Comparison of neonatal electroencephalogram changes in three month old neonates with seizure in Bu-Ali Hospital of Ardabil city, Iran 2017 (original) (raw)

2020, International Journal of Contemporary Pediatrics

Seizures are one of the most common problems in neonates and sometimes it's the first symptom of neurological dysfunction in neonates with a prevalence of 1.4-8.6 per 1000 live births. 1-5 In most cases, neonatal seizures improve by age, but in 25% to 35% of cases, neurological developmental defects persist. 6 Neonatal seizures develop due to various causes such as hypoxic-ischemic encephalopathy, central nervous system infection, intracranial hemorrhage, brain structural abnormalities, and metabolic disorders that among them, hypoxic-ischemic encephalopathy is the most common cause and accounts for 50-75% of all causes. 1 In most cases, the diagnosis of neonatal seizures is based on history, direct observation, and para-clinical findings, and in the absence of timely diagnosis and treatment, it can be associated with increased mortality and persistent ABSTRACT Background: The prevalence of neonatal seizure in term neonates is 3 per 1000 births, but in preterm newborns is 50 per 1000 births. Babies who have seizures are at high risk of death or neurological disabilities. Seizure is often the first sign of neonatal dysfunction and may be effective in long-term prognosis. EEG is the only available method for the diagnosis of seizures in neonates. The aim of this study was to Comparison of EEG changes in neonatal period and three months of age in patients with history of neonatal seizure. Therefore, authors compared EEG changes in the first EEG infant seizure with 3 months of age in newborns who referred to the Aristotelian hospital in Bouali Hospital. Methods: The present study is a cross-sectional descriptive analytical method. In this study, neonates referred to Ardabil Booali Hospital, EEG, were screened for seizure and EEG was monitored 3 months later and the results were evaluated. Finally, all the data were entered into the SPSS-24 statistical analysis program and authors analyzed the data according to the type of variables by statistical tests. Results: In this study, 50 neonates with seizure were enrolled in this study, 70% of which had an average age of 14.92 days. 80% of infants were born at the time of term. The average birth weight was 3.208 kg. 6.2% of infants had abnormal CT scan findings, with an IVH infant and one baby showing brain edema. In this study, only 14% of neonates with abnormal brain strain were observed in the neonatal period and near the seizure. However, after 3 months, 40% of infants experienced abnormal brain stroke findings. Among the changes in EEG with age (p=0.173), gestational age (p=0.616), gender (p=0.176), seizure (p=0.145), neonatal hypoglycemia (p=0.594), hypocalcaemia (p=0.607) no statistic was found. Conclusions: The results of this study showed that a small percentage of neonates had abnormal EEG in the neonate, but after 3 months of seizure, the larger percentage of them found abnormal EEG.