Use of Platelet rich plasma in chronic wounds by a quantification protocol (original) (raw)
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Platelet-Rich Plasma (PRP) for the Treatment of Problematic Skin Wounds
Journal of IMAB - Annual Proceeding (Scientific Papers), 2016
OBJECTIVE: To show analysis of the results of applying the method platelet-rich plasma (PRP) for the treatment of problematic skin wounds. The paper's objective is to prove its reliability and relevance, to evaluate its efficiency and applicability to Bulgarian patients. MATERIAL AND METHODS: Out of a total of 154 hospitalized patients with problematic skin wounds 83 have been treated with platelet-rich plasma, comprising the Experimental group (EG), and 71 patients with similar wounds have been treated by using traditional methods for the respective pathology at the Department of Orthopedics and Traumatology, Vessel and Plastic Surgery Department, comprising the Control Group (CG). Data on the condition of monitored symptoms of researched cases was collected for the research. A variable is defined for every symptom and its value and weight is correspondingly introduced. Scores introduced by Cancela AM are used for the assessment of the respective wound. Each of these scores is used for assessing specific wound parameters: Total Wound Score (TWS); total anatomic score (TAS) of wound and Total Score of Wound data (TSWD). RESULTS: Analysis of variance was performed to achieve the objectives and solve the research tasks; variables containing information on initial and final data from each series of experiments have been analyzed in order to determine basic numerical characteristics of variables, and by comparative analysis to check how they tend to vary in experimental (EG) and control (CG) group. Statistical survey shows that the platelet-rich plasma method gives significant results when treating problematic skin wounds leading to full recovery as compared to traditional methods typical for the pathology. The graphical interpretation allows to identify forecast relations between assessed aspects of problematic wounds and weeks of treatment. CONCLUSION: By analyzing the results of our study we can conclude that the use of platelet-rich plasma to treat problematic skin wounds is a safe and effective treatment method. It is not universal for every wound, but follows the principles of biological wound treatment and leads to full recovery of high percentage of problematic skin wounds. We support proponents of the application of platelet-rich plasma to treat problematic skin wounds.
Ostomy/wound management, 2010
Chronic wounds are characterized by a long inflammatory phase that hinders regenerative wound healing. The purpose of this prospective case series was to evaluate how a physiologically relevant concentration of an autologous platelet-rich plasma (PRP) gel affects initial wound healing trajectories of chronic, nonhealing wounds of various etiologies and in different care settings. Using convenience sampling methods, 49 patients (average age: 60.6 years, SD 14.7) with 65 nonhealing wounds (mean duration 47.8 weeks, range 3 to 260) at eight long-term acute care (LTAC) hospitals and three outpatient foot or wound clinics who were prescribed PRP gel for their nonhealing wound were enrolled. The majority of patients had low albumin, hematocrit, and/or hemoglobin levels. After wound assessments and measurements were obtained and the gel prepared, a skin barrier was applied to the periwound skin and the gel applied and protected with cover dressings. The most common wounds were pressure ulc...
Journal of Clinical Medicine
Background: Chronic wounds place a heavy burden on the healthcare system due to the prolonged, continuous need for human resources for wound management. Our aim was to investigate the therapeutic effects of platelet-rich plasma on the treatment of chronic wounds. Methods: The systematic literature search was performed in four databases. Randomized clinical trials reporting on patients with chronic wounds treated with platelet-rich plasma (PRP) were included, comparing PRP with conventional ulcer therapy. We pooled the data using the random effects model. Our primary outcome was the change in wound size. Results: Our systematic search provided 2688 articles, and we identified 48 eligible studies after the selection and citation search. Thirty-three study groups of 29 RCTs with a total of 2198 wounds showed that the odds for complete closure were significantly higher in the PRP group than in the control group (OR = 5.32; CI: 3.37; 8.40; I2 = 58%). Conclusions: PRP is a safe and effect...
"Clinical Study on Platelet Rich Plasma in Wound Healing"
IOSR Journals , 2019
Introduction: wound management is a challenging task to the surgeon and a debilitating issue to the patients. The general treatment including the expert care in dressings, meticulous use of antibiotics, Negative pressure vacuum therapy dressings, surgical interventions and reconstructions using a lot of resources, expenses and expert hands. But the results are still unpredictable and unassured. Platelet-rich plasma (PRP) has a numerous number of growth factors, chemokines, cytokines and many other proteins which have a numerous number of properties out of which one is its role in wound healing. Materials and Methods: The PRP therapy consists of self-activated autologous platelet-rich plasma derived from centrifugation of whole blood by Double centrifugation method. It is given as a local subcutaneous infiltrate along the wound margins on every fourth day till the wound is completely healed with regeneration of skin or red healthy granulation tissue. The study consisted of 30 patients, ages ranging from 20 to 60, both males and femaleswho were studied from January 2017 to december 2018.Hb per cent below 9 was a contraindication. The wounds consisted of both acute and chronic, including compound fractures, infected wounds, non-healing ulcers. Results: 28 wounds were healed by this technique which did not require any further procedures and two of them required split skin grafting. The average number of sittings required were seven. Antibiotic cultures showed no bacterial growth during the course of treatment. Conclusion: platelet-rich therapy is a novel mode of treating wounds by their growth factor properties and antibacterial properties giving satisfying results without wasting resources nor need of any other complex and expert techniques in wound
Role of Platelet Rich Plasma [PRP] in the Treatment of Chronic Wounds
International Journal of Contemporary Medical Research [IJCMR], 2018
Introduction: Chronic leg ulcers pose a formidable challenge to the surgeon necessitating various treatment modalities. Due to recurrence in wounds with conventional therapy, newer modalities of treatment with PRP showed promising results in various branches of medicine like plastic and reconstructive surgery, orthopedics, and dermatology, cardiovascular and thoracic surgery. Study aimed to record the effect of platelet rich plasma in the treatment of chronic ulcers particularly venous and diabetic leg ulcers. Material and methods: A prospective study of 10 cases of chronic leg ulcers. Chronic leg diabetic ulcers, venous foot ulcers of more than 3 months duration both males and females with normal platelet count and activity are selected. Age group between 18ys and 60 yrs with ulcers between size varying 2x2cm 2 to 10 x10 cm2 were included. Results: Wounds were measured on day O along their greater dimensions and were recorded, which ranged from 3x3 cm2 to 10x8. At the end of 2nd week, ulcer size had reduced by an average of 21.87% (range 0%-60%) in 10 wounds. Healing of the ulcers with full re-epithelialization was seen in 4 cases (40%). Of the remaining ulcers, 6 (60%) were taken up for skin grafting once the ulcer has granulated well. In these cases of skin grafting, 5 ulcers have healed completely with 1 case of graft failure Time taken for the wounds to heal completely by re-epithelization ranged from 6 weeks (1 venous ulcer) to 16 weeks (1 diabetic foot ulcer). Of the ulcers (n=6, 60%) which underwent skin grafting, 5 (83.33%),healed completely, with 1 case of graft fail. Conclusion: The use of platelet-rich plasma can be an option when treating recalcitrant wounds of differing etiologies.
Management of Wounds of Peripheral Arterial Disease Using Platelet Rich Plasma
Journal of Evolution of Medical and Dental Sciences
BACKGROUND Arterial ulcers are caused by inadequate perfusion of skin and subcutaneous tissues. The key treatment is correcting the underlying medical problem and re-perfusion of the affected tissue. Interventional procedures like angiography, transluminal angioplasty, and stenting have hazards like bleeding, hematoma formation, false aneurysm formation etc. This study was conducted to investigate the effect of platelet-rich plasma (PRP) on the rate of healing of peripheral arterial wounds. METHODS A randomized controlled trial was conducted with 80 participants admitted with peripheral arterial disease in Acharya Vinoba Bhave Rural Hospital, Wardha district, Maharashtra, from September 2017-August 2019. Data was entered into MS Excel and was analysed for descriptive statistics. 40 patients each were allotted randomly to control group and treatment group. In the control group, conventional dressings was done with hydrogen peroxide and betadine. Wounds were treated with PRP infiltration in the treatment group. Outcome was compared between both groups. RESULTS Mean surface area of wound in control group reduced from baseline 2262.5 mm 2 to 1758.4 mm 2 (29.89% reduction) in ulcer surface area, and 2298.9 mm 2 to 1158.1 mm 2 (66.22% reduction) in treatment group (p= 0 at the end of study) at the end of two months. Standard deviation of the same (Control: 1739.2 mm 2 to 1566.3 mm 2 vs Treatment: 1906.5 mm 2 to 1402.4 mm 2). Rate of epithelization was faster in treatment group (8.92 mm 2 /day vs 17.27 mm 2 /day, p=0 at the end of study). PRP resulted in early healing of ulcers with earlier reduction in wound surface area.
Management and effect of platelet-rich plasma on wound healing: small reality of Oglio Po Hospital
Acta Bio Medica : Atenei Parmensis, 2017
Platelet Rich Plasma (PRP) represents a relatively new approach in regenerative medicine. Its use is increasing in the treatment of a variety of orthopedic conditions, such as the management of acute wounds, chronic non-healing lesions, acceleration of bone formation, tendinopathy and chondropathy. The Orthopaedic Unit at Oglio Po Hospital uses PRP Gel in wound care since 2008. More than 70 patients have been treated with this procedure. The aim of this study is to show our patients outcome. We present 3 cases of severe traumatic wound treated with our PRP protocol. The patients had complete healing of the lesion with good aesthetic results.
Advances in Skin & Wound Care, 2011
OBJECTIVE: This study investigated clinical outcomes in chronic nonhealing wounds following the short-term use of an enhanced, near-physiological concentration of platelet-rich plasma (PRP) gel (AutoloGel System, Cytomedix, Inc, Gaithersburg, Maryland). DESIGN: Study design was a large, observational case series using a multicenter registry database (all wounds included), which compared different populations within the database. SETTING: Thirty-nine centers contributed to the registry, including long-term acute-care centers, outpatient clinics, a durable medical equipment company, a home health agency, and a long-term-care center. PATIENTS: The target population included 285 chronic wounds (patient n = 200). Wound etiologies included diabetic, pressure, or venous ulcer; dehisced, surgical, or traumatic wound; and wounds of other etiologies. INTERVENTION: Therapeutic, PRP gel is produced from patient blood utilizing autologous platelets and plasma that contribute growth factors, cytokines, and chemokines, in a fibrin matrix. MAIN MEASURES: Area and volume of the wound and the linear total of undermining and sinus tracts/tunneling were calculated. Clinical relevance was determined by analyzing outcomes in wounds that responded to treatment. MAIN RESULTS: A positive response occurred in 96.5% of wounds within 2.2 weeks with 2.8 treatments. In 86.3% of wounds, 47.5% area reduction occurred, and 90.5% of wounds had a 63.6% volume reduction. In 89.4% undermined and 85.7% of sinus tracts/tunneling wounds, 71.9% and 49.3% reductions in linear total were observed, respectively.
Investigation of Mean Platelet Volume as a Prognostic Criterion in Non-Healing Wounds
Acta Medica, 2022
Objective: We aimed to evaluate if the Mean Platelet Volume (MPV) is an acute phase reactant in non-healing wounds, by analyzing its correlation with Erythrocyte Sedimentation Rate (ESR). Method: Our study was carried out in a descriptive type with the participation of patients with non-healing wounds. The laboratory data and characteristics of the patients were accessed retrospectively, and the obtained data were recorded in the data recording form. Results: The sample group consisted of 92 patients with non-healing wounds. 26.9% of the patients with non-healing wounds had pressure sores, 37.6% of them had diabetic foot wounds, 18.3% had non-healing wounds developed after trauma, and 17.2% had necrotizing fasciitis. The average age of the patients was 53.22±19.13, and the average length of stay in the hospital was 108.98±18.78 (min 3 months, max 6 months) days. The MPV value, which was found to be high in the early stages of non-healing wounds, decreased after the wound was complet...