Study of Carotid Intima Media Thickness as a Predictor of Macrovascular Complications in Type 2 Diabetes Mellitus (original) (raw)
Related papers
2012
Background: Diabetes mellitus is a widespread disease. Its vascular complications can be characterized by arteriosclerosis formation in carotid arteries. Due to its delayed diagnosis resulting in more complications in Iran, it seems that screening diabetic patients is mandatory. Objectives: The aim of this study was to compare the intima-media thickness (IMT) of carotid artery in diabetic and non-diabetic patients. Patients and Methods: This is a cross-sectional study, which included 80 participants (40 diabetics and 40 non-diabetics). By using ultrasound, bilateral IMTs of the distal carotid were measured and the data were analyzed using ANOVA and multivariate regression tests in SPSS 14. Results: The mean IMT was 0.97 in diabetic patients and 0.63 in non-diabetics (P < 0.001). Age and gender had significant positive effects on the increase of IMT (P < 0.05 and P < 0.005, respectively for age and gender). Past medical history of coronary heart disease (CHD) and cerebrovascular accident (CVA) in diabetes is associated significantly with an increase in IMT (P =0.019 and 0.027 respectively). Other confounding variables such as smoking, history of hypertension (HTN) and hyperlipoproteinemia (HLP) in diabetic patients showed no significant relationship with the increase of IMT. Conclusions: Although measuring the IMT of the carotid artery by sonography is a useful tool for screening diabetic patients, more studies are needed for determining how to use these measurements in promoting the patients outcomes.
Arteriosclerosis, Thrombosis, and Vascular Biology, 2003
Objective— We examined whether B-mode ultrasound–detected carotid artery intima-media thickness (IMT) was elevated before the onset of clinical diabetes. Methods and Results— The study population for these analyses included 1127 nondiabetic participants, 66 prediabetic participants, and 303 diabetic participants with a mean age of 49.8 years who participated in the Mexico City Diabetes Study, a prospective cohort study. Common carotid artery (CCA) and internal carotid artery (ICA) IMTs were measured bilaterally by B-mode ultrasound. Age- and sex-adjusted mean ICA and CCA IMTs were both significantly higher among prediabetic individuals {0.81 mm [95% confidence interval (CI), 0.75–0.88] and 0.72 mm [95% CI, 0.69–0.75], respectively} than in individuals who remained free of diabetes [0.71 mm (95% CI, 0.69–0.72) and 0.69 mm (95% CI, 0.68–0.69), respectively]. However, after adjustment for established cardiovascular risk factors, ICA IMT, but not CCA IMT, remained significantly higher a...
JPMA. The Journal of the Pakistan Medical Association, 2016
To compare carotid Intima media thickness and atherosclerosis burden amongst healthy, diabetic and hypertensive Pakistani patients. A cross-sectional study was carried out at the Department of radiology and family medicine, Aga Khan University Hospital Karachi from April 2014 to July 2015. Bilateral carotid ultrasound was done in 133 healthy adults, 65 hypertensive, 31 type-2 diabetic and 37 hypertensive with type-2 diabetes patients. Normal adults were matched for age and gender. Mean intimal media thickness was measured for common and internal carotid arteries. Presence or absence of atherosclerotic plaque was also identified. Height, weight, ethnicity, socioeconomic status and other risk factors were also assessed. Ultrasound findings were compared between healthy and diseased patients through statistical tests. A total of 266 patients participated (Controls=133, Hypertensive=65, Diabetic=31, and Diabetes with Hypertension=37). There was no significant difference in the baseline ...
Journal of Evidence Based Medicine and Healthcare, 2017
BACKGROUND The Framingham study pointed out that diabetic individuals have dyslipidaemia and hypertension, obesity are more prone to metabolic syndrome and its sequelae namely coronary artery disease (CAD), cerebrovascular disease and vascular atherosclerosis. 1 Carotid intima media thickness (CIMT) is a relatively simple, non-invasive measurement that uses ultrasound to detect the presence of an extent of atherosclerosis. Normal CIMT is 0.9 mm. Aims and Objectives: 1. To evaluate the carotid intima media thickness in 100 patients of type 2 diabetes mellitus with its duration, hypertension, age and sex distribution and also lipid profile abnormalities. 2. To study the correlation of carotid intima media thickness with dyslipidaemia. MATERIALS AND METHODS 100 patients of type 2 diabetes mellitus getting admitted into medical wards of
Journal of Nepal Medical Association
Introduction: Sonographic carotid intima media thickness measurement in diabetic patients is an important tool for estimating the risk of cardiovascular and cerebrovascular events. It is a simple, noninvasive and widely available tool which can give idea of further treatment needed. The objective of this study was to determine the mean intima media complex thickness in patients with type II diabetes mellitus attending a tertiary care center. Methods: This was a descriptive cross-sectional study done in 64 patients with the type II diabetes mellitus patients visiting diabetic clinic of Tribhuvan University Teaching Hospital, sent for carotid Doppler examination in the department of radiology and imaging. Ethical approval was taken from the Instituitonal Review Board. Convenient sampling method was used. Carotid intima media thickness was measured on both sides and mean intima media thickness was calculated. Mean intima media thickness for male and female diabetic patients was also ca...
Carotid Intima Media Thickness in Diabetic and Non Diabetic Subjects : A Study from Rural Hospital
2015
Atherosclerosis typically occurs over a period of many years, usually many decades. After a generally prolonged “silent” period, atherosclerosis may become clinically manifest. Evaluation of intima media thickness is considered as surrogate marker of Atherosclerosis. B mode ultrasound was found to be a suitable non invasive method to visualize the arterial walls and to monitor the early stages of the atherosclerotic process. Purpose of this study was to find out carotid intima media thickness in patients with diabetic and non diabetic patients and its correlation with associated risk factors like age, sex, hypertension, and smoking. A total of 100 patients were selected with 50 patients each in diabetic and non diabetic groups. Study protocol included detailed clinical history, clinical examination and investigations. Patients were subjected for carotid doppler examination and other relevant investigations pertaining to their clinical status. The mean intima media thickness values o...
International Journal of Advanced Research in Medicine, 2019
Background: Diabetes mellitus refers to a group of common metabolic disorders that share the phenotype of hyperglycemia. The present study was conducted to determine carotid intima-media thickness in patients of controlled and uncontrolled type 2 diabetes mellitus. Materials and Methods: The present study was conducted on 150 type 2 diabetes mellitus patients (75 in controlled diabetes and 75 in uncontrolled diabetes group) of both genders. All patients underwent carotid doppler of common carotid artery determined by higher resolution B mode ultrasonography using Philips Affinity 70 machine. The total of 3 values was averaged to give mean common carotid intima-media thickness value for each patient. Results: Group I had 40 males and 35 females whereas group II had 45 males and 30 females. The mean diameter of right CCA in group I was 6.4 mm and in group II was 7.3 mm, in left CCA was 6.5 mm and in group II was 6.8 mm, right ICA was 4.5 mm in group I and 4.7 mm in group II and left ICA was 4.6 mm in group I and 4.5 mm in group II. The mean IMT of right CCA in group I was 0.72 mm and in group II was 0.84 mm, in left CCA was 0.74 mm and in group II was 0.87 mm, right ICA was 0.43 mm in group I and 0.48 mm in group II and left ICA was 0.45 mm in group I and 0.54 mm in group II. Conclusion: Authors found increase diameter and thickness of intima media in uncontrolled diabetics as compared to controlled diabetics.
Journal of advanced research in medicine, 2018
Diabetes Mellitus is a chronic, common metabolic disorder characterised by high blood sugar levels over a prolonged period. Atherosclerosis involving the coronary, cerebral and peripheral (lower extremity) arteries is the predominant cause of diabetes related mortality, responsible for up to 70% of all deaths in patients with this disease. Coronary angiography (CAG) has been considered as the gold standard for the assessment of the degree of Coronary atherosclerosis but measurement of carotid intima thickness by ultrasonography is a non invasive and quantitative method of evaluating early atherosclerosis. The aim of this study was to assess carotid artery intima media thickness and to assess any correlation between carotid artery intimal thickness and coronary artery disease in Type II DM. This study was carried out in the department of medicine, Dr. Baba saheb Ambedkar hospital, Delhi to assess carotid intima media thickness (CIMT) as a risk factor for CAD in type II diabetes using Ultrasound B scan to assess CIMT. In this study, 30 patients of DM type II with CAD, 30 patients of DM type II without CAD & 30 patients were age and sex matched controls who did not have any disease. Mean CIMT was found to be significantly increased in DM type 2 with CAD group as compared to DM type 2 without CAD and the difference was found to be statistically significant (P<0.001). Also the mean CIMT was significantly increased in DM type 2 with and without CAD as compared to controls and the difference was statistically significant. Also, patients with more than 3 cardiovascular risk factors had significantly greater CIMT than patients who had less than 3 cardiovascular risk factors and the difference was statistically significant.
International journal of diabetes in developing countries, 2009
Patients with type-2 diabetes mellitus have greater carotid intima media thickness and they are at risk for generalized atherosclerosis. This study aimed to compare the thickness of carotid artery intima media in type-2 diabetes mellitus patients with and without nonblood pressure component metabolic syndrome. This was a comparative observational study conducted in the Departments of Pharmacology and Physiology in the College of Medicine, Al-Mustansiriyia University in cooperation with Baghdad Teaching Hospital. Forty-six diabetic patients of both sexes with systolic blood pressure < 130 mm Hg and diastolic blood pressure < 85 mm Hg were subjected to high resolution B-mode ultrasonography of the common and internal carotid arteries. Patients were grouped into those without metabolic syndrome (Group I) and with nonblood pressure component metabolic syndrome (Group II). The two-tailed unpaired Student's t-test was used in this study. Significantly high mean thickness was obs...