Adipocyte signaling affects thyroid-specific gene expression via down-regulation of TTF-2/FOXE1 (original) (raw)

Journal of Molecular Endocrinology, 2023

Abstract

Obesity affects thyroid gland function. Hypothyroidism, thyroid nodules, goiter, and thyroid cancer are more frequent in patients with higher body mass index values. Although these data are supported by many clinical and epidemiological studies, very scarce is our knowledge at the molecular level. In this study, we present the first experimental evidence that adipocyte signaling down-regulates the expression of thyroid-specific transcription factor 2 (TTF-2/FOXE1). It plays a crucial role in thyroid development and thyroid homeostasis and it is strictly connected to thyroid cancer as well. We provide in vivo and in vitro evidence that inhibition of TTF-2/FOXE1 gene expression is mediated by adipocyte signaling.

Donato Civitareale hasn't uploaded this paper.

Let Donato know you want this paper to be uploaded.

Ask for this paper to be uploaded.