Total Antioxidant Capacity and Malondialdehyde in Depressive Rotational Shift Workers (original) (raw)
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Oxidative Stress and Depression among Male Shift Workers in Shahid Tondgouyan Refinery
Iranian journal of psychiatry, 2014
The aim of this study was to determine the oxidative stress; serum level of Total Antioxidant Capacity (TAC)and Malondialdehyde (MDA) level and the depression score among the depressed rotational shift workers in Shahid Tondgouyan Refinery in Tehran (Iran). A cross-sectional study was conducted among all the 189 shift workers in Shahid Tondgouyan oil refinery who were eligible to participate in the study. They did not take any antidepressants for two months or any supplements for two weeks prior to the study entry. Written consent was obtained from the participants. 21- Item Beck Depression Inventory was used to measure the depression level. Furthermore, body weight, height and systolic and diastolic blood pressure were collected from all the participants. The levels of Total Antioxidant Capacity (TAC) and Malondialdehyde (MDA) were measured by 8 ml fasting blood sample. MDA was determined by thiobarbituric acid reaction. Serum total antioxidants were measured using the spectrophoto...
Reliability of malondialdehyde as a biomarker of oxidative stress in psychological disorders
BioImpacts, 2015
Despite very wide variations of malondialdehyde (MDA) concentrations in biological samples, it is still used as a biomarker of oxidative stress in clinical investigations. In the current perspective study, we aimed to summarize a number of critical analytical points for determination of MDA. Technical problems and controversial findings in healthy people and some psychiatric disorders reveal that the reliability of MDA as a biomarker of oxidative stress needs to be re-evaluated by experts.
The effect of day and night shifts on oxidative stress and anxiety symptoms of the nurses
European review for medical and pharmacological sciences, 2012
Oxidative stress is believed to have a role in the development of chronic diseases. It is also known that long-term night and shift work in nurses might be associated with many health-related problems like fatigue, sleep problems, anxiety and difficulties in maintaining regular lifestyles. In this study, we aimed to evaluate the changes of oxidative stress parameters and anxiety indexes of the nurses on day and night shifts. One hundred and twenty nurses in ordinary service and intensive care unit (ICU) were enrolled to the study. Subjects were divided into 2 groups; group 1 (n = 60) consisted of nurses working in a day shift and group 2 (n = 60) as working in the night shift. Further, both groups were divided in to 2 groups again; group la and 2a (both n = 30) who working in the ICU, group 1b and 2b (both n = 30) in the ordinary service. Just before and the end of the shifts, blood samples were obtained to measure total antioxidant status (TAS) and total oxidant status (TOS). Oxida...
ABSTRACT Lack of sleep is associated with imbalance of oxidative stress biomarkers and the present study was to investigate the effect of sleep variation among undergraduate student of Ahmadu Bello University Zaria during and after the period of examination. The cross sectional study comprising of Undergraduate adult Males and females students of two to three hundred level of Faculty of Medicine were used for the experiment [(47 test group (during examinations) and 47 control group (after examinations)]. The study period extended to about 16 weeks. First phase from the beginning of the semester and the second phase during the examination period. Questionnaire were completed by the cohorts and blood sample of about 5 ml was collected from the cubital vein of each subject for these two phases of the study. At the end of the experimental protocol, antioxidant biomarkers level were assayed. The level of glutathione peroxidase (GPx) was significantly (P < 0.05) decreased during examination with values 47.42 ± 1.69 as compared with that after examinations period with values (49.87 ± 1.43*). Superoxide dismutase (SOD) shows significant increase during examination 18.63 ± 1.01 as compare with that value recorded after examinations 16.32 ± 1.04*. There is no significant changes in catalase activity. In conclusion, the present study demonstrate an increase in SOD level, decrease GPx level and insignificant changes in CAT with decrease in sleep.
Relationship between intensity of night shift work and antioxidant status in blood of nurses
International Archives of Occupational and Environmental Health, 2013
Purpose Light-at-night exposure can disrupt the human circadian rhythm via clock gene expressions. The circadian rhythm influences antioxidant enzymes' activity and cellular mRNA levels of these enzymes. The employees working based on a shift system adjust to the changes occurring both on the cell level and on the level of the whole organism. Therefore, a question should be answered whether shift work disturbs oxidant-antioxidant balance and/or generates oxidative stress. Methods A cross-sectional study was conducted among nurses selected from the Local Registry of the Chamber of Nurses and Midwives in Lodz: 359 nurses worked daily only and 349 working rotating night shifts. These two groups differed significantly in respect of age (p \ 0.0001), menopausal status (p \ 0.0001), and current smoking habit (p = 0.02). The average total work duration was significantly shorter (12.4 years) in nurses working currently rotating night shifts who worked significantly longer on night shifts than day-workers (26.6 years). Results We found statistically significant higher red blood cell glutathione peroxidase in nurses working on night shifts (21.0 ± 4.6 vs. 20.0 ± 5.0 U/g Hb, p \ 0.009) after adjusting for age, oral contraceptive hormone use, smoking, and drinking alcohol during last 24 h. Statistically significant lower vitamin A and E levels were found in the premenopausal women working in rotating system (0.690 ± 0.238 vs. 0.786 ± 0.262 lg/ml, p \ 0.0001 for vitamin A and 10.93 ± 4.15 vs. 12.78 ± 4.75 lg/ml, p \ 0.0001 for vitamin E). The marker of lipid peroxidation (TBARS concentration) was significantly lower in the premenopausal nurses than postmenopausal ones working day shifts only (2.06 ± 0.76 vs. 2.21 ± 0.80 nmol/ml, p \ 0.038). We observed that erythrocyte GSH-Px activity rose statistically significant in nurses working more night shifts per month (p \ 0.01). Conclusions The results quoted above seem to support the existence of an association between light-at-night exposure and blood glutathione peroxidase activity in female shift workers. Nevertheless, in order to explain the mechanisms of this association, we need more studies.
Serum Level of Cortisol, hsCRP and IL-6 in Depressed Rotational Shift Workers
Thrita Journal of Medical Sciences, 2012
Background: Depression and sleep disorders are more prevalent among rotational shift workers than regular day workers. People with sleep disorders have higher inflammatory and pre-inflammatory cytokines than those in the control group. Objectives: The present study was conducted to investigate serum level of high sensitivity C-reactive protein (hsCRP), Interleukin-6 (IL-6) and cortisol among depressed rotational shift workers at Iran petroleum industry. Materials and Methods: In this cross sectional study, 136 shift workers were studied based on the inclusion and exclusion criteria. Demographic information was collected using a self-administered general questionnaire and depression score was gathered according to 21-question Beck depression inventory. Also, weight and height were measured to calculate body mass index and history of disease was collected based on their occupation profile at health center of Tehran Shahid Tondgoyan oil refinery.
WORK: A Journal of Prevention, Assessment & Rehabilitation, 2019
BACKGROUND:Shift working is unavoidable in many industries with continual material processing such as petrochemical plants. So, the adverse effects of shift working on workers should be seriously considered. OBJECTIVE:This cross-sectional study evaluated occupational fatigue and mental health complaints and their relationship in rotating 8-hour shift workers. METHOD:In this study, 287 shift workers participated. The Multidimensional Fatigue Inventory (MFI-20) and General Health Questionnaire (GHQ-28) were used to evaluate the level of fatigue and mental health, respectively. RESULT:A relatively high prevalence of mental health complaints (particularly social dysfunction) and fatigue (especially general fatigue) were found among the study population. In general, 43.4% of participants reported a mental health problem. A moderate correlation was found between fatigue and mental health (r = 0.58). The stepwise regression model revealed that fatigue was significantly related only to “anxiety and insomnia” and “severe depression”. CONCLUSION:This study revealed that the 8 h shift workers in studied areas are exposed to a considerable risk of mental health and fatigue. So, improving the ergonomics and health aspects of the workplace is recommended to reduce related risk factors.
Human Psychopharmacology-clinical and Experimental, 2007
ObjectiveThe aim of the present study was to investigate the oxidative–antioxidative systems and effects of different antidepressants on these systems in patients with major depressive disorder (MDD).The aim of the present study was to investigate the oxidative–antioxidative systems and effects of different antidepressants on these systems in patients with major depressive disorder (MDD).MethodNinety-six patients with a Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-IV) diagnosis of MDD and 54 healthy controls were included in the study. Plasma malondialdehyde (MDA) levels and susceptibility of red blood cells (RBCs) to oxidation were determined to investigate the oxidative status, plasma vitamin E, vitamin C, serum total carotenoid levels, total antioxidant capacity (TAOC), RBC superoxide dismutase (SOD) and whole blood glutathione peroxidase (GPx) activities were measured to investigate the antioxidative defence before and after 6 weeks of antidepressant treatment.Ninety-six patients with a Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-IV) diagnosis of MDD and 54 healthy controls were included in the study. Plasma malondialdehyde (MDA) levels and susceptibility of red blood cells (RBCs) to oxidation were determined to investigate the oxidative status, plasma vitamin E, vitamin C, serum total carotenoid levels, total antioxidant capacity (TAOC), RBC superoxide dismutase (SOD) and whole blood glutathione peroxidase (GPx) activities were measured to investigate the antioxidative defence before and after 6 weeks of antidepressant treatment.ResultsPlasma MDA levels and susceptibility of RBCs to oxidation were significantly higher in the MDD group compared with the control group. RBC SOD activity was significantly increased in patients with MDD, and furthermore there was a significant positive correlation between the severity of the disease and SOD activity.Plasma MDA levels and susceptibility of RBCs to oxidation were significantly higher in the MDD group compared with the control group. RBC SOD activity was significantly increased in patients with MDD, and furthermore there was a significant positive correlation between the severity of the disease and SOD activity.ConclusionMDD is accompanied with oxidative stress; however, oxidative–antioxidative systems do not seem to be affected by 6 weeks of antidepressant treatment. Copyright © 2007 John Wiley & Sons, Ltd.MDD is accompanied with oxidative stress; however, oxidative–antioxidative systems do not seem to be affected by 6 weeks of antidepressant treatment. Copyright © 2007 John Wiley & Sons, Ltd.
SAGE open medicine, 2018
Major depressive disorder is diagnosed on the basis of patient's self-reported experiences, behavior reported by relatives, and a mental status examination, and yet we do not have any reliable biomarker for this. Mood-regulating pathways are affected by oxidative injury to lipids and cortisol is released into the blood due to stimulation of corticotrophin receptors in the adrenal cortex. Here, we aimed to determine serum levels of malondialdehyde and cortisol in major depressive disorder patients and controls. We collected blood samples from 247 major depressive disorder patients and 248 controls. Serum levels of malondialdehyde and cortisol were measured by ultraviolet spectrophotometry and enzyme-linked immunosorbent assay kit, respectively. We found malondialdehyde levels were significantly higher in patients than controls, with mean ± standard deviation at 4.49 ± 1.37 and 2.87 ± 0.82 µmol/L, respectively, < 0.001. Cortisol levels were also found significantly higher in p...