Patients with Cystic Echinococcosis: Evaluation of Clinical and Biological Features of Cysts (original) (raw)

2022

Abstract

Objective: The main purpose of the study was to evaluate CE patients in a versatile way with the most commonly used diagnostic methods. In addition, we also investigated correlation between diagnostic parameters and CE cyst properties. Materials and Methods: A total 45 patients had an active or transitional CE cysts according to the WHO-IWGE classification and they have received percutaneous treatment for CE cysts. Serological analyses, molecular characterization of E.granulosus s.l. and direct examination of hydatid material were perfomed. Results: A total of 58 CE cysts were recorded and 34 of 58 hydatid cysts were identified as CE1, 14 as CE2, 2 as CE3a and 8 as CE3b. Direct examination, 30 of 58 hydatid cysts were found to be positive regarding protoscolex. According to serological tests, 37 of 45 patients had positive ELISA results. Most of the isolates (56/58) were identified as E.granulosus sensu stricto (G1-G3 genotypes) and two of them were characterized as E. canadensis (G6/7 genotypes). On the other hand, it is confirmed that serodiagnosis has been influenced by certain cyst characteristics. Conclusion: CE patients should be evaluated using many diagnostic approaches to accurate epidemiological information and to adopt proper clinical management.

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