A Review on Phytochemistry and Traditional Therapeutic Benefits of Syzygium Malaccense (L.) (original) (raw)

Physico-Chemical Characterization, Bioactive Compounds and Antioxidant Activity of Malay Apple [Syzygium malaccense (L.) Merr. & L.M. Perry]

PLOS ONE, 2016

The purpose of this study was to evaluate the physico-chemical characteristics, bioactive compounds and antioxidant activity of Malay apple fruit (Syzygium malaccense) grown in Brazil with regard to the geographical origin and its peel fractions and edible portion analyzed independently. Fruit diameter, weight, yield, and centesimal composition, ascorbic acid, reductive sugars, total soluble solids, pH and fiber content were determined. Total phenolics (1293 mg gallic acid equivalent/100 g) and total anthocyanins (1045 mg/100 g) contents were higher in the peel, with the major anthocyanin identified using HPLC-DAD-MS/MS as cyanidin 3-glucoside. Higher values for DPPH antiradical scavenging activity (47.52 μMol trolox equivalent antioxidant capacity/g) and Ferric Reducing Antioxidant Potential (FRAP, 0.19 mM ferreous sulfate/g) were also observed in the peel fraction. All extracts tested showed the ability to inhibit oxidation in the β-carotene/linoleic acid system. This study highlights the potential of Malay apple fruit as a good source of antioxidant compounds with potential benefits to human health.

Phytochemical Profile, Biological Properties, and Food Applications of the Medicinal Plant Syzygium cumini

Foods, 2022

Syzygium cumini, locally known as Jamun in Asia, is a fruit-bearing crop belonging to the Myrtaceae family. This study aims to summarize the most recent literature related to botany, traditional applications, phytochemical ingredients, pharmacological activities, nutrition, and potential food applications of S. cumini. Traditionally, S. cumini has been utilized to combat diabetes and dysentery, and it is given to females with a history of abortions. Anatomical parts of S. cumini exhibit therapeutic potentials including antioxidant, anti-inflammatory, analgesic, antipyretic, antimalarial, anticancer, and antidiabetic activities attributed to the presence of various primary and secondary metabolites such as carbohydrates, proteins, amino acids, alkaloids, flavonoids (i.e., quercetin, myricetin, kaempferol), phenolic acids (gallic acid, caffeic acid, ellagic acid) and anthocyanins (delphinidin-3,5-O-diglucoside, petunidin-3,5-O-diglucoside, malvidin-3,5-O-diglucoside). Different fruit ...

Antioxidant Compounds from The Stem Bark of Syzygium samarangense L

Molekul

Ogan ethnic community in South Sumatera has been used a decoction of the stem bark of Syzygium samarangense L (locally named “jambu air” in Indonesia) for hypertension medicine. Hypertension is a degenerative disease caused by free radical activity in the body. This study aims to scientifically prove the use of a decoction of the stem bark of S. samarangense so that its use by the Ogan ethnic community can be justified. The research began with fractionation of the stem bark by gradient solvents, and each fraction was tested for antioxidant activity. Isolation of antioxidant compounds from active fractions was carried out by chromatographic techniques. Antioxidant tests on fractions and pure compounds were carried out by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. Based on spectroscopic data analysis and by comparing with literature, the pure compounds were identified as quercetin and gallic acid. Both of these compounds have strong antioxidant activity with IC50 quercetin 11.16...

Pharmacological potentials of Syzygium cumini : a review

Journal of the Science of Food and Agriculture, 2013

In the last few years there has been an exponential growth in the field of herbal medicine and these drugs are gaining popularity both in developing and developed countries because of their natural origin and lesser side effects. Syzygium cumini (syn. Eugenia jambolana, Syzygium jambolana, Eugenia cumini, Syzygium jambos) commonly known as "Jamun" in India, is an evergreen tree distributed in the Indian sub-continent, southeast Asian countries and eastern Africa. It is mainly utilised as a fruit producer and for its timber. Medicinally, the fruit is stated to have anti-diabetic, anti-hyperlipidemic, anti-oxidant, anti-ulcer, hepatoprotective, anti-allergic, anti-arthritic, anti-microbial, anti-inflammatory, anti-fertility, anti-pyretic, anti-plaque, radioprotective, neuropsychopharmacological, nephroprotective and anti-diarrhoeal activities. Among these beneficial physiological effects, the anti-diabetic property of S. cumini has the most promising nutraceutical value. These health beneficial effects of S.cumini are mainly attributed to the various phytoconstituents such as tannins, alkaloids, steroids, flavonoids, terpenoids, fatty acids, phenols, minerals, carbohydrates and vitamins present in the fruit. This review presents an overview of experimental evidences for the pharmacological potential of S. cumini.

Total phenolic content, flavonoid content, and antioxidant capacity of Syzygium. cumini (L.) Skeels leaves grown in Wonosobo, Java, Indonesia and comparison against current findings of Syzygium cumini leaves andSyzygium polyanthum (Wight) Walp leaves

2018

Eight selected wild vegetables from Nepal (Alternanthera sessilis, Basella alba, Cassia tora, Digera muricata, Ipomoea aquatica, Leucas cephalotes, Portulaca oleracea and Solanum nigrum) were investigated for their antioxidative potential using 2,2-dyphenyl-1-picrylhydrazyl (DPPH) scavenging, hydrogen peroxide (H 2 O 2), ferric reducing antioxidant power (FRAP), and ferric thiocyanate (FTC) methods. Among the selected plant extracts C. tora displayed the highest DPPH radical scavenging activity with an IC 50 value 9.898 µg/mL, whereas A. sessilis had the maximum H 2 O 2 scavenging activity with an IC 50 value 16.25 µg/mL-very close to that of ascorbic acid (16.26 µg/mL). C. tora showed the highest absorbance in the FRAP assay and the lowest lipid peroxidation in the FTC assay. A methanol extract of A. sessilis resulted in the greatest phenolic content (292.65 ± 0.42 mg gallic acid equivalent (GAE)/g) measured by the Folin-Ciocalteu reagent method, while the smallest content was recorded for B. alba (72.66 ± 0.46 GAE/g). The greatest flavonoid content was observed with extracts of P. oleracea (39.38 ± 0.57 mg quercetin equivalents (QE)/g) as measured by an aluminium chloride colorimetric method, while the least was recorded for I. aquatica (6.61 ± 0.42 QE/g). There was a strong correlation between antioxidant activity with total phenolic (DPPH, R 2 = 0.75; H 2 O 2 , R 2 = 0.71) and total flavonoid content (DPPH, R 2 = 0.84; H 2 O 2 , R 2 = 0.66). This study demonstrates that these wild edible leafy plants could be a potential source of natural antioxidants.

Exploring the Therapeutic Potential of Syzygium cumini

INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES, 2024

A fruit-bearing tree with botanical and medical significance, Syzygium cumini is another name for Jamun. This abstract summarizes its traditional usage, phytochemistry, pharmacological actions, and botanical description. A native of the Indian subcontinent, the Syzygium cumini is an evergreen tree of modest size. Ovoid, dark purple to black fruits are tasty and astringent when ripe; the plant has glossy, dark-green foliage and pinkish-white blossoms. 'Phytochemical studies have shown that the plant contains essential oils, tannins, polyphenols, and flavonoids, among other beneficial components.' Its antioxidant qualities are due in part to the anthocyanins and ellagic acid it contains. The pharmacological activity of Syzygium cumini have been studied and found to include anti-diabetic, antioxidant, anti-inflammatory, and antimicrobial actions. Because of their capacity to lower blood glucose levels, the fruit and other plant components have been investigated for their possible use in diabetes management. It is useful for preventing diseases caused by oxidative stress because of its antioxidant characteristics.For ages, Syzygium cumini has been a part of traditional medicine. It is suggested for management of diabetes and its complications in Ayurveda and traditional Indian medicine. Traditional medicine has long made use of this plant's bark, leaves, and fruit to alleviate a wide range of symptoms, from skin problems to diarrhea and dysentery. People eat this fruit because it has health advantages and nutrients.

Phytochemical Screening and Antioxidant Potential of Syzygium cumini Leaves

Agricultural Science Digest – A Research Journal, 2023

Background: As a source of alternative medicines, plant derived drugs are of great potential and can be used to cure various health related ailments. One of the most common medicinal plant, Syzygium cumini commonly known as Jamun is well known for its various pharmaceutical properties. In the traditional medicine, the entire plant has been widely used in the treatment of various diseases. For the treatment of diabetes, the preparation of tea from the leaves of Syzygium cumini is known for its hypoglycaemic effect. Leaves are also used in the treatement of various skin diseases. Methods: Keeping in view the above concerns, the investigation of this plant aims to assess the phytochemical and antioxidant content of the ethyl acetate extract of locally available Syzygium cumini leaves samples acquired from the campus of Chaudhary Charan Singh Haryana Agricultural University, Hisar. The proposed study was conducted in Department of Chemistry, CCS HAU, Hisar during 2019-2021. Samples were collected and moisture content was estimated. Various chemicals and phytonutrients like alkaloids, tannins, minerals, crude protein, crude fibre, flavonoids and total phenolics were investigated in shade dried samples. Result: The total phenolic and flavanoid content were 11.48 mg GAE/g and 5.17 mg CE/g, respectively. The antioxidant activity of Syzygium cumini leaves extract was investigated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay and total antioxidant capacity using phospho-molybdenum assay. The result showed that ethyl acetae extract of Jamun leaves had potential antioxidant activity which justifies their medicinal applications for the treatment of various ailments.

Phenolic contents-based assessment of therapeutic potential of Syzygium cumini leaves extract

PLOS ONE, 2019

Syzygium cumini (S. cumini) is an evergreen tropical plant that is well recognized for its therapeutic potential of common diseases. In this study, the therapeutic potential and biomedical application of S. cumini are assessed in vitro and in vivo to find its effectiveness for different complications. The methanolic crude extract of S. cumini leaves were screened for total phenolic and flavonoid content. In vitro, the DPPH scavenging assay, XTT assay, prothrombin and activated partial thromboplastin time were used to assess antioxidant, cytoprotective and thrombolytic activity of the S. cumini extract, respectively. The antiinflammatory potential and the analgesic activity of the S. cumini extract were analyzed in rabbits by the Carrageenan induced paw edema method and the writhing method, respectively. Phytochemical analysis showed the presence of considerable amounts of total phenolic (369.75 ± 17.9 mg GAE/g) and flavonoid (75.8 ± 5.3 mgRE/g) content in the S. cumini extract. The DPPH assay demonstrated a higher antioxidant potential (IC-50 value of 133 μg/ml), which was comparable to the IC-50 of ascorbic acid (122.4 μg/ml). Moreover, the S. cumini extract showed a dose dependent cytoprotective effect against H 2 O 2 treated bone marrow mesenchymal stem cells (BM-MSCs). S. cumini also possesses significant anticoagulant activity with a prothrombin time of 28.3 ± 1.8 seconds vs 15.8 ± 0.2 seconds of control, p<0.05. The leaf extract also demonstrated an analgesic effect in rabbits as indicated by the decrease in writhing (12.2 ± 1.7 control vs. 3.7 ± 0.6 treated) and anti-inflammatory activity in rabbits paw with a protection against inflammation of 64.1 ± 2.4%. Our findings suggest that the methanolic extract of S. cumini leaves has antioxidant, cytoprotective, anticoagulant, analgesic and anti-inflammatory properties, and therefore, can be applied for treating cardiovascular diseases and cancers.

Syzygium cumini (L.) Skeels: A multipurpose tree, its phytotherapic and pharmacological uses

Syzygium cumini (L.) Skeels (syn. Eugenia Jambolana) is a multipurpose large, evergreen native tree species belongs to the Myrtle (Myrtaceae) family. The present review has been primed to describe the existing data on the information on botany, phytotherapic and pharmacological uses of S. cumini. The plant has been viewed as an antidiabetic plant and is an integral part in the various alternative systems of medicine. Scientific studies have shown that the various extracts of Jamun possess a range of pharmacological properties such as antibacterial, antifungal, antiviral, anti-inflammatory, anti-ulcerogenic, cardioprotective, anti-allergic, anticancer, radioprotective, antioxidant, hepatoprotective, anti-diarrheal, hypoglycemic and antidiabetic effects. The vast number of literatures found revealed that the extracts of different parts of jambolan showed significant pharmacological actions. It is suggested that there is a need for further investigation to isolate active principles which confer the pharmacological action. This in turn helpful in production of safer drugs in the treatment of various ailments including diabetes.