Route‐Related Variation in the Immunogenicity of Killed Salmonella enteritidis Vaccine: Role of Antigen Presenting Cells (original) (raw)

Microbiology and Immunology, 1989

Abstract

In order to assess the role of the route of immunization on the immunogenicity of killed Salmonella vaccine, mice were immunized with killed S. enteritidis by intraperitoneal (i.p.) and intradermal (i.d.) routes. Whereas the former was non‐immunogenic, the i.d. immunization generated an excellent delayed‐type hypersensitivity response; further, i.p. immunization could even suppress the subsequent i.d. immunization. Since the peritoneal macrophages (MO) are known to be particularly low in Ia or MHC‐class II antigens, so essential for antigen presentation, the non‐immunogenicity by i.p. route was thought to be due to their poor presentation efficiency. Poly I: poly C, an interferon inducer, is known to enhance the MHC‐class II expression; hence effect of poly I: poly C treatment on the immunogenicity of the killed vaccine by i.p. route was tested and indeed the non‐immunogenicity was corrected. Poor efficiency of presentation of S. enteritidis antigen by peritoneal cells and its impro...

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