Quinolone prophylaxis for bacterial infections in afebrile high risk neutropenic patients (original) (raw)

Quinolone prophylaxis for bacterial infections in afebrile high risk neutropenic patients 5

2000

These recommendations have been developed by an expert panel following an evidence- based search of the literature assessing the role of fluoroquinolones in the prevention of bacterial infection in patients with acute leukaemia or bone marrow transplantation and neutropenia. We present results from a questionnaire on the current practice among experts in Europe, show results of the literature search, review

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Prophylaxis with fluoroquinolones for bacterial infections in neutropenic patients: a meta-analysis. Clin Infect Dis 23:795–805

1996

We conducted a two-part meta-analysis to assess the effectiveness of fluoroquinolones for pre-venting bacterial infections in granulocytopenic patients who are receiving chemotherapy for malig-nancies. Overall, 19 randomized studies met selection criteria and were included in this meta-analysis of 2,112 patients. Thirteen studies that compared the fluoroquinolones alone with control regimens (co-trimoxazole, oral nonabsorbable antibiotics, or placebo) and six studies that compared the fluoroquinolones plus prophylaxis for bacteremia due to gram-positive bacteria with control regimens (fluoroquinolones or oral nonabsorbable antibiotics) were included in the two meta-analyses. The results of the first meta-analysis indicate that fluoroquinolones alone are effective in preventing gram-negative bacteremia (overall odds ratio [OR], 0.09; 95 % confidence interval [CI], 0.05-0.16; P <.001), but not gram-positive bacteremia (OR, 1.05; 95 % CI, 0.76-1.45; P =.7), fever-related morbidity (...

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Quinolone prophylaxis for bacterial infections in afebrile high risk neutropenic patients (original) (raw)

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