Nonlinear Regression on Manifolds for Shape Analysis using Intrinsic Bézier Splines (original) (raw)

A Nonlinear Hierarchical Model for Longitudinal Data on Manifolds

2022 IEEE 19th International Symposium on Biomedical Imaging (ISBI), 2022

Large longitudinal studies provide information that is particularly valuable in medical studies. A problem that must be solved in order to realize the full potential is the correlation between intra-subject measurements taken at different times. For data in Euclidean space this can be achieved with hierarchical models, i.e., models that account for intra-subject and between-subject variability at two different levels. However, data from medical studies often take values in nonlinear manifolds. For such data, as a first step, geodesic hierarchical models have been developed that generalize the linear ansatz by assuming that time-induced intra-subject variations occur along a generalized straight line in the manifold. However, this assumption often does not hold, for example in periodic motions or processes with saturation. As a more general alternative we propose a hierarchical model for manifold-valued data that incorporates trends along higherorder curves, namely Bézier splines in the manifold. To this end, we present a principled way of comparing shape trends in terms of a functional-based Riemannian metric. Remarkably, this metric allows efficient, yet simple computations by virtue of a variational time discretization that only requires solving regression problems. We validate our model using longitudinal data from the Osteoarthritis Initiative, including classification of disease progression.

Discrete Geodesic Regression in Shape Space

2013

A new approach for the effective computation of geodesic regression curves in shape spaces is presented. Here, one asks for a geodesic curve on the shape manifold that minimizes a sum of dissimilarity measures between given two-or three-dimensional input shapes and corresponding shapes along the regression curve. The proposed method is based on a variational time discretization of geodesics. Curves in shape space are represented as deformations of suitable reference shapes, which renders the computation of a discrete geodesic as a PDE constrained optimization for a family of deformations. The PDE constraint is deduced from the discretization of the covariant derivative of the velocity in the tangential direction along a geodesic. Finite elements are used for the spatial discretization, and a hierarchical minimization strategy together with a Lagrangian multiplier type gradient descent scheme is implemented. The method is applied to the analysis of root growth in botany and the morphological changes of brain structures due to aging. | day 54 | day 69 | day 83 | day 96 | day 109

Functional additive regression on shape and form manifolds of planar curves

2021

Defining shape and form as equivalence classes under translation, rotation and – for shapes – also scale, we extend generalized additive regression to models for the shape/form of planar curves or landmark configurations. The model respects the resulting quotient geometry of the response, employing the squared geodesic distance as loss function and a geodesic response function mapping the additive predictor to the shape/form space. For fitting the model, we propose a Riemannian L_2-Boosting algorithm well-suited for a potentially large number of possibly parameter-intensive model terms, which also yiels automated model selection. We provide novel intuitively interpretable visualizations for (even non-linear) covariate effects in the shape/form space via suitable tensor based factorizations. The usefulness of the proposed framework is illustrated in an analysis of 1) astragalus shapes of wild and domesticated sheep and 2) cell forms generated in a biophysical model, as well as 3) in ...

Intrinsic regression models for manifold-valued data

2009

Abstract. In medical imaging analysis and computer vision, there is a growing interest in analyzing various manifold-valued data including 3D rotations, planar shapes, oriented or directed directions, the Grassmann manifold, deformation field, symmetric positive definite (SPD) matrices and medial shape representations (m-rep) of subcortical structures.

A Hierarchical Geodesic Model for Longitudinal Analysis on Manifolds

Journal of Mathematical Imaging and Vision, 2022

In many applications, geodesic hierarchical models are adequate for the study of temporal observations. We employ such a model derived for manifold-valued data to Kendall’s shape space. In particular, instead of the Sasaki metric, we adapt a functional-based metric, which increases the computational efficiency and does not require the implementation of the curvature tensor. We propose the corresponding variational time discretization of geodesics and employ the approach for longitudinal analysis of 2D rat skulls shapes as well as 3D shapes derived from an imaging study on osteoarthritis. Particularly, we perform hypothesis test and estimate the mean trends.

Geodesic Shape Regression in the Framework of Currents

Lecture Notes in Computer Science, 2013

Shape regression is emerging as an important tool for the statistical analysis of time dependent shapes. In this paper, we develop a new generative model which describes shape change over time, by extending simple linear regression to the space of shapes represented as currents in the large deformation diffeomorphic metric mapping (LDDMM) framework. By analogy with linear regression, we estimate a baseline shape (intercept) and initial momenta (slope) which fully parameterize the geodesic shape evolution. This is in contrast to previous shape regression methods which assume the baseline shape is fixed. We further leverage a control point formulation, which provides a discrete and low dimensional parameterization of large diffeomorphic transformations. This flexible system decouples the parameterization of deformations from the specific shape representation, allowing the user to define the dimensionality of the deformation parameters. We present an optimization scheme that estimates the baseline shape, location of the control points, and initial momenta simultaneously via a single gradient descent algorithm. Finally, we demonstrate our proposed method on synthetic data as well as real anatomical shape complexes.

Shape splines and stochastic shape evolutions: A second order point of view

Quarterly of Applied Mathematics, 2012

This article presents a new mathematical framework to perform statistical analysis on time-indexed sequences of 2D or 3D shapes. At the core of this statistical analysis is the task of time interpolation of such data. Current models in use can be compared to linear interpolation for one-dimensional data. We develop a spline interpolation method which is directly related to cubic splines on a Riemannian manifold. Our strategy consists of introducing a control variable on the Hamiltonian equations of the geodesics. Motivated by statistical modeling of spatiotemporal data, we also design a stochastic model to deal with random shape evolutions. This model is closely related to the spline model since the control variable previously introduced is set as a random force perturbing the evolution. Although we focus on the finite-dimensional case of landmarks, our models can be extended to infinite-dimensional shape spaces, and they provide a first step for a nonparametric growth model for shapes taking advantage of the widely developed framework of large deformations by diffeomorphisms. Contents

Manifold Valued Statistics, Exact Principal Geodesic Analysis and the Effect of Linear Approximations

Lecture Notes in Computer Science, 2010

Manifolds are widely used to model non-linearity arising in a range of computer vision applications. This paper treats statistics on manifolds and the loss of accuracy occurring when linearizing the manifold prior to performing statistical operations. Using recent advances in manifold computations, we present a comparison between the non-linear analog of Principal Component Analysis, Principal Geodesic Analysis, in its linearized form and its exact counterpart that uses true intrinsic distances. We give examples of datasets for which the linearized version provides good approximations and for which it does not. Indicators for the differences between the two versions are then developed and applied to two examples of manifold valued data: outlines of vertebrae from a study of vertebral fractures and spacial coordinates of human skeleton end-effectors acquired using a stereo camera and tracking software.

Higher-order smoothing splines versus least squares problems on Riemannian manifolds

Journal of Dynamical and Control Systems, 2010

In this paper, we present a generalization of the classical least squares problem on Euclidean spaces, introduced by Lagrange, to more general Riemannian manifolds. Using the variational definition of Riemannian polynomials, we formulate a high order variational problem on a manifold equipped with a Riemannian metric, which depends on a smoothing parameter and gives rise to what we call smoothing geometric splines. These are curves with a certain degree of smoothness that best fit a given set of points at given instants of time and reduce to Riemannian polynomials when restricted to each subinterval.

Principal Geodesic Analysis for the Study of Nonlinear Statistics of Shape

IEEE Transactions on Medical Imaging, 2004

A primary goal of statistical shape analysis is to describe the variability of a population of geometric objects. A standard technique for computing such descriptions is principal component analysis. However, principal component analysis is limited in that it only works for data lying in a Euclidean vector space. While this is certainly sufficient for geometric models that are parameterized by a set of landmarks or a dense collection of boundary points, it does not handle more complex representations of shape. We have been developing representations of geometry based on the medial axis description or m-rep. While the medial representation provides a rich language for variability in terms of bending, twisting, and widening, the medial parameters are not elements of a Euclidean vector space. They are in fact elements of a nonlinear Riemannian symmetric space. In this paper, we develop the method of principal geodesic analysis, a generalization of principal component analysis to the manifold setting. We demonstrate its use in describing the variability of medially-defined anatomical objects. Results of applying this framework on a population of hippocampi in a schizophrenia study are presented.