Structures of HIV TAR RNA-Ligand Complexes Reveal Higher Binding Stoichiometries (original) (raw)

ChemBioChem, 2009

Abstract

Target TAR by NMR: Tripeptides containing arginines as terminal residues and non-natural amino acids as central residues are good leads for drug design to target the HIV trans-activation response element (TAR). The structural characterization of the RNA-ligand complex by NMR spectroscopy reveals two specific binding sites that are located at bulge residue U23 and around the pyrimidine-stretch U40-C41-U42 directly adjacent to the bulge.

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