Regulation of granuloma fibrosis by nitric oxide during Mycobacterium avium experimental infection (original) (raw)

The study investigates the role of nitric oxide (NO) in regulating granuloma fibrosis during Mycobacterium avium infection, highlighting the complex interplay between NO production and fibrotic responses. Utilizing a murine model, differences in collagen deposition and granuloma characteristics were examined between wild-type and iNOS-deficient mice. Results indicate that increased iNOS activity is associated with reduced fibrosis, suggesting potential therapeutic targets for managing granulomatous diseases.