Management of risk factors and pharmacological therapy in oral pemphigus vulgaris: A Case Report (original) (raw)
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Presentation and management of oral symptoms of pemphigus vulgaris: a case report
International Journal of Recent Scientific Research, 2017
Pemphigus Vulgaris is a rare autoimmune disease causing blistering of the skin due to the production of desmosomal antibodies. One of the most important clinical manifestations of pemphigus Vulgaris is the formation desquamated oral lesion on the gingiva. Such lesions are among the first to appear in patients who develops the disease and thus, knowledge of the presentation of the condition is of great importance as the dentist can be the first health care professional the patient suffering from the disease might seek. The clinician should not only assist with the early diagnosis but also provide symptomatic relief to the patient from oral discomfort as described in this case report.
Health Science Reports, 2022
Background and Aims Pemphigus vulgaris is an autoimmune vesiculobullous mucocutaneous disorder with life-threatening consequences. Early detection and adequate care are crucial for a good prognosis. This study aimed to determine the demographic data, clinical features, and the prognosis of patients with oral pemphigus vulgaris. Materials and Methods From 2001 to 2021, all diagnosed oral pemphigus vulgaris cases were extracted. Each patient's demographic and clinical data were gathered. Patients were called via phone to assess the prognosis, treatment type, and specialty of the physician who provided the diagnosis and therapy. Results The majority of the patients had only oral lesions with higher prevalence in female who also expressed severe pain than male. Only 14 of 29 patients responded phone calls. Except for one, all patients were in active disease. More than half of those respondents said pemphigus negatively affects social behavior and food intake. Correct diagnosis and treatment were decided by dermatology, oral medicine, and maxillofacial surgery specialists. Conclusion Oral pemphigus vulgaris was prevalent in females. Severe pain was common in females and older people. Even with effective therapy, the prognosis was poor. Medical and dental professionals had little knowledge of pemphigus vulgaris. Patients frequently report poor quality of life.
Oral Pemphigus Vulgaris: A Case Report and Review
Abstract: Pemphigus Vulgaris (PV) is chronic autoimmune mucocutaneous disease that initially manifests as intraoral lesions, which may later spread to skin. Dental professionals must be efficient to recognize the clinical features of pemphigus vulgaris to ensure early diagnosis and treatment, so that it determines the favorable prognosis and course of the disease. This paper reports a case of pemphigus vulgaris and review of literature. Key Words: Pemphigus Vulgaris, Nikolsky’s sign.
Oral pemphigus vulgaris: a case report with review of the literature
Journal of Oral Science, 2008
Pemphigus vulgaris is a chronic autoimmune mucocutaneous disease that initially manifests in the form of intraoral lesions, which spread to other mucous membranes and the skin. The etiology of pemphigus vulgaris is still unknown, although the disease has attracted considerable interest. The pemphigus group of diseases is characterized by the production of autoantibodies against intercellular substances and is thus classified as autoimmune diseases. Most patients are initially misdiagnosed and improperly treated for many months or even years. Dental professionals must be sufficiently familiar with the clinical manifestations of pemphigus vulgaris to ensure early diagnosis and treatment, since this in turn determines the prognosis and course of the disease. Here, we report a case of pemphigus vulgaris that was misdiagnosed in its earliest stage.
Severe manifestation of oral pemphigus
American Journal of Otolaryngology, 2011
This article describes a case of pemphigus vulgaris in a relatively young patient with exacerbated characteristics, widespread lesions, and rapid evolution. A 40-year-old woman sought treatment, complaining about severe oral pain and dysphagia. Intraoral inspection revealed ulcerated lesions on the lips, buccal mucosa, and floor of the mouth. The number of lesions quickly increased and resembled erythema multiforme. She also
Isolated oral pemphigus vulgaris: Case series of 15 patients
2022
Pemphigus is a chronic inflammatory autoimmune bullous disease that affects the oral mucosa and is sometimes difficult to diagnose when only mucosal involvement is present. We performed a retrospective descriptive study including 15 cases of isolated mucosal pemphigus (mPV). We noticed that this rare form is characterized by it slow healing, a female predominance with frequent relapses.
Characterization of oral pemphigus vulgaris in Thai patients
Journal of Oral Science, 2006
The oral mucosa is often the first site to be affected by the disease. It is thus important that the dentist is able to recognize oral manifestations of PV and refer appropriately. Although oral PV is a well-characterized condition, the disease characteristics of patients in Thailand have not been previously reported. Here, we describe patient and lesion characteristics of 18 cases of oral PV. For these 18 cases, the mean age was 38 years, and the male:female ratio was 1:2. The most commonly affected sites were the gingiva and buccal mucosa, and the duration of disease was approximately one year. Medications previously used included corticosteroids and interferon, and nine patients reported systemic disease. Histopathologic examination with/without direct immunofluorescence was the method of diagnosis in all cases. (J. Oral Sci. 48, [43][44][45][46] 2006)
Prevalence of oral lesions in pemphigus vulgaris: a retrospective study
International Journal of Research in Dermatology, 2019
Background: Pemphigus vulgaris is an autoimmune vesiculobullous disease characterized by vesicles and or bullae affecting skin and mucosa. Oral lesions are the first manifestation of the disease in majority of cases according to literature. This study is conducted to know the prevalence of oral lesions in pemphigus vulgaris patients at the time of presentation. Methods: This was a retrospective study. Departmental records were evaluated from January 2013 to January 2018. All the demographic data of pemphigus vulgaris patients at the time of first presentation, duration of disease, were assessed and tabulated. The clinical data of these patients during their subsequent visits to clinic were assessed for development of new oral lesions during course of disease. Results: Total number of patients were 55. The mean age was 42.5 years. 12 (21.8%) were males and 4 (78.1%) were females. Out of 55 patients 37 (67.27%) cases had oral involvement and 18 (32.72%) cases did not have oral lesions at the time of presentation. Out of 37 patients who had oral lesions, 34 (91.89%) patients had both oral and skin lesions and 3 (08.10%) patients had only oral lesions at the time of presentation. Out of the18 patients with no oral lesions, 3 (16.66%) patients developed oral lesions within 3 months. Total number of patients with oral lesions out of 55 were 40 (72.7%). Conclusions: Our study shows that oral lesions as initial manifestation of pemphigus vulgaris is 67.2%.
Pemphigus vulgaris: a case-based update
Journal (Canadian Dental Association), 2005
Pemphigus vulgaris (PV) is an autoimmune disease accounting for 80% of all cases of pemphigus. Before the advent of corticosteroid therapy, pemphigus was fatal, with a mortality rate of up to 75% in the first year. It is still a serious disorder, but the 5% to 10% mortality rate is now primarily due to the side effects of therapy. In 75% to 80% of cases, PV lesions first appear in the oral cavity. Dentists are therefore in a unique position to recognize the oral manifestations of the disease, allowing early diagnosis and initiation of treatment. The diagnosis is based on pathological examination and immunofluorescence testing. Systemic corticosteriods and steroid-sparing agents are the mainstays of treatment; topical corticosteroids may also be used to accelerate healing of persistent oral lesions. This article describes a 71-year-old woman with multiple chronic ulcers in the oral cavity, in whom PV was diagnosed 4 months after the symptoms first appeared. The article also reviews t...