Molecular analysis of the human fetal-to-adult globin switching (original) (raw)
A novel C-T transition within the distal CCAAT motif of the Gγ-globin gene in the Japanese HPFH: implication of factor binding in elevated fetal globin expression
Supan Fucharoen
Nucleic Acids Research, 1990
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Persistent γ-globin expression in adult transgenic mice is mediated by HPFH-2, HPFH-3, and HPFH-6 breakpoint sequences
Frank Grosveld
Blood, 2003
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Persistent ����-globin expression in adult transgenic mice by HPFH -2, HPFH -3 and HPFH -6 breakpoint sequences
Eleni Katsantoni
2003
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Expression of Human Globin Genes in Transgenic Mice Carrying the β‐Globin Gene Cluster with a Mutation Causing Gγβ+ Hereditary Persistence of Fetal Hemoglobina
Ajay Bhargava
Annals of the New York Academy of Sciences, 1990
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Expression of Human Globin Genes in Transgenic Mice Carrying the ?-Globin Gene Cluster with a Mutation Causing G ?? + Hereditary Persistence of Fetal Hemoglobin
Ajay Bhargava
Annals of the New York Academy of Sciences, 1990
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Persistent -globin expression in adult transgenic mice is mediated by HPFH-2, HPFH-3, and HPFH-6 breakpoint sequences
Eleni Katsantoni
2010
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Developmental regulation of human gamma- and beta-globin genes in the absence of the locus control region
Ajay Bhargava
Blood, 1994
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The relationship between the variations in Gγ and Aγ promotors and the Hereditary Persistence of Fetal Hemoglobin (HPFH)
Muhsin AYDIN
Cellular and molecular biology (Noisy-le-Grand, France), 2018
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A gene controlling fetal hemoglobin expression in adults is not linked to the non-alpha globin cluster
M. Bregni
The EMBO journal, 1983
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Molecular mechanisms of human hemoglobin switching: selective undermethylation and expression of globin genes in embryonic, fetal, and adult erythroblasts
Migliaccio Giovanni
Proceedings of the National Academy of Sciences, 1983
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An embryonic-specific repressor element located 3′ to the Aγ-globin gene influences transcription of the human β-globin locus in transgenic mice
Eleni Katsantoni
Experimental Hematology, 2004
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The role of the −50 region of the human γ-globin gene in switching
Dubravka Drabek
The EMBO Journal, 2001
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Human gamma-globin gene promoter element regulates human beta-globin gene developmental specificity
Tim Townes
Nucleic Acids Research, 2000
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Heterocellular hereditary persistence of fetal hemoglobin (HPFH). Molecular mechanisms of abnormal ?-gene expression in association with ? thalassemia and linkage relationship with the ?-globin gene cluster
Alessandra Carè
Human Genetics, 1984
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NRF2 mediates γ-globin gene regulation and fetal hemoglobin induction in human erythroid progenitors
Betty Pace
Haematologica, 2017
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Upstream promoter mutation associated with a modest elevation of fetal hemoglobin expression in human adults
Xiao-Jun Wen
Blood
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The Hellenic type of nondeletional hereditary persistence of fetal hemoglobin results from a novel mutation (g.-109G>T) in the HBG2 gene promoter
Marios Kalamaras
Annals of Hematology, 2009
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Globin Gene Switching
Thalia Papayannopoulou
Journal of Biological Chemistry, 1996
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Persistent fetal γ-globin expression in adult transgenic mice following deletion of two silencer elements located 3' to the human Aγ-globin gene
Eleni Katsantoni
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Promoters of the murine embryonic -like globin genes Ey and h1 do not compete for interaction with the -globin locus control region
Steven Fiering
Proceedings of the National Academy of Sciences, 2003
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Developmental and inducible patterns of human θ1-globin gene expression in embryonic/fetal and adult erythroid cells
Nicholas Moschonas
American Journal of Hematology, 1990
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Promoter sequences required for function of the human gamma globin gene in erythroid cells
N. Anagnou
The EMBO journal, 1986
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Different 3' End Points of Deletions Causing delta -thalassemia and Hereditary Persistence of Fetal Hemoglobin: Implications for the Control of gamma -globin Gene Expression in Man
Anh Tuan
Proceedings of The National Academy of Sciences, 1983
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The human beta-globin promoter; nuclear protein factors and erythroid specific induction of transcription
Michael Antoniou
The EMBO journal, 1988
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Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin
Laura Romero Gutiérrez
Nature Genetics, 2010
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Distal CCAAT box deletion in the A gamma globin gene of two black adolescents with elevated fetal A gamma globin
Xiao-Jun Wen
Nucleic Acids Research
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Increased protein binding to a −530 mutation of the human β-globin gene associated with decreased β-globin synthesis
Jacques Elion
American Journal of Hematology, 1991
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Activation of the δ-Globin Gene by the β-Globin Gene CACCC Motif
Susanna Porcu
Blood Cells, Molecules, and Diseases, 1999
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Distal CCAAT box deletion in the A γ globin gene of two black adolescents with elevated fetal A γ globin
Xiao-Jun Wen
Nucleic Acids Research, 1988
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Regulation of the Globin Genes
Paolo Moi
Pediatric Research, 2002
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Different 3' end points of deletions causing delta beta-thalassemia and hereditary persistence of fetal hemoglobin: implications for the control of gamma-globin gene expression in man
Anh Tran Tuan
Proceedings of the National Academy of Sciences, 1983
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Regulation of fetal versus embryonic gamma globin genes: appropriate developmental stage expression patterns in the presence of HS2 of the locus control region
Deborah Gumucio
Blood, 2002
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Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities
Arthur Nienhuis, Andrew Wilber
Blood, 2011
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