LDH as Predictive Parameter in Treatment‐Naïve Patients Affected by Chronic Lymphocytic Leukemia with Trisomy 12: CLL‐094 (original) (raw)

2018, Clinical Lymphoma, Myeloma & Leukemia

Context: Complex karyotype (CK) is associated with poor prognosis in patients with chronic lymphocytic leukemia (CLL). While mutations in TP53 have been associated with CK, overlap is not complete and the genetic landscape of patients with CLL and CK remains largely undescribed. Design: We performed targeted next generation sequencing with a SureSelect custom panel of 295 genes (Agilent Technologies, Santa Clara, CA) on bone marrow aspirate collected between March 2003 and October 2015 from 71 patients with CLL and CK and compared them to a control group of 90 patients without CK, age and sex-matched. Results: In univariable analyses (UVA), CK was associated with Rai III-IV disease (61% vs 36%, p1⁄40.002), beta-2 microglobulin (B2M) > 4 mg/L (67% vs 40%, p1⁄40.001), del(17p) by FISH (33% vs 9%, p<0.001), and presence of any gene mutation (79% vs 59%, p1⁄40.01). Among patients with CK, the most common mutations (>10% of patients) were TP53 (32%), SF3B1 (15.5%) and NOTCH1 (10...

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