Study of basal cell carcinoma and its histopathological Study of basal cell carcinoma and its histopathological variants variants (original) (raw)
Related papers
Histopathological Spectrum of Basal Cell Carcinoma-7 Years Retrospective Study
SSR Institute of International Journal of Life Sciences, 2020
Background: Basal cell carcinoma is the most common malignant tumour of the skin worldwide. The objective was to find out the age and sex incidence of basal cell carcinoma in patients attending the outpatient department of dermatology and to find out the various clinical and histopathological features of basal cell carcinoma. Methods: It was a retrospective study carried out in a NABH, NABL and JCI accredited hospital, New Delhi, India. Patients with a clinical diagnosis of basal cell carcinoma were included in the study after thorough history, clinical examination, routine and special investigations like skin biopsy. Results: Out of 20 patients with basal cell carcinoma 6 were males and 14 were females with a male to female ratio of 1:2.33. Most commonly affected age group was 51-70 years (70%). Distribution of BCC in our study was confined to head and neck area. Most common morphological subtype encountered in this study was nodular/nodulo-ulcerative BCC (70%), followed by the pigmented type (25%) and superficial BCC (5%). The most common histological variant observed in the present study i.e. nodular type (55%), followed by the pigmented variant (25%), adenoid (5%), basosquamous (5%), superficial BCC (5%) and BCC with sebaceous differentiation (5%). Conclusion: This study highlights a paradoxically increasing trend of BCC with female predilection. Early detection and treatment of lesions are crucial to decrease the functional and cosmetic disfigurement and also this study highlights the importance of improving awareness among general practitioners, public health workers and the general population.
A Clinical Study of Basal Cell Carcinoma
Medical Archives
Introduction: Basal cell carcinoma (BCC) is a non-melanocytic skin malignancy arising from basal cells of epidermis or follicular structures. Etiology of BCC is a multifactorial combination of genotype, phenotype, and environmental factors. There are several clinical variants of BCC including nodular, cystic, superficial, morphoeic, keratotic, pigmented and micronodular. Aim: The aim of our study was to analyze the recent clinical trends of basal cell carcinoma by reviewing a single institution's experience. Methods: Total number of 422 patients clinically diagnosed with basal cell carcinoma were included in the study. Data on age, gender, skin type, personal and family history, duration of disease, localization of lesions, clinical type of lesions, and recurrence rate were collected and analyzed. The data were statistically evaluated. Results: More than 80% of all BCC's were located on sun-exposed skin areas (p<0.05).The male /female ratio was 1:0.92. The nodular BCC was the most frequent type (59.2%), followed by the superficial (16.1%), pigmented (15.2%) and morphoeic (9.5%) types. The nodular and pigmented types were predominant located on the head and neck, whereas the trunk was the most common location for the superficial type (p<0.05). The tumor is commonly found in concomitance with skin lesion related to chronic sun exposure, such as actinic keratoses, solar lentigines and facial telangiectasia. During this study period, 41 cases showed recurrence of the cancer as the overall recurrence rate was 9.7%. There were no cases with metastasis or fatal outcome. Conclusions: The factors related to the development of BCC were older age and exposure to ultraviolet rays both in recreational and in occupational form. The prevention of BCC is based on the knowledge of risk factors, early diagnosis and treatment, particularly in susceptible populations.
Basal cell carcinomas - clinical-evolutional and histopahotologic aspects
Current health sciences journal, 2009
Basal cell carcinoma (BCC) is the most frequent cutaneous tumour. Having as aim the identification of the clinical-evolutional and histopathologic aspects of the basal cell carcinomas, we have undertaken a retrospective study for a period of 5 years, from 1st January 2004 to 31st December 2008, on 706 patients interned in the Dermatology Clinic of Craiova, whom indicated 738 tumours. A clinical data was drawn for the patients, containing the identification data, environment, profession, cancer localisation and history of the disease, clinical and histopathologic diagnosis. Results. In our lot, the most numerous cases were of pearly BCC (33.6%), nodular BCC (22.2%), respectively scar plane BCC (13.1%).Regarding the histopathologic type, the repartition was as it follows: solid BCC (33.7%), polymorph (19.2%), adenoid (13.1%), keratinised (11.8%), superficial (7.0%), cystic (3.8%), pigmented (3.8%), scleroderma form (2.2%), in situ (1.4%).
Clinicopathological study of basal cell carcinoma over a period of nine years-from Uttar Pradesh
IP Innovative Publication Pvt. Ltd., 2018
Introduction: Basal cell carcinoma is the most common type of skin cancer and occurs mostly in the head and neck region in middle age to elderly people. It has varied clinical presentation and also many morphologic/histopathologic subtypes. Aim of the Study: To study the spectrum of basal cell carcinomas in our institute over a nine year period. Materials and Methods: This was a prospective study carried out at Subharti Medical College, Meerut, Uttar Pradesh, over a period of nine years. All the basal cell carcinomas reported during this period were studied for clinical presentation, demographic details, anatomical location of tumor, macroscopic and microscopic appearance. Results: A total of 28 cases of BCC were reported. The patient age ranged from 14 to 85 years and the male to female ratio was 2.1:1. Most of the cases occurred over 40 years and all the tumors occurred in the facial region. Clinically, ulcerative and nodular presentation was more common. One case of nevoid BCC syndrome was also seen. Conclusion: Basal cell carcinoma commonly occurs in the face region and its incidence increases with advancing age. It has varied clinical presentations and histologic subtypes. Early diagnosis gives better prognosis. Basal cell carcinoma in a young person or child should be evaluated for nevoid BCC syndrome. Keywords: Basal cell carcinoma, Histologic subtypes of BCC, Nevoid BCC syndrome.
Study of Basal Cell Carcinoma and Its Morphological Spectrum
2019
Original Research Article Introduction: Basal cell carcinoma is the most common skin malignancy worldwide with a predilection towards sun exposed areas especially head and neck areas. It is a slow growing tumour with propensity for local invasion, however metastasis is seldom seen. The histopathological variants seen in BCC are nodular, micronodular, cystic, superficial, pigmented, adenoid, infiltrating, sclerosing, keratotic, infundibulocystic, metatypical, basosquamous etc. Aim: The aim was to study morphological spectrum of BCC cases in a tertiary care hospital in southern region of New Delhi. Materials and Methods: This study was a retrospective analysis in which nine cases of BCCs were included. Result: The mean age of presentation was 68.4 years. There was female preponderance (77%). Face was the most common location (88%) with cheek being the commonest and the ulceration was the most common clinical presentation (66.6%). Among the nine cases of BCC’s, 33.3% were solid, 22.2% ...
Journal of Forensic Medicine, 2021
Basal cell carcinoma is most common type of non-melanotic skin cancer. Causative agents are UV and ionizing radiation and chemicals. Nodular, pigmented, superficial, cystic and infiltrative are major subtypes. It is mainly treated by excision surgery in the form of wide local excision and reconstruction is done by various flaps. In our study 10 patients were included and found that carcinoma is commoner in old age female patients and mainly near right canthus of eyeball; treated with surgery which is well tolerated by all the patients.
Journal of Evolution of Medical and Dental Sciences, 2017
BACKGROUND Basal Cell Carcinomas (BCC) are the most common amongst the non-melanoma skin cancers. The existing literatures on BCC are scant in India. BCC are rare in dark skin, because of the inherent photoprotection of melanin and melanosomal dispersion. Risk factors include UV light exposure, ionising radiation, exposure to arsenic, mutations. Although, BCCs have excellent prognosis, if left untreated it causes significant disfigurement and invasion of surrounding tissues. The present study was aimed to evaluate the risk factors, clinical and histopathological spectrum of BCC in Eastern Andhra Pradesh. The objectives were to analyse clinical data with respect to age, sex, occupation, sunlight exposure, anatomical location, size of the lesion, morphological and histopathological subtypes. MATERIALS AND METHODS The present study was conducted in DVL Department, Rangaraya Medical College, Kakinada, Andhra Pradesh. A prospective analysis of 40 cases of BCC in a period of 3 years: January 2014-December 2016 diagnosed and confirmed histopathologically. RESULTS Out of 40 cases, 65% were females. History of exposure to the sunlight was observed in all the cases. One case of 18-year-old female with xeroderma pigmentosum with BCC was seen. Sites noted were forehead (22.5%), ear, nose and infraorbital region (each 15%). Clinically, pigmentation was evident in 19 cases. Morphological types seen were ulcerative (55%), nodular (37.5%), swelling/cyst (5%) and morpheaform (2.5%). Histological types are nodular (57.5%), pigmented (25%), adenoid (7.5%), keratotic (2.5%) and with sebaceous differentiation (2.5%). Recurrent BCCs were seen in two cases. CONCLUSION This study highlights the role of sunlight and farming as aetiological risk factors of BCC and female preponderance. Forehead is the common site of presentation. Nodular and pigmented types (subtype of nodular variant) were common. Early detection of BCC lesions, particularly of small size (< 2 cm) helps in preventing further recurrences.
Histopathologic variants of basal cell carcinoma correlation with sex, age and localization
Journal of medical …, 1999
basal cell carcinomas (BCC) of a total of 323 investigated specimens were diagnosed. The incident rate varies from 92 to 114 BCC per 100,000 inhabitans in the Split region. The sex ratio in material is 1,2:1 in favor of males. The frequence of BCC increases with the advanced age in both sexes with the peak in the age group from 70 to 79 years. The most frequent location in both sexes is the nose followed by cheeks and trunk. Statistic analysis showed a significantly higher occurrence of BCC in temporal region in the males and perioral region in the females; respectively. The solid variant is the most frequent followed by superficial multicentric and solidadenoid. Pure variants are found in 83.1% specimens, and mixed variants in 16.9%. Solid and adenoid variants are the most frequent on the nose and cheeks. According to statistics cystic variant is significantly higher on the forehead, and morpheic variant on the nose. Superficial multicentric variant is statisticaly more frequent on the trunk than on other locations. All specimens were reexamined and histopathologic variants were obtained. Over 2000 data are comprised which is a sufficient examination sample. In programs such as SPSS, and Graph master ver 1,12, Win95, MO'97 (Word, Excel, Access) on Pentium II 200 MHz, floppy, 64 MB RAM, HDD 2,1 GB, CD x24, HP LJet 6L, a comprehensive analysis has been performed.
Age and Site Prevalence Oe Histologic Subtypes Oe Basal Cell Carcinomas
International journal of …, 1995
Background. Basal cell carcinomas (BCC) are the most frequently diagnosed skin cancers. The relationships between some clinical parameters, such as sex, age, and location of the tumor, and the histologic patterns play an important role as factors predictive of recurrence and treatment implications. Methods. A total of 693 patients with BCC, divided according to sex, age, and location of the tumor were studied. The histologic patterns considered were nodular, superficial, and morpheiform BCC and fibroepithelioma. The correlation between clinical and histologic parameters was analyzed. Results. All histologic patterns considered were most commonly represented in the 7th and 8th decades. There were no sex differences. A prevalence of a superficial pattern for sununexposed areas and of a nodular pattern for sun-exposed areas was observed. The morpheiform pattern showed no correlation with any body site. The fibroepithelioma showed an absolute prevalence for the lumbosacral region.
Journal of Babol University of Medical Sciences, 2023
Background and Objective: Basal cell carcinoma is the most common human malignancy that has been increasing in recent years. The aim of this study is to determine the demographic and histopathological pattern of this malignancy in the pathology departments of state hospitals in Babol from 2013 to 2020. Methods: In this retrospective study, after reviewing the existing files with the final diagnosis of basal cell carcinoma from 2013 to 2020, the patients' information including age, gender, lesion location and microscopic subgroup were recorded and analyzed. Findings: In this study, 367 cases were obtained from Shahid Beheshti and Shahid Yahyanejad Hospitals in Babol with the diagnosis of basal cell carcinoma. The mean age of people in both genders was 67±10.89 years. 69% of the samples were men and 31% were women (p<0.001). The highest frequency was from the scalp area (134 samples) and the lowest frequency was related to the chest (3 samples). The most common histopathology subtype was nodular type and the rarest types were metatypical and clear cell carcinoma. A statistically significant relationship was observed between the location of the sample and gender (p=0.023); the cheek in men and the nose in women were more common than the other gender. The highest incidence was seen in 2017 with 83 cases, which was a significant increase compared to the previous year. Conclusion: Based on the results of this study, the high incidence of basal cell carcinoma in the head and face area of elderly people, especially men, reveals the need to inform high-risk communities and to be more familiar with therapists, especially dentists who are in close eye contact with the face.