The possible anti-inflammatory properties of hydro-ethanolic extract of Oregano (original) (raw)
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Bio-efficacy of the essential oil of oregano (Origanum vulgare Lamiaceae. Ssp. Hirtum)
Plant foods for human nutrition (Dordrecht, Netherlands), 2014
The aim of this study was to investigate the bioactivity of the essential oil isolated from Origanum vulgare L. (EOv). We analyzed the in vivo anti-inflammatory properties in a mouse-airway inflammation model and the in vitro antimicrobial activity, genotoxicity over the anaphase-telophase with the Allium cepa strain and its cytotoxicity/viability in A549 culture cells. In vivo, EOv modified the levels of tumor necrosis factor -α and viable activated macrophages and was capable to mitigate the effects of degradation of conjugated dienes. In vitro, EOv reduced the viability of cultured A549 cells as well as the mitotic index and a number of chromosomal aberrations; however, it did not change the number of phases. We found that EOv presents antimicrobial activity against different Gram (-) and (+) strains, measured by disc-diffusion test and confirmed with a more accurate method, the AutoCad software. We postulate that EOv presents antibacterial, antioxidant and chemopreventive proper...
IN VIVO ANTI-NOCICEPTIVE AND ANTI-INFLAMMATORY PROPERTIES OF ORMENIS MIXTA L. FOM MOROCCO
International Journal of Pharmacy and Pharmaceutical Sciences, 2016
Objective: Ormenis mixta L. (Asteraceae) is a traditional herbal medicine widely used as a mild sedative, spasmolytic and antibacterial agent. This paper aimed to examine possible anti-inflammatory and antinociceptive effects of Ormenis mixta L. in rodents. Methods: Anti-inflammatory effect of Ormenis mixta L. was investigated with the carrageenan and experimental trauma-induced hind paw edema tests. Ormenis mixta L. essential oil (OMEO) by gavage at 100 and 200 mg/kg and aqueous extract (OMAE) at 200 and 400 mg/kg, were administered and compared with indomethacin, and control group. Antinociceptive effects of both extracts were evaluated using acetic acidinduced writhing and tail immersion tests and compared with standard drug (morphine and aspirin). Results: It was found that pretreatment with OMEO and OMAE significantly (P<0.05) reduced paw swelling and diminished the nociceptive response in rodents. Conclusion: Ormenis mixta L. essential oil and aqueous extract have a potent anti-inflammatory and an antinociceptive properties
Current Pharmaceutical Design, 2019
Background: Origanum vulgare is used in Armenian cuisine as well as in folk medicine. The aim of this investigation was to determine the peculiarities of the chemical composition of Armenian flora’s oregano essential oil (EO) and ethanol extract (EE) and to characterize mainly antioxidant and antibacterial properties in vitro. Methods: EO of plant aerial parts was extracted by the hydro-distillation method, and the composition was analyzed by gas-chromatography (GC). EE was prepared using ethanol as a solvent. Antioxidant, antibacterial and other biological activity of EO and EE was determined using appropriate methods. Results: The terpenes were found to be the greatest part of oregano EO (β-caryophyllene epoxide - 13.3 %; β- caryophyllene -8.2 %; ο-cymene - 5.2 %). The flavonoid content of EE was 3.9±0.7 mg g-1 catechin equivalents. Antiradical activities of EO and EE expressed with half-maximum inhibitory concentrations were 1057 µg mL-1 and 19.97 µg mL-1. The antioxidant index i...
2018
Oregano (<i>Origanum vulgare</i> L.) is a common aromatic plant used in Mediterranean and Asian Regions for treating respiratory diseases, painful menstruation, rheumatoid arthritis, etc. Recently its role as an anticancer plant has been suggested, although oregano has been never evaluated into adrenocortical tumour cell models. This study analysed for the first time the anticancer effects of a crude extract of wild mountain oregano (<i>Origanum vulgare</i> L.) in SW13 and H295R cell lines. The crude extract was characterised by GC/MS and the toxic effects of oregano were first analysed by brine shrimp lethality assay. Our findings demonstrated that oregano decreased cell viability, survival, modified cell cycle and induced cell death (through necrotic process) and that the effects can be attributed to a blockade of MAPK and PI3 K/Akt pathways. These results suggest that oregano extract exerts anticancer activities in adrenocortical tumour cell lines, providi...
Systematic Reviews in Pharmacy, 2020
Angiogenesis is the formation of new blood vessels and is required in tumor growth, metastasis and cancer progression. Philippine traditional medicine preparations have shown a comprehensive and function- regulating characteristics. Oregano (Origanum vulgare) is an annual succulent herb which distributed throughout the world. Currently, there have been some related reports on the preventive effects on chronic diseases such as cancer and heart diseases with oregano. The study aimed to evaluate the antiangiogenic activity of oregano crude leaf extract through Chick Chorioallantoic Membrane (CAM) assay. The density and length (per branching) of the blood vessels were measured through a microscope and ToupView software calibrated using a micrometre respectively. The researchers analyzed the data gathered using one-way Analysis of Variance (ANOVA), post hoc tests were also performed using Duncan Multiple Range Test (DMRT) to confirm the results of the ANOVA. Statistical results in the me...