Obesity and disability in the symptomatic Irish knee osteoarthritis population (original) (raw)
Related papers
Romanian Journal of Rheumatology, 2024
Background. Musculoskeletal diseases like osteoarthritis (OA) are widespread. OA affects the knees, makes the joints wear out and hurt, and makes it hard to move around. Body mass index (BMI) is a way to measure obesity, which is linked to a higher chance of getting OA and making it worse. The main aim of this cross-sectional study was to find out how body mass index (BMI) is related to how lousy knee osteoarthritis is. Methods. One hundred people at the Shri Guru Ram Rai Institute of Medical and Health Sciences in Dehradun met the study's requirements and were enrolled. The Kellgren-Lawrence grading method was used to find the severity of knee osteoarthritis (OA), and standard measurements were used to calculate body mass index (BMI). A correlation study was done to examine the link between BMI and the severity of OA. Results. The sample included 100 participants on average of 60 years old. The typical knee OA symptoms lasted five years. A body mass index distribution analysis showed 35% obese, 40% overweight, and 25% underweight or average weight. Twenty percent of knee OA patients were mild, 35 percent intermediate, 30 percent severe, and 15 percent progressed. The association investigation revealed a significant positive correlation between BMI and knee osteoarthritis severity (r = 0.65, p < 0.001). Conclusion. Our results show that being overweight can worsen knee OA, proving that people with this problem need to watch their weight. If we treat obesity as a risk factor that can be changed, we might be able to improve the results of OA.
Obesity and knee osteoarthritis
Inflammopharmacology, 2012
Background The association between obesity and knee osteoarthritis, and specifically the role of obesity as a risk factor for knee osteoarthritis has been well documented. A systematic review and meta-analysis by Blagojevic et al. in Osteoarthr Cartil 18(1):24-33, (2010) examined 36 papers reporting on BMI and found that all studies demonstrated obesity and being overweight to be risk factors for knee osteoarthritis. The effect size for obesity as a risk factor for knee OA was reported to be I 2 = 97%, and the random effects pooled odds ratio for obesity compared to normal weight was 2.63 with a 95% CI of 2.28-3.05. Objective This review summarises recent findings involving the association between knee osteoarthritis and obesity: the potential mechanisms of the link between the two disease states; and the potential benefits of weight loss on obese, knee osteoarthritis patients. Methods Studies for inclusion in our report were identified using: MEDLINE; EMBASE; PUBMED; Cochrane Central Register of Controlled Trials; CINAHL; and reference lists of relevant articles. Main results A number of recent studies involving the association between obesity and knee osteoarthritis have since been published. A large, population-based prospective study (n = 823) conducted by Toivanen et al. with a follow-up of 22 years found that the risk for knee osteoarthritis was 7 times greater for people with BMI C30 compared to the control of people with BMI \25. A prospective cohort study of the Norwegian population by Grotle et al. that followed 1,675 patients reported that BMI [30 was significantly associated with osteoarthritis of the knee, with odds ratio of 2.81, and 95% CI of 1.32-5.96. Lohmander et al. found that in a large cohort study of 27,960 patients from the Swedish population, the relative risk for knee osteoarthritis (fourth quartile compared to first quartile) was 8.1, with a 95% CI of 5.3-12.4. Finally, a case-control study from Holliday et al. with 1,042 knee osteoarthritis patients and 1,121 matched controls reported that the adjusted odds ratio for knee osteoarthritis in patients with BMI [30 was 7.48 with 95% CI of 5.45-10.27.
Objective: the aim of our work was to study the effects of physical therapy versus weight reduction and their combined effects in obese patients with knee OA. Methods: 156 obese patients (137 females and 19 males) with knee OA were recruited. their BMIs ranged from 30.2 to 50.8. Patients were randomized to three groups: Group I: underwent physical therapy only. Group II: underwent weight reduction only. Group III: underwent combined physical therapy and weight reduction. Changes in body weight and body composition were examined as independent predictors of changes in knee OA symptoms. Symptoms were monitored by the Western Ontario and McMaster Universities? (WOMAC) OA index. Results: the mean changes of group II and III (-16.9 ?2.7 and -15.7 ?2) were highly significant respectively while mean change of group I (-0.6 ?0.4) was non significant. Group II had the best improvement of BMI with mean change of (-6.6 ?0.8) followed by group III (-4.9 ?0.7 ) while group I had the worst (-0.3 ?0.2) . The total WOMAC index improved within each group after two and four months from baseline (p < 0.001), The best mean change of WOMAC score was found in group III (-14.8 ?49). Conclusion: Combination of both weight reduction and physical therapy gives better results as regard improving knee pain and function in patients with OA, reduces disability and improves quality of life compared to each method alone.
Cureus, 2022
Instruction: Obesity is a health problem that is rapidly increasing both in local societies and internationally. It is well known that obesity has a risk relationship with many different diseases. The scale for obesity is Body Mass Index (BMI), which has been widely accepted worldwide for many years. The relationship between BMI and disease is a frequently studied topic. This study aimed to evaluate and measure knee function and pain in patients with knee osteoarthritis. Materials and Methods: A total of 100 patients in radiologically advanced stage (Kellgren/Lawrence grade 3-4) who were scheduled for knee arthroplasty were administered seven knee osteoarthritis scales (Timed up and Go (TUG), American Knee Society Score (AKSS),
Body Mass Index and predisposition of patients to knee osteoarthritis
Obesity Medicine, 2019
Introduction: Obesity is increasingly a prevalent comorbid with potentially substantial adverse effects on pre and postoperative outcomes on osteoarthritis patients. The ablative effect on the joint especially on the weight sustaining joints is the major consequence of osteoarthritis that causes pain and the obese are most susceptible. Methodology: A retrospective cohort study, using a non-probability convenience sampling method. A self-administered twelve item questionnaire on the perception of knee osteoarthritis was used to determine the relationship of obesity with the development of knee osteoarthritis among patients visiting the surgery outpatient clinic of Hospital Universiti Sains Malaysia HUSM. Obesity was described as BMI ≥30 mg/kg 2. Descriptive statistics were employed to describe the demographic data in frequency, mean, percentage, and standard deviation while independent T-Test was used to determine the association of obesity on the development of knee osteoarthritis. Results: From the questionnaire analysis, the result revealed that there is a significant mean difference (Pvalue = 0.001) of BMI among the osteoarthritis group. The mean BMI of patients in the osteoarthritis group 40.97 (SD 3.59) was higher than the mean BMI of patients in the group without osteoarthritis 31.29 (S.D 0.71). Furthermore, it was observed that the mean of the group with osteoarthritis was very high indicating that the population group is highly obese when compared to the groups without osteoarthritis, thus implying that the presence of osteoarthritis can be associated with increasing weight. Conclusion: Obesity is associated with the development of knee osteoarthritis, however, whether it starts or worsens osteoarthritis progression remains an inconsistent resolution, following these, more prudent research would be required to solve this quest.
Annals of the Rheumatic Diseases, 2009
Objective:To determine in a prospective population-based cohort study relationships between different measures of body mass and the incidence of severe knee and hip osteoarthritis defined as arthroplasty of knee or hip due to osteoarthritis.Materials and methods:Body mass index (BMI), waist circumference, waist–hip ratio (WHR), weight and percentage of body fat (BF%) were measured at baseline in 11 026 men and 16 934 women from the general population. The incidence of osteoarthritis over 11 years was monitored by linkage with the Swedish hospital discharge register.Results:471 individuals had knee osteoarthritis and 551 had hip osteoarthritis. After adjustment for age, sex, smoking and physical activity, the relative risks (RR) of knee osteoarthritis (fourth vs first quartile) were 8.1 (95% CI 5.3 to 12.4) for BMI, 6.7 (4.5 to 9.9) for waist circumference, 6.5 (4.6 to 9.43) for weight, 3.6 (2.6 to 5.0) for BF% and 2.2 (1.7 to 3.0) for WHR. Corresponding RR for hip osteoarthritis wer...
PLOS ONE
Objective To examine the risk of total knee arthroplasty (TKA) due to osteoarthritis associated with obesity defined by body mass index (BMI) or waist circumference (WC) and whether there is discordance between these measures in assessing this risk. Methods 36,784 participants from the Melbourne Collaborative Cohort Study with BMI and WC measured at 1990–1994 were included. Obesity was defined by BMI (≥30 kg/m2) or WC (men ≥102cm, women ≥88cm). The incidence of TKA between January 2001 and December 2018 was determined by linking participant records to the National Joint Replacement Registry. Results Over 15.4±4.8 years, 2,683 participants underwent TKA. There were 20.4% participants with BMI-defined obesity, 20.8% with WC-defined obesity, and 73.6% without obesity defined by either BMI or WC. Obesity was classified as non-obese (misclassified obesity) in 11.7% of participants if BMI or WC alone was used to define obesity. BMI-defined obesity (HR 2.69, 95%CI 2.48–2.92), WC-defined ob...
European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2018
The aim of this survey was to explore general practitioners' opinions and practices regarding the management of symptomatic knee osteoarthritis in obesity. Questionnaires were sent electronically to members of the Royal College of General Practitioners specialty interest groups: GPs with an Interest in Nutrition Group and the Physical Activity and Life Style group. The response rate was 75% (142/190). The majority stated weight loss should be the first-line treatment. Half stated that community interventions were effective, and three quarters stated that bariatric surgery should be available to these patients. Two-thirds reported that their knowledge and training around obesity management was insufficient. Our survey has shown a variation in the opinions and practices amongst respondents on the management of symptomatic knee osteoarthritis in obesity. Given the projected obesity epidemic, greater training and resources are required in the community setting to enable effective ma...
BMC Musculoskeletal Disorders, 2008
Background: Obesity is one of the most important risk factors for osteoarthritis (OA) in knee(s). However, the relationship between obesity and OA in hand(s) and hip(s) remains controversial and needs further investigation. The purpose of this study was to investigate the impact of obesity on incident osteoarthritis (OA) in hip, knee, and hand in a general population followed in 10 years. Methods: A total of 1854 people aged 24-76 years in 1994 participated in a Norwegian study on musculoskeletal pain in both 1994 and 2004. Participants with OA or rheumatoid arthritis in 1994 and those above 74 years in 1994 were excluded, leaving n = 1675 for the analyses. The main outcome measure was OA diagnosis at follow-up based on self-report. Obesity was defined by a body mass index (BMI) of 30 and above. Results: At 10-years follow-up the incidence rates were 5.8% (CI 4.3-7.3) for hip OA, 7.3% (CI 5.7-9.0) for knee OA, and 5.6% (CI 4.2-7.1) for hand OA. When adjusting for age, gender, work status and leisure time activities, a high BMI (> 30) was significantly associated with knee OA (OR 2.81; 95%CI 1.32-5.96), and a dose-response relationship was found for this association. Obesity was also significantly associated with hand OA (OR 2.59; 1.08-6.19), but not with hip OA (OR 1.11; 0.41-2.97). There was no statistically significant interaction effect between BMI and gender, age or any of the other confounding variables. Conclusion: A high BMI was significantly associated with knee OA and hand OA, but not with hip OA.
Background There is a discordance in classification of obesity when defined by body mass index (BMI) or waist circumference (WC). We aimed to examine whether categories of BMI- and WC-defined obesity are differentially associated with the risk of total knee arthroplasty for osteoarthritis. Methods 38,924 participants from the Melbourne Collaborative Cohort Study with BMI and WC measured at baseline (1990-1994) were included. Obesity status was defined as: not obese (non-obese BMI and non-obese WC); WC-defined obesity only (non-obese BMI and obese WC); BMI-defined obesity only (non-obese WC and obese BMI); and BMI- and WC-defined obesity. The incidence of total knee arthroplasty for osteoarthritis between January 2001 and December 2013 was determined by linking participant records to the National Joint Replacement Registry. Results Over 11.5±3.1 years follow-up, 1,875 participants underwent total knee arthroplasty for osteoarthritis. Participants with WC-defined obesity only (HR=1.79...