Seroprevalence of Chikungunya Virus Infection in an Urban Slum Population of Bangladesh: A Cross-Sectional Study (original) (raw)
Related papers
BIRDEM Medical Journal
Background: Chikungunya is a rapidly spreading viral infection of global concern. Initial presentation of chikungunya infection is often indistinguishable from other viral infections. In Bangladesh, chikungunya is an emerging infection. In this report, we describe socio-demographic, clinical and laboratory characteristics of chikungunya in a selected group of Bangladeshi patients. Methods: A multi-center descriptive study was done including adult patients with chikungunya virus infection from July 1, 2017 to October 31, 2017. Diagnosis of chikungunya virus infection was confirmed by reverse transcriptase polymerase chain reaction (RT-PCR) or immunoglobulin M (IgM) against chikungunya. Results: Total patients were 107 including 61 (57%) males. Mean age of the study participants was 35.6 (range 19-84) years. Ninety three (86.9%) patients presented with fever and 14 (13.1%) patients (with history of recent fever) presented due to joint pain. Most (93, 86.9%) patients were managed as ou...
Tropical Medicine and Health, 2022
Background Chikungunya is a severely debilitating disease. Bangladesh witnessed one of the largest outbreaks in 2017. Here, we described the clinical profile of the chikungunya outbreak in Bangladesh and its heterogeneity across three hotspots. Methods This was a descriptive cross-sectional study of 432 individuals interviewed from the outpatient department of three study sites (Dhaka, Chittagong, and Sitakundu Upazilla of Bangladesh) after confirmation by the study physicians. Both laboratory-confirmed cases and probable cases were recruited between July and October 2017. Results Of all, 18% (79) were laboratory confirmed, and 353 82% (335) were probable cases. The male:female ratio was almost equal (1.09:1), and the predominant age group was 18–59 years. The mean age of the presentation was 36.07 ± 13.62 (SD) years. Fever and arthralgia were the most common presentations and were present in > 95% of cases. Other frequent symptoms were fatigue, myalgia, headache, nausea, and vom...
International Journal Of Community Medicine And Public Health
Background: The first major outbreak in Bangladesh was reported in 2008 in Rajshahi and Chapainawabgonj. It then re-emerged in 2013, 2014 and 2015 mostly in Dhaka and other parts of Bangladesh, with a notable outbreak in December 2016 according to a report. It is a statistical report on the data retrieved from chikungunya patients in the Chittagong area, specifically in relation to age, gender, location, symptoms and to assess the magnitude of the outbreak with an interest in identifying the potential socio-environmental factors which may be responsible for chikungunya in respect to Chittagong.Methods: Collection of reports from well-established diagnostic laboratories, as well as, limited survey data during July to December, 2017. There were 188 clinically suspected chikungunya cases in both genders ranging from 2-70 years of age.Results: The total chikungunya cases in the study area it has been found that the highest number of cases were found in the age group of 41-50 years (25%)...
Seroprevalence of Chikungunya during Outbreak in Dhaka, Bangladesh in 2017
Journal of Virology & Antiviral Research, 2018
Chikungunya (CHIK) infection is re-emergence public health problem globally including Bangladesh. It is an arthropod-borne disease, which is transmitted by mosquitoes bite. The virus was first isolated in Newala district of Tanzania in 1953. In 2017, an outbreak of Chikungunya, has struck Bangladesh's capital, Dhaka. This study was conducted to know the seroprevalence, clinical presentations and seasonal trends of CHIK infection. This study was conducted in the Ibn Sina Diagnostic & Consultation Center, Uttara from January to November, 2017. Serum samples from about 1060 Chikungunya suspected cases were tested for immunoglobin M (IgM) and IgG antibodies by Immuno-Chromatographic test (ICT) method. Out of total tested cases, 524 (49.43%) were seropositive for Chikungunya, among the seropositive 379 (72.32%) were IgM positive, 98 (18.70%) were IgG positive and 47 (8.96%) were both IgM and IgG positive. The most affected age group was 11 to 40 years. Females were more affected than males. A high percentage of Chikungunya seropositive cases were found among suspected patients.
Journal of National Institute of Neurosciences Bangladesh, 2019
Background: Chikungunya virus was introduced into the Dhaka city of Bangladesh and triggered a massive outbreak which affected millions of lives and forced upon significant damages in socioeconomic factors. Objectives: This community based descriptive study was conducted in selected area of Dhaka city to see the clinical profiles of chikungunya patients in Dhaka city. Methodology: This prospective observational study was carried out in the Department of Medicine OPD at Shaheed Suhrawardy Medical College & Hospital (ShSMC), Dhaka, Bangladesh. This cross-sectional study was conducted during the peak of chikungunya outbreak (1st March to 31st August, 2018) to document the clinical profiles of confirmed cases (laboratory test positive) and probable cases diagnosed by medical practitioners. Results: The study included 1133 patients (Male 51.9%and Female 48.1%). The main symptoms were Fever (66%), higher in patients with Joint pain (82%), Rash (21.3%) and others (10.1%).Sensitivity of the...
Seroepidemiology of Chikungunya Fever in Dhaka, Bangladesh: A Crosssectional Study
Bangladesh Journal of Microbiology, 2022
Chikungunya fever (CHIKF) is a mosquito-borne febrile illness caused by the Chikungunya virus (CHIKV). Bangladesh has documented several outbreaks of CHIKF since it was first reported in 2008. The latest CHIKF outbreak occurred in the Dhaka in 2017. In this study, a serosurvey of the 2017 outbreak was conducted during its peak. The study involved the assessment of CHIKV immunoreactions among participants suffering from CHIKF related symptoms. One hundred blood samples were collected from patients suffering from CHIKF-associated symptoms and were subsequently tested for the presence of anti-CHIKV IgM and/or IgG antibodies. Data based on clinical symptoms and the demographics of the participants were recorded and analyzed. Seventy-four percent of the studied patients (n = 100) possessed anti-CHIKV antibodies. Among this seropositive group (n = 74), almost 62% contained anti-CHIKV IgM and IgG antibodies, whereas 10% contained only anti-CHIKV IgM antibodies indicating recent infection. ...
Chikungunya Outbreak in Bangladesh (2017): Clinical and hematological findings
A massive outbreak of Chikungunya occurred in Bangladesh during the period of April-September, 2017 and over two million people were at risk of getting infected by the virus. A prospective cohort of viremic patients was constituted and analyzed to define the clinical, hematological and long-term aspects of this outbreak. A 35-day long comprehensive survey was conducted in two major, neighboring cities, Dhaka and Mymensingh. One-hundred and eighty-seven clinically proven Chikungunya cases were enrolled in the cross-sectional cohort study. Additionally, a smaller group of 48 Chikungunya patients was monitored for post-infection effects for 12 months. Clinical data revealed that a combination of fever and arthralgia (oligoarthralgia and/or polyarthralgia) was the cardinal hallmark (97.9% of cases) of the infection. Hematological analysis showed that, irrespective of age groups, hemoglobin level significantly decreased and erythrocyte sedimentation rate remarkably increased in Chikungun...
An Outbreak of Chikungunya in Rural Bangladesh, 2011
PLoS neglected tropical diseases, 2015
The first identified Chikungunya outbreak occurred in Bangladesh in 2008. In late October 2011, a local health official from Dohar Sub-district, Dhaka District, reported an outbreak of undiagnosed fever and joint pain. We investigated the outbreak to confirm the etiology, describe the clinical presentation, and identify associated vectors. During November 2-21, 2011, we conducted house-to-house surveys to identify suspected cases, defined as any inhabitant of Char Kushai village with fever followed by joint pain in the extremities with onset since August 15, 2011. We collected blood specimens and clinical histories from self-selected suspected cases using a structured questionnaire. Blood samples were tested for IgM antibodies against Chikungunya virus. The village was divided into nine segments and we collected mosquito larvae from water containers in seven randomly selected houses in each segment. We calculated the Breteau index for the village and identified the mosquito species....
Manifestations of Atypical Symptoms of Chikungunya during the Dhaka Outbreak (2017) in Bangladesh
The American Journal of Tropical Medicine and Hygiene, 2019
Chikungunya (CHIK) has emerged as a major public health concern worldwide. Recently, atypical manifestations are drawing special attention because these might be associated with various complications. Information on atypical manifestations of CHIK is still limited. Here, we analyzed a dataset of 1,326 cases from our recent Dhaka outbreak study to explore the demographics and distributions of atypical manifestations. About 80% of cases reported at least one atypical symptom. Among all atypical symptoms, the most common and unique atypical symptom was joint pain before fever (90.2%), occurred predominantly in female respondents. Other common symptoms included red eye (68.2%), oral ulcer (37.7%), and dermatological manifestations (27.1%). More than two-thirds of patients reported multiple atypical symptoms. Atypical manifestations were not significantly different across age groups, except ocular complications. This study would be an important resource for clinicians and epidemiologists...
2010
Prevalence of chikungunya in the city of Ahmedabad, India during the 2006 outbreak was investigated to estimate the prevalence of suspected chikungunya cases to find out demographic parameters and proportion of various symptoms among suspected chikungunya cases, and to evaluate the effectiveness of control measures implemented by the public health sector. A total of 6667 people from 1301 households were surveyed. The prevalence of suspected chikungunya cases was 32.9% (31.8% - 34.2%). Prevalence was higher in females (p<0. 006), and also highest for the age group of 40 to 80 years. The north zone of the city, a densely populated slum, had significantly higher (p<0.001) numbers of suspected cases than the other zones. Case numbers were significantly higher in slums than in more affluent settings such as apartments and bungalows (p<0.001). Chills, headaches, joint swelling and itching were the main symptoms reported by the majority of cases. The majority (67.6%) of suspected ...