Inhibition of Uterine Contractions of Premature Labour with an Oxytocin Analogue (original) (raw)

A competitive inhibitor of the action of oxytocin on the uterus, 1-deamino-2-D-Tyr-(OEt)-4-Thr-8-Orn-oxytocin, was studied for the first time in 13 patients with established, uncomplicated premature labour. Intravenous infusion of 1C100 ygimin of the analogue was given for 1-10 h and the effect was monitored by external cardiotocography. In all women an inhibition of uterine activity was observed. and in the majority of patients infused with 25 pggimin and a total dose of about 5 mg or more of the drug total inhibition of uterine contractions was achieved. There were no effects on the maternal and fetal pulse rates, nor were there any other side-effects. The results of this preliminary study support the concept of an increased concentration of uterine oxytocin receptors being aetiologically important in uncomplicated premature labour. They also suggest that the present oxytocin antagonist could be an interesting therapeutic alternative in the condition, primarily because of the marked selectivity of its effect. The mechanism of prcmaturc labour is in moct cases unclear. This has lead to the use of a variety of non-specific therapies, e.g. ethanol, 0,-adrenoceptor stimulants, prostaglandin synthesis inhibitors. calcium antagonists and mag