[2-Aryl substituted benzo-anellated 5-ring-heterocycles as potential agents for the cardiovascular system. 2. 1,3-Benzimidazoles] (original) (raw)

PubMed, 1991

Abstract

In the course of investigations on structure-activity relationships of fostedil-and sulmazole-analogously fused 5-membered heterocycles, 1,3-benzimidazoles were obtained by simple cyclisation. In vitro experiments on isolated organs demonstrate markedly positive inotropic effects of some derivatives, whereas others exert both relaxing activity on smooth musculature in vitro and antihypertensive effects in vivo. Moreover they exhibit fungicide properties in vitro.

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