Acute disseminated encephalomyelitis after mumps infection in a vaccinated patient (original) (raw)
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Acute disseminated encephalomyelitis after mastoid surgery in a child
The Journal of Laryngology & Otology, 2007
We present a case of acute disseminated encephalomyelitis after mastoid surgery in an 11-year-old child. The aim of this paper is to increase awareness about a previously unreported and an unusual neurological complication of cholesteatoma and mastoid surgery.
Encephalomyelitis following mumps
Spinal Cord, 2005
Method: A 22-year-old male patient diagnosed and treated as mumps encephalomyelitis is described. The clinical findings of the patient and the difficulties in differential diagnosis are discussed with the help of previously reported eight adult cases. Results: Increased T2 signals in the spinal cord from C4 to C6 and T5 to T10 were seen by magnetic resonance imaging. This was the largest spinal involvement in the reported mumps cases. He was treated with supportive therapy oral steroids and early rehabilitation. On the sixth month, his neurological examination revealed bilateral 2/5 paresis in lower extremities. Conclusion: Encephalomyelitis following mumps is an uncommon but serious event in adults. , 441-444.
An Adult Case of Mumps Brainstem Encephalitis
Internal Medicine, 2000
Wepresent an adult case of mumps brainstem encephalitis. He was successfully treated with steroid pulse therapy and recovered completely except for persistent dysuria. He had not been vaccinated and had no history of acute mumps infection. Weconsider that encephalitis in this case was caused by a reversible autoimmuneprocess triggered by mumps infection. Weemphasize the usefulness of pulse therapy for the treatment of somecases of mumps brainstem encephalitis in addition to the importance of mumpsvaccination to prevent such a severe complication as encephalitis.
Bilateral Neuroretinitis Associated With Mumps
Archives of Neurology, 2002
Background: Involvement of the optic nerve is a rare complication of mumps infection. Objectives: To report a case of bilateral neuroretinitis complicating a mumps infection and to review 5 previously reported cases. Design: Case report and literature review. Setting: Tertiary hospital. Patient: A 7-year-old girl had sudden-onset blindness due to bilateral neuroretinitis. Approximately 3 weeks prior to the initial examination, she developed a selflimited febrile illness with parotid swelling and subsequent meningoencephalitis. Results: Mumps was determined to be the underlying cause of the meningoencephalitis and bilateral optic neuritis because of the exposure history in this nonvaccinated child, the typical clinical signs and symptoms, and the positive serologic test results. Recovery of visual function was gradual but nearly complete. Conclusions: Physicians should be aware that optic nerve involvement may be a manifestation of mumps infection. The delayed onset of optic neuritis, the bilateral involvement, and the near complete recovery suggest an immune-mediated pathogenesis.
Brain and Development, 2011
We describe for the first time an 8-year-old male patient who demonstrated clinically mild encephalitis with a reversible splenial lesion after mumps vaccination. He suffered from transient hallucinations, nuchal rigidity, and inappropriate antidiuretic hormone secretion syndrome. On the 5th day of admission, his head MRI showed symmetrical high-signal-intensity lesions on T2, FLAIR, and diffusion-weighted images in the splenium of the corpus callosum and in the periventricular white matter, while an apparent diffusion coefficient map showed reduced diffusion. The images were not enhanced by gadolinium. Follow-up MRI on the 16th day of admission revealed none of these abnormalities. His serum IgM and IgG antibodies against the mumps virus were positive according to an enzyme immunoassay. Mumps Torii vaccine strain was isolated from the patient's cerebrospinal fluid. Previous reports demonstrated that transient delirious behavior, the syndrome of inappropriate antidiuretic hormone secretion, and good prognosis were the main clinical features of mild encephalitis with a reversible splenial lesion. This case shows that mild encephalitis with a reversible splenial lesion could occur after mumps vaccination.
Clinically mild encephalitis with a reversible splenial lesion (MERS) after mumps vaccination
Journal of the neurological sciences, 2015
We retrospectively collected three patients with clinically mild encephalitis with a reversible splenial lesion (MERS) after mumps vaccination, and reviewed five patients, including two patients previously reported. The five patients (all males, aged 1 to 9) presented with fever, vomiting, or headache as the initial symptoms (day 0), suggesting meningitis, at 13 to 21 days after mumps vaccination. Consciousness disturbance, delirious behavior, seizures, or dysarthria was observed on days 1 to 3, which had completely resolved before day 11. Hyponatremia was observed in all patients. A cerebrospinal fluid study showed pleocytosis, and confirmed the vaccine strain genome. MRI revealed reduced diffusion in the splenium of the corpus callosum on days 2 to 4, which had completely disappeared on the follow-up studies performed on days 7-15. EEG showed high voltage slow wave in three patients, which later normalized. These findings led to a diagnosis of MERS after mumps vaccination. MERS af...
AIMS Medical Science, 2020
Despite the availability of safe, reliable, and cost-effective measles vaccine, we continue to experience dreadful measles outbreaks with devastating multisystem complications, especially in the pediatric age group. In most instances, the complications arise from a late presentation or delayed institution of appropriate care. With coexistence of measles virus and bacteria in the middle ear, suppurative otitis media can involve the mastoid process and causes fatal complications that manifest late when the patient is in a dire state. This short review highlights the pathogenic mechanisms leading to mastoiditis, facial paralysis, and neck abscess following acute infection with the measles virus, and outlines some useful diagnostic tips. In this review, we searched the international electronic database (PubMed, Web of Science, and Embase) and Google Scholar for articles published on complications of acute measles infection. The keywords used were "mastoiditis", "mastoid antrum", "middle ear", "otitis media", "Bezold's abscess", "facial paralysis" with an operator "OR"; "AND" measles; with restriction to the English language. Also, we searched for similar information in the local clinical and virology journals databases. Thereafter, we reviewed the publications and we described the findings qualitatively.
An unusual postoperative complication: anesthesia mumps
European Journal of Plastic Surgery, 2007
Anesthesia mumps is a unique clinical entity characterized by acute transient postoperative swelling of the parotid gland. Although there has been some reports in the literature of other surgical disciplines, there has been no report of anesthesia mumps in plastic surgical literature as yet. A 3year-old patient with anesthesia mumps after hypospadias repair is presented. To our knowledge, this case is the youngest patient of anesthesia mumps in the literature. In this article, the causes, differential diagnosis, and treatment of anesthesia mumps are discussed, and preventive measures are outlined.
Cases of aseptic meningitis after vaccination against mumps in Russia (2009–2019)
Public Health, 2020
Objectives: Mumps is a highly contagious viral infection prevented by immunization with live attenuated vaccines. Mumps vaccines have proven to be safe and effective; however, rare cases of aseptic meningitis (AM) can occur after vaccination. The range of meningitis occurrence varies by different factors (strain, vaccine producer, and so on). Monovaccines or divaccines (mumps-measles vaccine), prepared from the strain Leningrad-3 (L-3), are used in Russia. Meningitis occurrence after vaccination has been established previously as very low. Nevertheless, with the number of children being vaccinated every year, vaccineassociated AM cases still occur. There is no official statistics on AM incidence after mumps vaccines, and information on AM features as an adverse event of mumps vaccination is limited and mostly devoted to vaccines, prepared from strains other than L-3. Study design: The study included patients with AM who were vaccinated against mumps in the previous 30 days before the present disease onset during 2009e2019. Methods: Patients admitted to Infectious Clinical Hospital No. 1, Moscow, Russia, with AM were observed by a pediatrician and were screened for etiological agents of meningitis. Results: Seven patients were enrolled, and clinical features and the course of infection are presented. Conclusions: Detection of only 7 cases of AM associated with mumps vaccination during the 10-year period supports very low occurrence of this adverse event after immunization with the L-3 strain ebased mumps vaccines. Nevertheless, the annual number of AM cases that occur after mumps vaccination remains unknown and poorly diagnosed in practice because of the low awareness of physicians of this adverse reaction. Detection and objective coverage of such cases can lead to a weakening of 'antivaccination' moods in a society and to restoration of confidence in the healthcare system.