Development and Validation of Telmisartan in Tablet Dosage Form by RP-HPLC Assay Technology (original) (raw)

A simple, selective, rapid, precise and economical reverse phase high-pressure liquid chromatographic method has been developed as per ICH nomination for Development and Validation of Telmisartan in Tablet Dosage form By RP-HPLC Assay Method. The assay method was carried out by using a mobile phase consisting of Buffer Solution and Solution A ((Methanol and Acetonitrile (1:1)) in the gradient ratio. The detection was carried out by using HPLC Shimadzu LC with UV-Visible PDA at 298nm.The column was Hypersil BDS C-8 (12.5 cm X 4.0 mm, 5 µ). The flow rate was selected as 1.2ml/min. The retention time of Telmisartan was found to be 8.3 min respectively. The developed method was validated in terms of specificity, accuracy, precision, linearity and system suitability. The optimized proposed method easy to handle and commercially used for the routine quality control checking of Telmisartan pharmaceutical combine tablets dosage form.