Versatility of nanosuspension formulation in various drug delivery systems: A brief review (original) (raw)

2020, Advance Pharmaceutical Journal

Nano suspension formulations are attractive, encouraging and consist purely poor water soluble drugs without any matrix material. Nano suspension technology solved the problem of poorly aqueous soluble and less bioavailability is also overcome by using this technology. Nanosuspension formulation is applicable to all aqueous insoluble drugs. The objective behind this study is to review the work done on nanosuspensions and recent drugs used to formulate this dosage form with their uses. The formulation of nanosuspensions include drugs, stabilizers, organic solvents and other additives such as buffers, salts, polyols, osmogents and cryoprotectant. Nanosuspension formulations are synthesized by using wet mill, high-pressure homogenizer, emulsion-solvent evaporation, melt emulsification method and supercritical fluid techniques. Nanosuspensions can be administered by oral, parenteral, pulmonary and ocular routes. It can also be used for targeted drug delivery when incorporated in the ocular inserts and mucoadhesive hydrogels. This review article describes the nanosuspensions, their preparation methods, characterization, and recent applications of the nanosuspension.