Retroperitoneal granulosa cell tumor (original) (raw)
Related papers
Pelvic ultrasound scanning in asymptomatic adult-type granulosa cell tumor: A case report and review
2021
Background: Ovarian cancer is common amongst women worldwide. In Indonesia, it is the fourth most common female cancer with a 5-year survival rate of 45%, but can reach up to 92% if treated early. Granulosa cell tumors (GCT) arise from the sex-cord and are considered malignant. This study presents a rare case of asymptomatic adult-type granulosa cell tumor in an elderly lady diagnosed during routine pelvic ultrasound scanning. Case Illustration: A 65-year-old lady, P2A0, was referred due to left ovarian mass three years before admission. A left adnexal mass was palpated with no sign of internal genital adhesion. Transvaginal ultrasound showed atrophy of uterus and thin endometrial layer. One solid adnexal mass with a cystic part was found on the left adnexal with papillary projection and low resistance index. Histopathological examination revealed adult type-granulosa cell tumor and classical Call-Exner body with grooved nuclei (coffee bean nuclei). Diagnosis of GCT was made by hist...
Open Journal of Obstetrics and Gynecology, 2012
Introduction: Extraovarian granulosa cell tumor (GCT) is a very uncommon tumor, assumed to arise from the ectopic gonadal tissue along the embryonal route of the genital ridge. Case Report: We report the case of a 25 year-old woman who was presented at the emergency unit with a severe abdominal pain focused on the left iliac fossa. The patient had delivered normally 2 months before. An ovarian mass of 79 × 67 × 89 mm was shown in vaginal ultrasound as well as at the abdominal scan. Exploratory laparoscopy was performed and a torsion of the fallopian tube and an hematosalpinges was visualized. Re-vascularisation was not achieved and a left salpingectomy took place. The immuno-histopathology report revealed an extraovarian GCT deriving from the fimbriae of the tube. Follow-up surgery was discussed. The case is presented for its rarity.
A Case of Sex Cord-Stromal Tumor Originating in the Retroperitoneal Space
Cureus
A 54-year-old man was seen in the clinic with the chief complaint of epigastric pain radiating to the left groin region and a predominant postprandial abdominal discomfort. Upon examination, a painless round mass with reduced mobility was felt in the left flank during deep palpation of the abdomen. His past medical history was irrelevant. Ultrasound and IV contrast-enhanced CT scan confirmed the presence of a large tumor and an exploratory laparotomy for removal of the tumor was performed. The microscopic examination of the specimen confirmed the primary diagnosis of retroperitoneal tumor (RPT) and identified it as an extragonadal germ cell tumor with a vestigial origin, which is a rare type affecting the kidney and adrenal gland. Primitive RPTs are histologically classified as mesenchymal and neuroectodermal or vestigial. These histological types are rarely found in surgical practice and are challenging to diagnose and treat due to the peculiarities of the site of origin where they develop. RPTs are extremely rare and approximately 80% are malignant and detected lately during the disease's course, commonly discovered in advanced stages of local or systemic evolution. Currently, surgical intervention remains the only effective method of treating these tumors.
Urology, 2001
A primary extragonadal germ cell tumor of the retroperitoneum was diagnosed in a 47-year-old man without elevated serum alpha-fetoprotein, human chorionic gonadotropin, or lactate dehydrogenase levels. The diagnosis was made by histologic analysis after resection. The patient responded well to a combination of cisplatin, etoposide, and ifosfamide, achieving a partial response with four cycles. Residual tumor resection revealed necrotic tissue only. The patient was alive and disease free 24 months after diagnosis. The diagnostic difficulties of this particular situation are discussed. UROLOGY 58: 281xv-281xviii, 2001.
Adult Type Granulosa Cell Tumour in a Peri-Menopausal Woman: A Rare Ovarian Malignancy
2020
Granulosa cell tumors of the ovary are exceedingly rare neoplasms that originate from sex-cord stromal cells. The long natural history of granulosa cell tumors and their tendency to recur years after the initial diagnosis are the most prominent of their characteristics. The secretion of estradiol is the reason for signs at presentation such as vaginal bleeding and precocious puberty. Abdominal pain and hemoperitoneum, which occasionally can occur, are attributable to tumor rupture. The most common finding in pelvic examination is a tumor mass, which is subsequently confirmed with imaging techniques. Surgery is the mainstay of initial management for histological diagnosis, appropriate staging, and debulking. Chemotherapy is the treatment of choice for patients with advanced, recurrent, or metastatic disease, and BEP is the preferred regimen. Although the overall rate of response to treatment is high, the impact of treatment on disease-free or overall survival is unknown. Prolonged su...
Granulosa Cell Tumors of the Ovary: A Retrospective Tertiary Center Experience
Journal of clinical obstetrics & gynecology, 2021
Granulosa cell tumor (GCT) is a rare ovarian malignancy originating from sex cord-stromal cells. Sex cord stromal tumors account for 5-8% of all ovarian malignancies. 1 GCTs, which constitute approximately 70% of sex cord stromal ovarian tumors, are seen in 0.4-1.7 per 100,000 women. They are divided into 2 subgroups as juvenile (5%) and adult (95%) tumors based on their clinical presentation and histologic characteristics. The only clinically proven prognostic factor regarding recurrence is stage. However, patient age, tumor size, presence of intraperitoneal disease and the scope of the operation also play a role in prognosis. 2 Histological prognostic factors include nuclear atypia and mitosis. 3 Average recurrence is 5 years after surgery for the primary tumor. However, cases recurring even 20-30 years after the initial diagnosis have been reported in the literature. 4 Only 2% of GCT cases are bilateral, and most cases are diagnosed at Stage 1. Synchronous GCT has also been reported very rarely. They are usually lowgrade tumors with good prognosis. The most common presentation includes abdominal pain and distention. 5 Also they can secrete estrogen. Endometrial thickness should be evaluated with transvaginal ultrasound
Adult granulosa cell tumor associated with endometrial carcinoma: a case report
Journal of Medical Case …
Introduction: If strict criteria for the diagnosis of carcinoma are used and all patients with granulosa cell tumors are considered, the best estimate of the incidence of associated endometrial carcinomas is under 5%. In patients with granulosa cell tumors, estrogen-dependent endometrial cancers are rarely found, and most of these endometrial cancers are well-differentiated endometrioid adenocarcinomas that carry a good prognosis when detected early. Case presentation: We report the case of a 65-year-old post-menopausal Nigerian woman of the Igbo tribe with an adult granulosa cell tumor that was initially treated as endometrial carcinoma. She underwent a total abdominal hysterectomy and a bilateral salpingo-oophorectomy after histopathologic confirmation of a well-differentiated granulosa cell tumor of the ovary and a nuclear grade 1 adenocarcinoma of the endometrium (International Federation of Obstetricians and Gynecologists stage 1B). She had a good post-operative recovery and was discharged 10 days after treatment. Conclusion: The association between adult granulosa cell tumors of the ovary and endometrial carcinomas is rare. A high index of suspicion as well as good imaging and histopathologic analyses are important in making this diagnosis.