Myofibroblastoma of male breast: report of three cases and review of the literature (original) (raw)

Myofibroblastoma of Male Breast: A Rare Case Report

2022

Myofibroblastoma (MFB) is an extremely rare benign tumour that can arise in various organs, but commonly in the breast. Myofibroblastoma of the breast is a rare benign stromal tumour seen predominantly in men in older age. The gross appearance is that of a well-circumscribed nodule, characteristically small, seldom exceeding 3 cm. Furthermore, myofibroblastoma can arise in extra mammary sites, along the milk-line.. Radiological imaging is nonspecific in MFB, and pathological examination of needle biopsy or surgically resected specimen is necessary for the diagnosis. Surgery is recommended and considered curative without additional treatment; however, patients should be followed-up. One case of MFB of the breast is described here since it is a very rare case and pre operative diagnosis is challenging.

An unusually large myofibroblastoma in a male breast: a case report

Journal of Medical Case Reports, 2008

Introduction: Myofibroblastoma of the breast is a rare benign stromal tumour seen predominantly in men. The gross appearance is that of a well-circumscribed nodule, characteristically small, seldom exceeding 3 cm. We present a case of an unusually large myofibroblastoma, which mimicked a malignant breast tumour.

Male mammary myofibroblastoma: Two case reports and brief review of literature

Molecular and Clinical Oncology

Myofibroblastoma of the breast is a rare benign stromal tumor that occurs in both sexes with a higher prevalence in male breast of older populations. Furthermore, myofibroblastoma can arise in extra mammary sites, along the milk-line. A variety of morphological variants in addition to the classic type have been identified. The differential diagnosis includes both benign and malignant entities that, through the use of clinical and radiological imaging, is difficult to characterize. Histopathological examination and immunohistochemistry are fundamental in the establishment of appropriate management of the disease and avoidance of overtreatment. The present study focuses on two cases of male mammary myofibroblastoma, with a short literature review.

Myofibroblastoma of the breast: two case reports and literature review

Journal of Surgical Case Reports

Myofibroblastoma (MFB) is a relatively rare tumor of the breast parenchyma, which belongs to the family of the ‘benign stromal tumor of the breast’. Two cases of MFB of the breast are described. Radiological imaging is nonspecific in MFB, and pathological examination of needle biopsy or surgically resected specimen is necessary for the diagnosis. Surgery is recommended and considered curative without additional treatment; however, patients should be followed-up.

Breast myofibroblastoma in a young woman: a case report

Annali italiani di chirurgia, 2013

Myofibroblastoma (MFB) is an uncommon benign mesenchymal tumor that may arise in several organs and tissue. Although most of reported cases were located in the breast, it is extremely rare, representing less than 1% of breast tumor. MFB has predominantly seen in elderly men, but some cases have been described in menopausal women. This lesion is a stromal tumor which has many morphologic variants including cellular, collagenized, epithelioid, palisaded, lipomatous, hemangiopericytoma-like, and infiltrant features. Even if its incidence has recently increased due to the mammary screening, only few cases have been reported in Literature and even less in young women. Physical examination discloses a solitary, unilateral, painless, freely movable, usual firm in consistency, non-tender nodule. Imaging investigations usually are not specific to establish the right diagnosis. Furthermore, findings from Fine-Needle Aspiration (FNA) may be confusing and nonspecific, making diagnosis of MFB po...

Myofibroblastoma of the Breast

Journal of Breast Health, 2015

This study aimed presenting a case of a 64-year-old woman with a rare diagnosis of myofibroblastoma (MFB). MFB is one of the rare, benign, spindle-like stromal tumors arising from the connective tissue of the breast. MFBs are often confused with fibroadenomas and hamartomas because of their benign characteristic appearance on breast imaging and are diagnosed after excisional biopsies. Their differential diagnosis with malignant neoplasia of the breast is important because of their wide morphological spectrum. Our case also demonstrated a breast mass with benign imaging characteristics and a needle core biopsy revealing a benign, spindle-like stromal tumor. The pathological examination performed after the excision of the lump demonstrated a collagenous-/ fibrous-type MFB. This case report emphasizes the rare but important place of MFB variants of the breast in the differential diagnosis of breast mass.

A Case Report of Successful Treatment of Mammary Myofibromyoblastoma in a Male Patient

Journal of Current Surgery, 2019

Myofibroblastoma (MFB) is an extremely rare benign tumor that can arise in various organs, but commonly in the breast. Albeit it is a benign tumor, the diagnosis is frequently challenging with insurmountable difficulties as it might be erroneously diagnosed as a malignancy. Herein we are reporting a large-sized MFB presented as a non-tender, firm mass which interestingly was adherent to the skin and was initially thought as cancer. The patient underwent a wide local excision and histology confirmed MFB, and had no evidence of recurrence up to 8 months post-operatively.

Epithelioid Myofibroblastoma in an Old-Male Breast: A Case Report with MRI Findings

Case Reports in Radiology, 2015

Myofibroblastoma of the breast (MFB) is a very rare benign stromal tumor. In recent years, increase in mammographic screenings has resulted in increased diagnosis of MFB. Most cases are old males and postmenopausal women. MFB may be confused as malignant, clinically, morphologically, or by imaging. Immunohistochemistry is essential for final diagnosis in these cases. We report a case of a pathologically diagnosed MFB in an 80-year-old male patient who had coexisting prostate cancer and describe its imaging characteristics, especially magnetic resonance imaging (MRI). In this paper, histopathological and MRI findings of the MFB were discussed.