Anatomical Variants of the Circle of Willis and Brain Lesions in Migraineurs (original) (raw)
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The Journal of Headache and Pain, 2014
Background: The circle of Willis is an important source of collateral blood flow to maintain adequate cerebral perfusion, particularly in the posterior circulation. Some studies report a relationship between incomplete circle of Willis and migraine, whereas other studies show no difference between the prevalence of incomplete circle of Willis in migraineurs and controls. In the present study we compared the prevalence of incomplete circle of Willis in female migraine patients without aura to female healthy non-migraine controls. Using 3-Tesla magnetic resonance angiography we recorded three-dimensional time-of-flight angiograms in 85 female participants (48 migraine patients without aura [median age 28 years] and 37 healthy controls [median age 25 years]). The images were subsequently analysed blindly by a neuroradiologist to detect incomplete circle of Willis.
Incomplete Posterior Circle of Willis: A Risk Factor for Migraine?
Headache: The Journal of Head and Face Pain, 2009
Background.-Migraine is associated with vascular risk factors and white matter abnormalities (WMA). Cerebral hypoperfusion is known to be one mechanism underlying WMA and a few studies have shown that an incomplete circle of Willis (CW) may predispose to cerebral hypoperfusion. This study assessed the relationship between the morphologic characteristics of the CW and migraine.
Circle of Willis variations in migraine patients with ischemic stroke
Brain and Behavior
On behalf of the Dutch acute Stroke Study (DUST) investigators This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
International journal of health sciences
Background: The human brain represents 2% of human body weight. It is supplied by two major arteries, paired internal carotid arteries and vertebral arteries. The arterial circle of Willis forms a polygonal anastomotic channel between two internal carotid artery and two vertebral arteries. The arterial circle is situated at the base of the brain in the interpeduncular fossa. Dr. Thomas Willis who first described the function of arterial anastomosis in 1966. Aim: To study the incidence of arterial variations in circle of willis among migraine patients of Western U.P. Methodology: Present study was conducted in the Department of Anatomy, Santosh Medical College Ghaziabad in collaboration with the Department of Radiodiagnosis, Rama Medical College & Hospital, Ghaziabad and from Dr. O.P Gupta Imaging Centre, Meerut. A total of 132 patients were scanned and 3D TOF sequence has been taken for MRA (BRAIN) examination.3D angiogram was reviewed for variation in brain. Results: The complete c...
Brain structural abnormalities in migraine patients: an observational study
Background: Migraine is a common neurological disorder, characterized by a complex physiopathology. We analyzed brain structural differences in migraine and the possible pathogenetic mechanism underlying this disease.Methods: We assessed brain structure in migraine patients, 14 with aura (MA) and 14 migraine without aura, (MO) compared with health subjects (HS) by using (VBM) approach.Results: Total cerebral GMV showed a significant difference between MA and HS (p=0.03), and between MO and HS (p=0.003). In addition, there was a significative difference trend between MA and MO (p=0.05) groups. We found three clusters of regions which showed significant GMV reduction in MA compared with MO. MA subjects showed a decrease of GMV in 4 clusters if compared with HS, and MO subjects showed a decrease of GMV in 3 clusters if compared with HS. We observed that MA and MO patients had a significant reduction of GMV in the frontal and temporal lobe and the cerebellum, if compared to HS. The bila...
Structural Brain Changes in Migraine
JAMA, 2012
Context-A previous cross-sectional study showed an association of migraine with a higher prevalence of magnetic resonance imaging (MRI)-measured ischemic lesions in the brain.
Evidence for a vascular factor in migraine
Annals of Neurology, 2011
Objective: It has been suggested that migraine is caused by neural dysfunction without involvement of vasodilatation. Because dismissal of vascular mechanisms seemed premature, we examined diameter of extra-and intracranial vessels in migraine without aura patients. Methods: A novel high-resolution direct magnetic resonance angiography imaging technique was used to measure arterial circumference of the extracranial middle meningeal artery (MMA) and the intracranial middle cerebral artery (MCA). Data were obtained at baseline, during migraine attack, and after treatment with the migraine abortive drug sumatriptan (a 5-hydroxytryptamine agonist). Results: We found dilatation of both MMA and MCA during migraine attack (p ¼ 0.001). Sumatriptan administration caused amelioration of headache (p < 0.001) and contraction of MMA (p < 0.001), but MCA remained unchanged (p ¼ 0.16). Exploratory analysis revealed that in migraine attacks with half-sided headache, there was only dilatation on the headache side of MMA of 12.49% (95% confidence interval [CI], 4.16-20.83%) and of MCA of 12.88% (95% CI, 3.49-22.27%) and no dilatation on the nonheadache side of MMA (95% CI, À4.27 to 11.53%) and MCA (95% CI, À6.7 to 14.28%). In double-sided headache we found bilateral vasodilatation of both MMA and MCA (p < 0.001). Interpretation: These data show that migraine without aura is associated with dilatation of extra-and intracerebral arteries and that the headache location is associated with the location of the vasodilatation. Furthermore, contraction of extracerebral and not intracerebral arteries is associated with amelioration of headache. Collectively, these data suggest that vasodilatation and perivascular release of vasoactive substances is an integral mechanism of migraine pathophysiology.
Brain morphologic abnormalities in migraine patients: an observational study
The Journal of Headache and Pain
Background Migraine is a common neurological disorder characterized by a complex physiopathology. We assessed brain morphologic differences in migraine and the possible pathogenetic mechanism underlying this disease. Methods We analyzed brain morphologic images of migraine patients, 14 with aura (MwA) [the mean (SD) age was 42.36 (2.95) years (range, 37–47)] and 14 without aura (MwoA) [the mean (SD) age was 43.5 (3.25) years (range, 39–50)] during episodic attack compared with health subjects balanced (HS) [the mean (SD) age was 42.5 (5.17) years (range, 34–51)]. All subjects underwent a Magnetic Resonance Imaging (MRI) examination with a scanner operating at 3.0 T and voxel based morphometry (VBM) approach was used to examine the gray matter volume (GMV). The statistical analysis to compare clinicl characteristics was performed using unpaired t-test an one-way Anova. Results: Total cerebral GMV showed a significant difference between MwA and HS (p = 0.02), and between MwoA and HS (...