Verrucous herpetic disseminated lesions in AIDS patients (original) (raw)

European Journal of Dermatology, 1995

Abstract

This article describes 2 patients with acquired immunodeficiency syndrome (AIDS) who in the last 6 months of their terminal phase developed painful, disseminated hyperkeratotic skin lesions, biopsies of which revealed histological aspects of verrucous epidermal hyperplasia with dyskeratotic cells and multinucleated cells of Unna. The patients had recently had disseminated herpes virus infections. The patient who presented the greater number of relapses and who had been treated with long-term oral acyclovir in prophylactic doses suffered from a skin eruption which was unresponsive to this drug, resolving only with intravenous Foscarnet. We review AIDS cases with chronic verrucous eruptions attributed to herpes varicellazoster virus (VZV) infection some of which were acyclovir resistant. We also make reference to the appearance of identical lesions secondary to other DNA viruses in these patients

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