely on the tumor cell itself. The new challenge for researchers is now to understand how these cells interact with their immediate...
The use of imaging tests to obtain optimal margins in breast surgery
European Journal of Clinical and Experimental Medicine, 2019
Статья посвящена поиску ответа на вопрос: что означает когнитивный подход к жанру? Автор полагает, что цель когнитивного изучения жанра состоит в построении его ментальной модели, отражающей репрезентацию жанра в сознании писателя и читателя. Для решения этой задачи необходимо соотнести жанр с различными форматами знания-не только концептуально-простыми (концепт), но и концептуально-сложными (фрейм, сценарий, матрица и др.). Обзор работ зарубежных и отечественных исследователей позволяет определить доминанты когнитивного подхода к жанру: • рассмотрение жанровой формы как текучей, нестабильной структуры; • выявление жанровых прототипов; • внимание к жанровой динамике, гибридным образованиям. Перспективным направлением когнитивных исследований автор считает установление корреляций между традиционными понятиями жанрологии (память жанра, жанровый архетип, жанровый канон) и терминами когнитивной поэтики. The article is devoted to the search for the answer to the question what the cognitive approach to the genre means. The author believes that the goal of the cognitive studies of the genre is to build its mental model, reflecting its representation in the minds of the reader and writer. To solve this problem, it is necessary to correlate genres with different formats of knowledge, not only conceptually simple (such as concept), but also conceptually-complex ones (such as frame, script, matrix, etc.). The review of the works of foreign and Russian researchers makes it possible to determine the dominants of the cognitive approach to the genre. They are: • consideration of the genre form as a fluid, unstable structure; • identification of the genre prototypes; • attention to genre dynamics and hybrid formations. The author assumes that a perspective direction of cognitive studies is to establish the correlations between the traditional concepts of genre (genre memory, genre archetype, and genre canon) and the terms of cognitive poetics.
Three-Dimensional Planning of Brachytherapy for Locally Advanced Cervical Cancer by CT/Mri Images
Problems in oncology, 2018
We present our results of 3D CT/MRI brachytherapy (BT) planning in 115 patients with locally advanced cervical cancer T2b-3bN0-1M0. The aim of this study was to assess the differences in the visualization of tumor target volumes and risk organs during the 3D CT/MRI BT. The results of the study revealed that the use of MRI imaging for dosimetric planning of dose distribution for a given volume of a cervical tumor target was the best method of visualization of the soft tissue component of the tumor process in comparison with CT images, it allowed to differentially visualize the cervix and uterine body, directly the tumor volume. Mean D90 HR-CTV for MRI was 32.9 cm3 versus 45.9 cm3 for CT at the time of first BT, p = 0.0002, which is important for local control of the tumor process. The contouring of the organs of risk (bladder and rectum) through MRI images allows for more clearly visualizing the contours, which statistically significantly reduces the dose load for individual dosimetr...
Evaluation changes in indicators of oncological service in breast cancer in Kazakhstan
Journal "Medicine", 2020
According to estimates from the International Agency for Research on Cancer (IARC) by 2040 the global burden is expected to grow to 3 million new breast cancer cases and 1 million cancer deaths of this cause. Studying the indicators of the oncological service for breast cancer allows us to identify and evaluate the effectiveness of mammological screening in Kazakhstan. Aim. Evaluate some indicators of the oncological service at breast cancer in Kazakhstan in 2009 to 2018. Material and methods. The research material was data from the Ministry of Health of the Republic of Kazakhstan - annual form No.7 and No.35 regarding breast cancer (ICD 10 C50) for 2009-2018. - morbidity, mortality, early diagnosis, neglect, morphological verification. A retrospective study using descriptive and analytical methods of biomedical statistics was used as the main method. Results and discussion. For 2009-2018, 40,199 new cases of breast cancer were registered in the republic for the first time and 12,97...