Typical Clinical and Neuroimaging Features in Methanol Intoxication (original) (raw)
Related papers
Imaging findings after methanol intoxication (cohort of 46 patients)
Neuro endocrinology letters, 2015
OBJECTIVES Our goal is to demonstrate the variability of imaging findings, primarily in the MRI, in 46 patients who survived acute methanol poisoning. This cohort of patients is the largest such sample group examined by MRI. METHODS Patients were examined by means of imaging methods (42 patients by MRI and 4 by CT). All had an identical protocol of MR examination (T2WI, FLAIR, T1WI with or without application of contrast medium and T2WI/FFE, DWI in the transversal plane of the scan, and with focus on the optic nerves in the coronal plane of the scan in T2WI-SPIR). RESULTS Imaging methods revealed a positive finding associated with methanol intoxication in 21 patients (46%). These consisted of symmetrical lesions in the putamen--13 patients (28%), haemorrhage--13 cases (28%), deposits in white matter with localization primarily subcortically--4 cases (9%), lesions in the region of the globus pallidus--7 cases (15%) (in 6 cases without combination with the lesions in the putamen), les...
Abstract: Alcohol intoxication can present in many forms leading to diagnostic dilemmas. In this review, we examine both CT and MRI acute and chronic imaging patterns of ethanol and methanol toxicity. In acute ethanol intoxication, we delineate imaging findings of Wernicke's Encephalopathy, Marchiafava Bignami, Osmotic Demyelination Syndrome and Acute Hepatic Encephalopathy with attention to characteristic CT and MRI imaging features of each entity. We similarly illustrate distinguishing imaging characteristics of Acute Methanol Intoxication. We also delve into chronic ethanol poisoning by focusing on Chronic Acquired Hepatic Encephalopathy and Seizure Like Syndromes. Finally, we elucidate CT and MRI imaging features of Chronic Methanol Poisoning as it can manifest as multiple sclerosis mimics. In addition to detailing the distinct imaging features, we also correlate these entities with their respective physiology. In doing so, we hope to achieve accurate diagnosis for the betterment of patient care.
Imaging Findings in Methanol Intoxication
American Journal of Neuroradiology
We present the CT and MR imaging findings in acute methanol intoxication in a 35-year-old man who was admitted to the emergency department with weakness, blurred vision, mild bilateral areactive mydriasis, and a progressive decrease in the level of consciousness. CT and MR imaging showed bilateral putaminal hemorrhagic necrosis and subcortical white matter lesions with peripheral contrast enhancement. There was only partial improvement in patient's Glasgow Coma Scale score during follow-up.
Role of Imaging in Acute Methanol Intoxication -A Case Series
Methanol is a clear, colorless, highly toxic volatile liquid with an odour and taste similar to ethanol. Acute methanol poisoning produces sever metabolic acidosis and serious neurological symptoms. CT (Computed Tomography) and MRI (Magnetic Resonance Imaging) are able to demonstrate toxic effects of methanol intoxication in the CNS (Central Nervous System) including putaminal necrosis with or without hemorrhage and pathologies involving subcortical white matter, hippocampus, optic nerve, tegmentum, cerebral gray matter and cerebellum. Here we present three cases demonstrating different CNS changes demonstrated in MRI.
Histopathological and imaging modifications in chronic ethanolic encephalopathy
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2014
Chronic abuse of alcohol triggers different types of brain damage. The Wernicke-Korsakoff syndrome gets together Wernicke's encephalopathy and Korsakoff's syndrome. Another type of encephalopathy associated with chronic ethanol consumption is represented by the Marchiafava-Bignami malady or syndrome, an extremely rare neurological disorder, which is characterized by a demielinization of corpus callosum, extending as far as a necrosis. Because the frequency of ethanolic encephalopathy is increased and plays a major role in the sudden death of ethanolic patients, we have studied the chronic ethanolic encephalopathy both in deceased and in living patients, presenting different pathologies related to the chronic ethanol consumption. The present study investigated the effects of chronic ethanolic encephalopathy on the central nervous system based both on the histopathological exam of the tissular samples and the imaging investigation, such as MRI and CT.
Methanol intoxication: Diffusion MR imaging findings
European Journal of Radiology Extra, 2007
We present diffusion MR imaging findings and ADC values in acute methanol intoxication in a 32-year-old man. T2-weighted and FLAIR images showed bilateral increased signal in the caudate nuclei, putamen, cerebral peduncle, and centrum semiovale. Diffusion MR showed hyperintensity in same localization, and splenium of corpus callosum. ADC values of these areas were markedly reduced consistent with restricted diffusion.
Neuroimaging in Alcoholism: Ethanol and Brain Damage
Alcoholism: Clinical and Experimental Research, 2001
This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The co-chairs were Karl Mann and Ingrid Agartz. The presentations were (1) Neuropathological changes in alcohol-related brain damage, by Clive Harper; (2) Regional brain volumes including the hippocampus and monoamine metabolites in alcohol dependence, by Ingrid Agartz, Susan Shoaf, Robert R, Rawlings, Reza Momenan, and Daniel W Hommer; (3) Diffusion tensor abnormalities in imaging of white matter alcoholism, by Adolf Pfefferbaum and Edith V. Sullivan; (4) Use of functional MRI to evaluate brain activity during alcohol cue exposure in alcoholics: Relationship to craving, by Raymond F. Anton, David J. Drobes, and Mark S. George; and (5) -Opiate receptor availability in alcoholism: First results from a positron emission tomography study,
NeuroToxicology, 2020
Background: Basal ganglia lesions are typical findings on magnetic resonance imaging (MRI) of the brain in survivors of acute methanol poisoning. However, no data are available on the association between the magnitude of damaged brain regions, serum concentrations of markers of acute methanol toxicity, oxidative stress, neuroinflammation, and the rate of retinal nerve ganglion cell loss. Objectives: To investigate the association between MRI-based volumetry of the basal ganglia, retinal nerve fibre layer (RNFL) thickness and prognostic laboratory markers of outcomes in acute methanol poisoning. Methods: MRI-based volumetry of putamen, nucleus caudatus and globus pallidus was performed and compared with laboratory parameters of severity of poisoning and acute serum markers of oxidative damage of lipids (8isoprostan, MDA, HHE, HNE), nucleic acids (8−OHdG, 8−OHG, 5−OHMU), proteins (o-Thyr, NO-Thyr, Cl-Thyr) and leukotrienes (LTC4, LTD4, LTE4, LTB4), as well as with the results of RNFL measurements by optic coherence tomography (OCT) in 16 patients with acute methanol poisoning (Group I) and in 28 survivors of poisoning two years after discharge with the same markers measured within the follow-up examination (Group II). The control group consisted of 28 healthy subjects without methanol poisoning. Results: The survivors of acute methanol poisoning had significantly lower volumes of basal ganglia than the controls. The patients with MRI signs of methanol-induced toxic brain damage had significantly lower volumes of basal ganglia than those without these signs. A positive correlation was found between the volume of putamen and arterial blood pH on admission (r = 0.45; p = 0.02 and r = 0.44; p = 0.02 for left and right putamen, correspondingly). A negative correlation was present between the volumes of putamen and acute serum lactate
The value of brain CT findings in acute methanol toxicity
European Journal of Radiology, 2010
Objective: Due to depressant effects of methanol on the central nervous system, brain computed tomography (CT) scan has been introduced as a diagnostic device in methanol intoxication. The authors aimed to present brain CT findings in patients with acute methanol intoxication and to determine signs associated with death. Materials and methods: This cohort study involved 42 consecutive patients with acute methanol intoxication. Inclusion criteria were consisted of characteristic clinical presentation of methanol poisoning, and metabolic acidosis with increased anion and osmolar gaps. Brain CT scans without contrast medium were obtained. To determine the association between the CT findings and death, the chi-square test or the Fisher's exact test, odds ratio (OR) and its 95% confidence interval (95% CI) were calculated. Results: Twenty-eight patients (66.6%) had a total of 55 abnormal findings on brain CT, in which bilateral putaminal hypodense lesions was the most common manifestation (27 cases, 96.4%). Putaminal hemorrhage with varying degrees was observed in 7 patients (25%). Six patients (21.4%) had low attenuation lesions in the subcortical white matter of the insula. A significant association was observed between putaminal hemorrhage (OR = 8, 95% CI = 1.187-53.93, P = 0.018) and subcortical necrosis of the insula (OR = 11, 95% CI = 1.504-80.426, P = 0.007) with death. Conclusion: In addition to clinical and laboratory findings, presence of putaminal hemorrhage and insular subcortex white matter necrosis are associated with a poor clinical outcome in patients with methanol poisoning.