Rare cervical malignancy: a case of small cell neuroendocrine tumour of the cervix (original) (raw)
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Small cell neuroendocrine cervical carcinoma with 1-year follow-up: case report and review
Anticancer research
Small cell neuroendocrine cervical carcinoma (SCNCC) is a rare tumor that comprises 1-3% of cervical tumors. SCNCC exhibits clinical and biological characteristics of both cervical neoplasm (such as local aggressiveness and involvement of papillomavirus) and neuroendocrine small cell cancer of any site (such as early dissemination of the disease and loss of heterozygozity at different loci) making it an original nosologic entity. There is no unanimous opinion regarding the optimal management strategy. A 48-year-old Caucasian woman, para 3, referred postmenopausal bleeding of 2 months' duration. Preoperative investigation diagnosed an infiltrating squamous carcinoma of the cervix. A radical hysterectomy with bilateral salpingo-oophorectomy, pelvic and para-aortic lymphadenectomy were performed. Final diagnosis was SCNCC (FIGO stage III B) and therefore adjuvant radiochemotherapy was given. At 1-year follow-up the patient was free of disease. Despite the retrospective studies and ...
Small Cell Carcinoma of the Uterine Cervix with Large Cell Neuroendocrine Carcinoma Component
Gynecologic Oncology, 1998
A case of cervical small cell carcinoma (SCC) with large cell neuroendocrine carcinoma (LCNC) differentiation is presented. A 35-year-old Taiwanese woman was diagnosed as having stage IIB bulky SCC confirmed by cervical biopsy and underwent induction combination chemoradiotherapy followed by hysterectomy. The pathology of the cervical tumor after the initial treatment showed the residual tumor to be LCNC instead of SCC. Histochemistry, immunohistochemistry, and electron microscopy demonstrated presence of neuroendocrine differentiation on both the biopsy and the surgical specimens. Following surgical resection a course of adjuvant chemotherapy and a local radiation boost were added. Despite complete local control, she developed brain metastasis 8 months later and vertebral spread soon thereafter. The pathology of the brain tumor showed pure SCC. The patient died 19 months after diagnosis and 13 months after completion of treatment. This case suggests that SCC with LCNC component has a similar clinical course as a pure SCC.
Journal of Pathology of Nepal, 2020
Squamous cell carcinoma and adenocarcinoma are the most common histological types of cervical cancer. The co-existence of two histological types is rare. Here we report a case of a 65-year-old woman with a complaint of postmenopausal bleeding and a history of foul-smelling discharge per vagina for 8 months. On examination cervix flared up with growth, bled on touch, parametrium was involved and adherent anteriorly with bladder & posteriorly with the rectum. Cervical biopsy revealed small cell carcinoma coexisting with Adenocarcinoma. Later it was confirmed by immunohistochemistry.
Neuroendocrine tumors of the uterine cervix
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2000
Four main clinicopathologic features of neuroendocrine tumors (NETs) of the cervix may be stressed: primary diagnosis at an advanced stage, early nodal metastasis even for low disease, early failure of appropriate local treatment (surgery and / or radiation therapy) and aggressive clinical treatment. Five patients with NET of the uterine cervix (small cell carcinoma type) are reported (one stage I, two stages II, one stage III and one stage IV). One patient was treated by surgery combined with radiation therapy, one by surgery combined with chemotherapy and one by surgery with radiation therapy and chemotherapy. Two patients received radiation therapy alone. Three early stage patients are alive with no evidence of disease 8, 26 and 41 months after diagnosis. The two patients with advanced stage died of disease, 3 and 12 months respectively, after diagnosis. Combination chemotherapy (cisplatin and etoposide) is warranted in disseminated NETs. Neoadjuvant or adjuvant chemotherapy should be combined with radiation therapy and surgery even in early stages.
Cervical Neuroendocrine Carcinoma: A Rare Case Report
Cureus
Neuroendocrine carcinoma is a rare tumor in the uterine cervix with a dismal prognosis. Clinically, it is difficult to differentiate from other cervical malignancies. Clinical presentation varies from vaginal bleeding, discharge per vaginum and cervical mass. For better clinical outcomes, it is vital to diagnose promptly and accurately. We report a 35-year-old female presented with whitish discharge per vaginum and lower abdominal pain for six months. Per speculum reveals an irregular, firm mass measuring 4x3 cm involving both the cervical lips, which turned out to a small cell neuroendocrine carcinoma.