Relation of Severity of Maternal Hypothyroidism to Cognitive Development of Offspring (original) (raw)
Related papers
2018
Introduction: The focus of the present study was the importance of the mother's thyroid function for foetal development in the first trimester, when the baby is totally dependent on the mother for thyroid hormones. Materials and methods: The study consisted of testing the intellectual performance of children with both euthyroid and thyroid-dysfunction mothers. The experimental group comprised 60 children of mothers with an untreated thyroid disorder in the first trimester of pregnancy (TSH ≥ 3.5 mlU/L [standard 0.15-3.5] and/or TPO-Ab ≥ 20 lU/L [standard < 20]). The control group contained 132 children whose mothers showed no symptoms of a thyroid disorder either before or during pregnancy/postpartum. Both groups of children were administered the Wechsler Intelligence Scale for Children-Third Edition (WISC-III), whereby the intellectual performance of the experimental-group children was compared with that of the control-group children. The comparison included the percentage of children with IQ ≤ 85 and SLD and/or ADD risks. Our research is a follow-up to a blanket thyroid screening of 1649 pregnant women conducted during 2004-2006 in the region around Havlíčkův Brod. Results: The research found no significant difference between the two groups of children with respect to their intellectual abilities, either regarding their overall IQ (p = 0.67), verbal IQ (p = 0.81), performance IQ (p = 0.41), or the individual scores (VCI: p = 0.85; POI: p = 0.54, FDI: p = 0.57; PSI: p = 0.13), nor did the experimental group show a significantly higher occurrence of children with IQ ≤ 85 than the control group (p = 0.66). However, the experimental group did exhibit a statistically significant increase in the percentage of children with a suspected SLD or clinically significant attention issues (p = 0.05). Conclusion: Untreated thyroid disorders in the first trimester of pregnancy can increase the risk of the child developing attention or learning issues.
International Journal of Pediatrics, 2019
Background: Congenital hypothyroidism (CH) is one of the preventable causes of intellectual disability. The aim of this study was to compare intelligence quotient (IQ) in early treated children with CH and healthy children.Methods: This cohort study was conducted on 78 early treated children with CH (patient group) identified in screening program in Qazvin, Iran, from 2006 and 90 age and sex matched healthy children (control group). The Persian version of Wechsler scale was performed to assess IQ (full scale, verbal, performance). Full scale score among 70 and 80 were defined as borderline IQ and score among 50 and 69 were defined as mild mental retardation. Data were analyzed using SPSS software version 16.Results: Mean age was 6.57±1.92 in patients group and 6.94±1.57 in control group (P>0.05). 46/78 of the patient group and 51/90 of the control group were male (P>0.05). Mean full scale (87.01±13.47 vs. 107.45±10.49; P< 0.001), verbal (85.73±13.54 vs. 106.86±10.18; P< ...
Medical Journal of the Islamic Republic of Iran, 2020
Background: The clinical suspicion of Congenital Hypothyroidism (CH) is identified by abnormal results in the first test of Thyroid Stimulating Hormone (TSH) (5-9.9 mIU/L), and normal results in re-test (TSH<4 mIU/L). The CH has a contribution to physical and mental health. This study aimed to determine the Intelligence Quotient (IQ) score in children with suspected congenital hypothyroidism. Methods: This research is a retrospective cohort study conducted in Mashhad, Iran. The IQ scores of 1976 children at the age of 6 were considered as an outcome variable. The history of CH screening for each newborn was assessed, then all suspected CH newborns that diagnosed healthy in re-test were considered as an exposed group, the effects of this situation on IQ score was assessed using logistic regression. All analysis was performed in STATA. Results: The averages of IQ score (p<0.001), weight (p=0.024), and height (p<0.001) in the exposed group were lower than the unexposed group. ...
Intellectual outcome in children with fetal hypothyroidism
The Journal of Pediatrics, 1987
Intellectual outcome fetal hypothyroidism in children with Eighty children with congenital hypothyroidism detected by newborn screening were grouped for presence of fetal hypothyroidism using skeletal maturity at the time of diagnosis as the index. Forty-five children with bone age <36 weeks were assigned to the delayed group; 35 with bone age 37 weeks to term were assigned to the nondelayed group. Although most children with athyroSis were found in the delayed group, the groups did not differ in birth weight, hormone levels, or family background. Assessments of intellectual and behavioral characteristics at 1, 2, 3, 4, and 5 years of age revealed that, although children in the delayed group performed within the normal range, their scores were significantly lower than those of the nondelayed group from age 2 years on. Perceptual-motor, visuaspatial, and language areas were most affected. There were no differences in behavior or temperamental characteristics.
Archives of Endocrinology and Metabolism
Clinical and subclinical hypothyroidism are the most common hormonal dysfunctions during pregnancy. Insufficient maternal thyroid hormones (THs) in the early stages of pregnancy can lead to severe impairments in the development of the central nervous system because THs are critical to central nervous system development. In the fetus and after birth, THs participate in neurogenic processes, cell differentiation, neuronal activation, axonal growth, dendritic arborization, synaptogenesis and myelination. Although treatment is simple and effective, approximately 30% of pregnant women in Brazil with access to prenatal care have their first consultation after the first trimester of pregnancy, and any delay in diagnosis and resulting treatment delay may lead to cognitive impairment in children. This review summarizes the effects of clinical and subclinical hypothyroidism on fetal neurodevelopment, behavior and cognition in humans and rodents.
Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2013
Considering the high prevalence of congenital hypothyroidism (CH) in Isfahan, the intelligence quotient (IQ) of children with CH and the effect of diagnostic and treatment variables on it were investigated during the CH screening program. A total of 120 children in three studied groups were studied in this comparative study the IQ score, in three subsets of verbal IQ, performance IQ and full scale IQ, of children diagnosed with transient congenital hypothyroidism (TCH) and permanent congenital hypothyroidism (PCH) was measured using revised Wechsler pre-school and primary scale of intelligence and compared with the control group. The relation between IQ score with time of treatment initiation and screening thyroid stimulating hormone (TSH) level was evaluated in all studied groups. Mean of verbal IQ, performance IQ, and full scale IQ score was significantly higher in the control group than CH patients (both permanent and transient) In PCH patients though it was not significant, ther...
Intellectual outcome at 12 years of age in congenital hypothyroidism
European Journal of Endocrinology, 1999
Background: The intellectual outcome in children with congenital hypothyroidism detected by neonatal screening is generally good; however, subtle neurological dysfunctions, subnormal IQ, or both, have been reported. Objective: To evaluate the intellectual outcome in 12-year-old patients with congenital hypothyroidism, detected by neonatal screening, in an attempt to identify factors that may affect intellectual development.