Additional file 5: Figure S4. of Dual role of CD44 isoforms in ampullary adenocarcinoma: CD44s predicts poor prognosis in early cancer and CD44ν is an indicator for recurrence in advanced cancer (original) (raw)

2016

Abstract

The most significant 122 genes associated with pancreatic invasion were analyzed by IPA6.0. Gene network was represented as nodes and lines between two nodes. Node shapes symbolized the functional class of the gene product: inverted bell, cytokine and growth factor; hook, enzyme; trefoil, kinase; dumbbells, transcription regulator; upward scoop, transmembrane receptor; circle, complex or other. The bar graph right to the particular molecules depicted as the relative fold change of the particular gene and the bar from left to right was represented as patient 1 to 5. The log ratio of fold change in gene expression was represented as number under the particular molecules. The intensity of node colors indicated the degree of upregulation (red) or downregulation (green) in ampullary cancer than normal duodenum. Continuous and dashed lines indicated direct and indirect interactions between molecules, respectively. Bold nodes with blue rims represented genes associated with EMT or colorect...

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