Radiation-Induced Angiosarcoma After Mastectomy and TRAM Flap Breast Reconstruction (original) (raw)

Related papers

Case Report: Post-radiation Angiosarcoma and Bilateral Mastectomy

2002

We report the occurrence of bilateral angiosarcoma after radiation therapy for breast carcinoma in a 64 yr-old woman. The first angiosarcoma developed 17 yr after radiation therapy to the right breast; the second angiosarcoma developed 1.5 yr after radiation therapy to the left breast. Recognizing angiosarcoma in radiated breast tissue is essential to appropriate therapy. The role of irradiation after surgery as adjuvant therapy is to be reviewed. (received 8 April 2002; accepted 20 May 2002)

Cutaneous angiosarcoma as a delayed complication of radiation therapy for carcinoma of the breast

Journal of The American Academy of Dermatology, 2003

Three cases of cutaneous angiosarcoma of the breast that arose in irradiated skin tissue in women who had previously undergone treatment for breast carcinoma are reported. A review of the literature identified 55 cases of cutaneous angiosarcoma following radiation therapy as part of the treatment of carcinoma of the breast. For all 58 assembled cases, the mean age at the time of adjuvant radiation therapy for breast carcinoma was 64 years (range 42-83). The mean time to subsequent diagnosis in irradiated skin was 75 months (range 12-192). The estimated 3-year overall survival for all 58 patients was only 20%, similar to that of patients with the general form of angiosarcoma. Postirradiation angiosarcoma of the breast has a variety of presentations; thus diagnosis is often delayed. Early diagnosis relies on a high index of suspicion and appropriate histopathologic studies, as the clinical and histopathologic findings may be confused with other conditions. Treatment should be aggressive and include local surgery with consideration of adjuvant systemic chemotherapy.

Post-radiation angiosarcoma and bilateral mastectomy

Annals of clinical and laboratory science, 2002

We report the occurrence of bilateral angiosarcoma after radiation therapy for breast carcinoma in a 64 yr-old woman. The first angiosarcoma developed 17 yr after radiation therapy to the right breast; the second angiosarcoma developed 1.5 yr after radiation therapy to the left breast. Recognizing angiosarcoma in radiated breast tissue is essential to appropriate therapy. The role of irradiation after surgery as adjuvant therapy is to be reviewed.

Radiation-Induced Angiosarcoma of the Breast: Case Report and Review of the Literature

MOH Journal of Medical Case Reports, 2024

Radiation-induced angiosarcoma (RIAS) of the breast is a rare aggressive malignancy following radiotherapy for the treatment of a previous breast condition. We present a case of a 49-year-old female who developed RIAS after treatment of breast ductal carcinoma by lumpectomy and postoperative radiation. The RIAS developed at the site of the prior breast carcinoma. The diagnosis of RIAS was challenging and required extensive immunohistochemistry (IHC) studies to rule out all other possible differential diagnoses, including benign and malignant conditions. The patient underwent a total mastectomy as the primary surgical intervention, followed by a regimen of postoperative chemotherapy to target any residual cancer cells and reduce the risk of recurrence. After three years of rigorous follow-up, the patient remains free of disease, showcasing the effectiveness of the combined surgical and chemotherapeutic approach in managing this challenging tumor. This case underscores the importance of vigilant long-term monitoring and a multidisciplinary treatment strategy in improving outcomes for patients with post-radiation breast angiosarcoma.

Radiation-Associated Angiosarcoma of the Breast: Clinical and Pathologic Features

Archives of Pathology & Laboratory Medicine, 2016

Breast angiosarcoma is an unusual malignancy accounting for approximately 1% of soft tissue sarcomas. It can occur as a primary form without a known precursor or as a secondary form associated with radiotherapy. Adjuvant radiotherapy has a significant role in preventing local recurrence in women treated with conservation therapy for early stage breast carcinoma or multicentric tumors. Postradiation angiosarcoma usually affects the dermis of the breast within the radiation field and may occasionally develop in the breast parenchyma. Compared with the latency of other radiation-associated sarcomas, the latency for breast radiation-associated angiosarcoma is relatively short with a median of 6 years. The risk of developing secondary angiosarcoma does not outweigh the benefit of treatment; therefore, radiation therapy continues to be a mainstay modality in the treatment of breast cancer patients. Early detection is essential because angiosarcomas are associated with a poor prognosis. Wi...