Clinical significance of hyper-IgA in a paediatric laboratory series (original) (raw)

This study investigates the clinical significance of hyper-IgA levels in children, analyzing serum IgA measurements collected from a pediatric hospital over a four-year period. Out of 6,364 subjects, 91 children exhibited hyper-IgA, predominantly associated with severe immune defects, chronic rheumatic diseases, or inflammatory bowel disease, contrasting a very low prevalence of these conditions in a control group with normal IgA levels. The findings suggest that hyper-IgA could be an important diagnostic marker for serious underlying health issues in pediatric patients.