Epidemiology of Dengue and Dengue Hemorrhagic Fever in a Cohort of Adults Living in Bandung, West Java, Indonesia (original) (raw)
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PLoS neglected tropical diseases, 2016
Dengue has emerged as one of the most important infectious diseases in the last five decades. Evidence indicates the expansion of dengue virus endemic areas and consequently the exponential increase of dengue virus infections across the subtropics. The clinical manifestations of dengue virus infection include sudden fever, rash, headache, myalgia and in more serious cases, spontaneous bleeding. These manifestations occur in children as well as in adults. Defining the epidemiology of dengue in a given area is critical to understanding the disease and devising effective public health strategies. Here, we report the results from a prospective cohort study of 4380 adults in West Java, Indonesia, from 2000-2004 and 2006-2009. A total of 2167 febrile episodes were documented and dengue virus infections were confirmed by RT-PCR or serology in 268 cases (12.4%). The proportion ranged from 7.6 to 41.8% each year. The overall incidence rate of symptomatic dengue virus infections was 17.3 case...
Clinical and virological characteristics of dengue in Surabaya, Indonesia
PloS one, 2017
Dengue disease is still a major health problem in Indonesia. Surabaya, the second largest city in the country, is endemic for dengue. We report here on dengue disease in Surabaya, investigating the clinical manifestations, the distribution of dengue virus (DENV) serotypes, and the relationships between clinical manifestations and the genetic characteristics of DENV. A total of 148 patients suspected of having dengue were recruited during February-August 2012. One hundred one (68%) of them were children, and 47 (32%) were adults. Dengue fever (DF) and Dengue hemorrhagic fever (DHF) were equally manifested in all of the patients. We performed DENV serotyping on all of the samples using real-time RT-PCR. Of 148, 79 (53%) samples were detected as DENV positive, with DENV-1 as the predominant serotype (73%), followed by DENV-2 (8%), DENV-4 (8%), and DENV-3 (6%), while 5% were mixed infections. Based on the Envelope gene sequences, we performed phylogenetic analyses of 24 isolates to geno...
2006
A prospective study of dengue fever (DF) and dengue haemorrhagic fever (DHF) in adults was conducted at two factories in Bandung, Indonesia, between August 2000 and July 2004. A total of 2978 employees were followed for the development of fever and clinical signs of DF/DHF. Among 1431 patients reporting a febrile illness, dengue infections were detected in 177 individuals. Four enrollees with evidence of previous dengue exposure experienced two consecutive episodes of dengue infection. Analysis of preillness sera revealed that one patient had neutralizing antibodies (nAbs) to DENV-1, two had nAbs to DENV-2, and another had nAbs to DENV-2, 3 and 4. The individual with pre-illness neutralizing antibodies to DENV-1 experienced a DENV-3 secondary infection, followed by a third infection with an unknown serotype. One of the two individuals with pre-illness neutralizing antibodies to DENV-2 experienced a DENV-3 and then a DENV-1 infection. The other DENV-2 immune patient experienced seque...
Circulation of Various Dengue Serotypes in Community Based Study in Jakarta, Indonesia
Japanese Journal of Infectious Diseases
Dengue virus (DENV) infection is still a serious health problem in Indonesia. Community based dengue study to determine circulated DENV in certain place and time is limited due to expensive cost and effort. Many DENV infected patients are not admitted to the hospital, and many patients come to the hospital at later phase of disease. In this study, we developed active DENV cases finding in the community in Jakarta to study circulating dengue serotypes where adult febrile patients with fever less than 48 hours were recruited. Disease severities were defined using the World Health Organization (WHO) 1997 guideline. Rapid NS1 dengue antigen detection were used to screen DENV patients in the community. Viral isolation in C6/36 cell line or increased antibody titer by HI and ELISA or RT-PCR were performed to confirm DENV infection.Viral serotype was investigated through RT-PCR. From 102 patients, 68 (66.7%) patients were confirmed DENV infection with DENV-2 is the most dominant serotype followed by DENV-3, DENV-1 and DENV-4, in concordance with several cases of mixed DENV infection. Interestingly, in terms of disease severity, although DENV-3 infection is not the predominant circulating serotype, but its infection tend to give more severe disease compare to DENV-2 infection.
The Overview of Dengue Hemorrhagic Fever in East Java During 2015-2017
Jurnal Berkala Epidemiologi, 2020
Background: Dengue Hemorrhagic Fever (DHF) is an infectious disease caused by the dengue virus which spreads more widely and the morbidity rate increases every year in East Java Province. DHF transmitting vector is widespread in residential areas and in public places, population density, population mobility, increasing urbanization. Purpose: This study aims to describe the number of cases, Incidence Rate (IR), Case Fatality Rate (CFR), and the peak incidence of DHF in East Java Province in 2015-2017. Method: This study is a descriptive approach study with a population that is all East Java residents who are at risk of suffering from dengue. This study uses a total population technique that involves all DHF cases recorded in the East Java Provincial Health Profile for 2015-2017. The data used are secondary data obtained from the Health Profile of East Java Province in 2015-2017, namely the number of DHF cases, gender, morbidity and mortality rates due to DHF. Data were analyzed using IR and CFR formulas. Results: The number of DHF cases in East Java in 2015 to 2017 fluctuated. DHF morbidity rates have increased in 2016 while 2017 has decreased. The mortality rate in East Java in 2015-2017 has decreased. DHF events often occur in male sex. Conclusion: DHF is a vector-borne disease with rapid spread. The occurrence of dengue hemorrhagic fever every year there is an increase in cases and deaths of almost all districts / cities in East Java.
Serotype infectivity and phylogenetic of dengue virus cause of dengue fever (DF), dengue hemorrhagic fever (DHF), and engue shock syndrome (DSS) in surabaya-Indonesia 1,5 Infection with DENV causes a spectrum of clinical disease ranging. The aim of this study is to investigate the infectivity of DENV with degree of severity dengue infection in Surabaya. Dengue infection was established by IgM anti dengue, and two step multiplex RT PCR and Nucleotide sequence. Grading of degree severity infection follow the WHO criteria 2011. DSS cases found 3 from 36 patients caused by DENV 2. The most uninfective was DENV 1, and the most prevalence dengue infection caused by DENV 3. The infectivity of dengue infection shown 16 patients lead to severity with plasma leakage. All of sera patients detecting using multiplex RT-PCR were positive, but it were analyzed using Duo ELISA only 22 serum sera positive IgM and IgG from 36 sera.. The Phylogenetic analysis indicates that the isolates from 2011 to 2...
The molecular and clinical features of dengue during outbreak in Jambi, Indonesia in 2015
Pathogens and Global Health, 2016
Dengue is hyperendemic in Indonesia. In 2015, reported cases of dengue fever doubled those of 2014 in the Jambi municipality of Sumatra. We examined viral aetiology and its relationship with disease outcome in Jambi. Denguesuspected patients' sera were collected and NS1 detection and IgM/IgG serology were performed. Dengue virus (DENV) serotyping was performed using real-time RT-PCR. Envelope genes were sequenced to determine the genotypes of DENV. Clinical, haematologic, and demographic data were recorded. Of 210 dengue-suspected patients, 107 were confirmed. The disease manifested as Dengue Fever (62%), Dengue Haemorrhagic Fever (36%), and Dengue Shock Syndrome (2%). The serotypes of 94 DENV were determined. All DENV serotypes were detected with DENV-1 as the predominant serotype (66%). Genotypically, the DENV-1 viruses belong to Genotype I, DENV-2 was of Cosmopolitan genotype, DENV-3 as Genotype I, and DENV-4 belonged to Genotype II. Comparison with historical data revealed serotype predominance switched from DENV-3 to DENV-1, and the replacement of Genotype IV of DENV-1 with Genotype I. In summary, DENV-1 predominated during the 2015 dengue outbreak in Jambi. The full spectrum of dengue disease occurred and was characterized by a switch in predominant serotypes.
BMC Research Notes
Objective: To provide a national incidence rate and case fatality rate of dengue hemorrhagic fever in Indonesia through an analysis of the National Disease Surveillance database from the Directorate General of Disease Prevention and Control of Ministry of Health. Results: Available data has indicated an increasing trend of dengue hemorrhagic fever incidence in Indonesia over the past 50 years. Incidence rates appear to be cyclic, peaking approximately every 6-8 years. In contrast, the case fatality rate has decreased approximately by half each decade, since 1980. Java Island contributed the highest average number of dengue hemorrhagic fever cases each year. In recent years, Bali and Borneo (Kalimantan) have had the highest incidence while Papua Island, the easternmost region of the Indonesian archipelago, has had the lowest incidence.
Epidemic Dengue Transmission In Southern Sumatra, Indonesia
Transactions of the …, 2001
An outbreak of dengue fever (DF), dengue haemorrhagic fever (DHF), and dengue shock syndrome (DSS) in the city of Palembang, south Sumatra, Indonesia was investigated to (i) validate epidemic occurrence, (ii) confirm dengue virus aetiology and associated serotype(s), (iii) provide a ...
TRANSMISSION OF EPIDEMIC DENGUE HEMORRHAGIC FEVER IN EASTERNMOST INDONESIA
In April 2001, a second suspected outbreak of dengue hemorrhagic fever in the easternmost region of Indonesia was investigated in Merauke, a town located in the southeastern corner of Papua, by the Indonesian Ministry of Health and the U.S. Naval Medical Research Unit No. 2. Principal case criteria of hemorrhagic disease provided for a study enrollment of 15 clinically acute and 37 convalescing subjects. Additionally, 32 comparable age/sex controls were selected from neighboring households. Laboratory diagnosis involved three testing methodologies: virus isolation by cell culture, a reverse transcriptase-polymerase chain reaction (RT-PCR) assay, and serologic assays. Antibody (IgM) to dengue virus was detected in 27% of the acute clinical cases, 30% of the convalescing cases, and only 3% of the matched controls. Dengue 3 was the only viral serotype detected from acute serum samples by the RT-PCR. The mean ± SD age of the acute and convalescing cases was 7.8 ± 5.4 years. Overall hospital records accounted for 172 suspected outbreak cases, all urban residents of Merauke with no recent travel history outside the area. The estimated outbreak-associated case fatality rate among all suspected dengue cases was 1.2%. A seven-year retrospective review of hospital records in Merauke showed negligible disease reporting involving hemorrhagic disease prior to the outbreak.