Concentration of biliary metal elements and gallstone formation in humans (cholelithiasis) (original) (raw)

Trace Elements and Electrolytes, 2002

Abstract

Metals in the human body are metabolized mainly via the kidney and liver and excreted through urine and partly by bile. Changes in the composition of bile may induce cholecystitis and cholelithiasis. For the study of the effect of metal elements in the bile on gallstone formation, element concentration in the gallstone (cholesterol and mixed pigment stones) and bile samples were measured. The samples were digested with a mixture of HNO 3 (5 ml) and H 2 O 2 (3 ml) in teflon vessels. The concentration of 23 elements (Al, As, B, Ba, Ca, Cd, Co, Cr, Cu, Fe, Hg, K, Li, Mg, Mn, Mo, Na, Ni, P, S, Ti, V, Zn) in the bile fluid and gallstone samples were determined by inductively coupled plasma optical emission spectrometry (ICP-OES). The concentration of Cd, Hg, Li and V in the bile and V in the gallstone samples was below the detection limit in each case. Significant correlation was found between the concentration of Al-Ca (r=0.985), P-Mg(r=0.891), S-Mg(r= 0.893) in bile and Al-Ca (r = 0.98...

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