Antineutrophil Cytoplasmic Antibodies (Anca): The Relationship Between Sex, Age and Antigenic Specificities (original) (raw)

This paper explores the relationship between sex, age, and antigenic specificities in antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitides (AAV). It discusses the classification of AAV, the role of ANCAs in pathogenesis, and highlights the importance of understanding ANCA positivity in relation to disease activity and therapeutic decision-making. While significant advances have been made in understanding the implications of ANCAs, the utility of their measurement for predicting disease relapse remains controversial.