The genome-wide dynamics of the binding of Ldb1 complexes during erythroid differentiation (Genes & Development (2010) 24, (277-289)) (original) (raw)

The binding dynamics of the Ldb1 complex, which includes the transcription factor Gata1 and interacts with negative regulators Eto2 and Mtgr1, play a critical role in erythroid differentiation. This study employs genome-wide analysis to demonstrate that the Ldb1 complex primarily functions as a positive activator, showing specific binding patterns related to promoter types and facilitating genomic interactions. Findings emphasize the shedding of negative regulators, underscoring the Ldb1 complex's essential role in the final stages of erythroid cell development.