Topical oxygen therapy for diabetes‐related foot ulcers: A systematic review and meta‐analysis (original) (raw)

Diabetic Medicine, 2021

Abstract

IntroductionTopical oxygen therapy (TOT) has been suggested as a treatment for diabetes‐related foot ulcer (DFU) but no prior meta‐analyses of randomised clinical trials (RCT) have been reported. This systematic review and meta‐analysis examined the randomised evidence for the benefit of TOT in healing DFU.MethodsPublicly available databases were searched for RCTs investigating the effect of TOT on wound healing in participants with a DFU. The primary outcome was ulcer healing defined as full epithelialisation. Meta‐analyses were performed using random effect models and reported as risk ratios (RR) and 95% confidence intervals (CI). Study quality and publication bias were assessed using a modified version of the Cochrane Collaboration's tool and funnel plots, respectively.ResultsSix RCTs involving 530 participants with a DFU testing TOT were included. Meta‐analysis suggested that TOT significantly increased the likelihood of ulcer healing compared to controls (Risk ratio [RR] 1....

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