Association of Serum Lipid Profile and Chronic Periodontitis: A Case Control Study (original) (raw)
Related papers
SERUM LIPID LEVELS IN PERIODONTITIS PATIENTS: A CASE-CONTROL STUDY
International Journal of Pharmacy and Pharmaceutical Sciences, 2018
Objective: We aimed to evaluate serum lipid levels in periodontitis patients and compared with healthy subjects. Methods: A case-control study was conducted among 30 participants in the age group of 35-60 y, including 15 subjects in case group with community periodontal index (CPI) score of ≥2 and 15 subjects in the control group with a CPI score of ≤ 1 based on their periodontal status. Fasting blood samples were taken for measurement of lipid profiles, including total cholesterol, triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL) using an enzymatic method. Odds ratio and independent t-test at *p=0.05 significance level were calculated. Results: Periodontitis patients were 4.1 times at risk to have high triglyceride, 1.3 times at risk to have high total cholesterol and 0.3times at risk to have higher HDL. Independent t-test showed higher total cholesterol/HDL ratio (*p=0.033) and lowered HDL levels (*p=0.027) in periodontitis patients. Conclusion: Periodontitis group has significantly higher total cholesterol/high-density lipoprotein ratio and lower high-density lipoprotein levels when compared to the healthy group.
Aim: To compare the serum lipid levels in systemically healthy subjects with and without periodontal disease and to correlate the results between hyperlipidemia and periodontitis. Material and Methods: A total of 80 subjects of both sexes (42 males and 38 females), in the age group of 35-55 yrs were divided into two groups of 40 each as study and controls. All the patients were evaluated for serum cholesterol, serum triglycerides, LDL and HDL cholesterol. Variables related to high cholesterol levels, including age, sex and body mass index were also evaluated. The dental parameters recorded consisted of probing pocket depth (PPD), community periodontal index (CPI) and periodontal disease index (PDI). Results: Total cholesterol, LDL cholesterol and triglycerides were marginally increased in study group but were not found to be statistically significant (p=0.106, p=0.100 & p=0.199 respectively). Triglycerides showed a positive correlation with CPI and PDI after adjusting for age and disease. However, the correlation of triglycerides with PDI was minimal compared to the correlation of triglyceride with CPI. Conclusion: The findings of this study showed that there was no significant relationship between periodontal disease, regardless of its intensity, and blood l ipid levels in the study population.
Association between Chronic Periodontitis and Serum Lipid Levels with Its Risk to Atherosclerosis
2015
Background: Regarding the high prevalence of hyperlpidaemia, which is one of the major risk factors of cardiovascular disease, and uncertain reports about the relation between periodontal disease and serum lipid profile, this study was conducted to assess this relation. The historical cohort study was conducted on 45 cases including 30 persons with chronic periodontitis as case group, and 15 healthy subjects as control group. Both groups had the same age and weight ranges, sex and diet, without any periodontal treatment history in the past six months, underlying systemic disease such as diabetes, anti-hyperlipidemic drugs or active tobacco smoking history. Low density lipoprotein (LDL), High density lipoprotein (HDL), Triglyceride (TG) and total cholesterol (CHOL) were measured by direct enzymatic assay. TG level was 116.713+/-30.485 mg/dl in control group and 166.197+/-69.332 in case group (P = <0.001). In control group, LDL was 90.347+/-21.565 and in case group, 105.813+/-19.19...
International Journal of Dental Hygiene, 2009
Abstract: Background: The search for cellular mechanisms linking periodontitis to changes in systemic health has resulted in the evolution of a new area of lipid research. So far the causality and possible pathways of the association between periodontal disease and cardiovascular disease is obscure.Method: A total of 120 subjects were included in the study with 30 subjects in each of the following groups: healthy group (A), chronic periodontitis group (B), coronary heart disease (CHD + periodontitis group) (C) and CHD − periodontitis group (D). All subjects underwent oral examination and their Gingival Index, Oral Hygiene Index, Periodontal Disease Index scores and attachment loss were recorded. Two millilitres of fasting venous blood sample was drawn and tested for the level of total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL) and triglyceride level.Results and Conclusion: The results revealed no significant difference with respect to the lipid profile levels between the four groups. Interpreting the results of the study, periodontal disease did not cause an increase in total CHL, LDL or triglyceride levels or a decrease in the HDL levels in an otherwise systemically healthy individual or in a CHD patient. Periodontitis in a CHD patient did not seem to exacerbate the destruction of periodontal tissue. Higher triglyceride levels did not have any correlation with the severity of attachment loss in a periodontitis subject.
Estimation of Serum Lipid Levels in Chronic Periodontitis Patients: A Case-Control Study
International journal of current research and review, 2016
Aims and Objectives: Hyperlipidemia refers to abnormally elevated levels of lipids and/or lipoproteins in the blood. Elevated serum cholesterol is a modifiable risk factor that is associated with a cardiovascular disease (CVD) with an estimated 4.4 million deaths each year. A positive association between serum triglyceride concentration and risk of coronary heart disease has been observed in many case-control studies. Infection such as periodontitis causes bacteremia and/or endotoxemia producing a cytokine cascade that leads to increased levels of serum pro-inflammatory cytokines. These molecules promote enhanced lipogenesis, increased lipolysis, and reduced lipid clearance resulting in hyperlipidemia. Hence the aim of the study is to estimate the serum lipid levels in chronic periodontitis patients. Materials and Methods: 100 subjects were screened for the study and were grouped as experimental (50 subjects with chronic periodontitis) and control (50 systemically healthy subjects)....
2019
Background: Periodontitis affects at least 72% of Indonesian community according to Indonesian Basic Health Research (Riskesdas) in 2018. Periodontitis is considered as localized inflammation. However, the condition leads to systemic change. The recognition of systemic change was observed in lipid levels by several earlier studies. This study aimed to examine the association between lipid level and chronic periodontitis and healthy periodontal status in productive age. Subjects and Method: This was a cross-sectional study conducted in a company clinic, in 2019. A total of 120 patients were selected consisting of 60 patients diagnosed with chronic periodontitis and the 60 patients with healthy periodontal status. The data of periodontitis patients were obtained from medical checkup. Data of lipid levels included total cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol. The data were analyzed by a multiple linear regression. Results: Patients with chronic periodontitis showed higher LDL cholesterol (p<0.001) and triglycerides (p=0.003) than patients with normal periodontal status. Total cholesterol was higher in patients with chronic periodontitis than healthy periodontal status (p<0.001). The difference in HDL cholesterol was statistically non-significant between patients with chronic periodontitis and healthy periodontal status (p=0.963). Conclusion: Lipid level can be an indicator of periodontal disease and give more information to perform higher quality of examination. However, more studies are needed to strengthen the evidence for improving the medical checkup coverage.
Association between Chronic Generalized Periodontitis and Hyperlipidemia
IOSR Journals , 2019
OBJECTIVES: The objectives of the study were (1)To assess serum lipid levels among healthy subjects. (2) To assess serum lipid levels among subjects with chronic generalized periodontitis. (3) To compare the serum lipid profile among healthy subjects with that of patients having periodontitis. METHODS: A cross sectional study comprising of 50 subjects, 25 subjects with chronic periodontitis and 25 healthy subjects (30-50 years). Serum lipid level (HDL,LDL,VLDL,TGL,TC) of all subjects were measured and compared. RESULTS: The mean difference between total cholesterol, triglyceride, HDL, VLDL and LDL values of test and control groups are 14.5 (p<0.02) 11.1 (p<0.038) , 2.2 (p<0.784), 2.23 (p<0038.), and 7.96(p<0.046) respectively as compared to the controls. Results obtained in this study showed significant association between pronounced alterations in lipid profile of patients with generalized chronic periodontitis as compared to the healthy control groups. CONCLUSION: The present study suggests that Plasma lipid levels significantly correlates with chronic periodontitis and hyperlipidemia.
Association between periodontal disease and plasma levels of cholesterol and triglycerides
Colombia Medica
Objective: untreated periodontal disease seems to cause low grade systemic inflammation and blood lipid alteration leading to increased cardiovascular disease risk. To start testing this hypothesis in colombian patients, a multicentre study was conducted including the three main state capitals: bogota, medellin and cali. Methods: in this study 192 (28.4%) advanced and 256 (37.8%) moderate periodontitis patients were investigated for socio-demographic variables, city of precedence, periodontal parameters, smoking, red complex periodontopathic bacteria, serum antibodies against porphyromonas gingivalis and aggregatibacter actinomycetemcomitans and blood lipids including total cholesterol, hdl, ldl and triglycerides (tg). Those parameters were compared to 229 (33.8%) controls having periodontal health or gingivitis. Results: advanced periodontitis had worst periodontal indexes, than moderate periodontitis and controls. Interestingly, higher hdl and tg levels were present in periodontit...
Serum lipid levels in patients with periodontal disease. A meta-analysis and meta-regression
Journal of clinical periodontology, 2017
Several papers have considered the potential relationship between periodontitis and lipid parameters. The present systematic review, meta-analysis and meta-regression study focused on investigating whether serum lipid parameter levels were elevated in patients with periodontal disease (PD) (without altered systemic conditions) in comparison with periodontally healthy subjects. Eligible studies were those with data about serum lipid parameter levels in non-smoking subjects with and without chronic periodontitis, who are generally healthy and not taking any medication for dyslipidemia. Mean differences and 95% confidence intervals for total cholesterol, triglycerides, low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol were obtained from all the selected studies. 19 publications were included for meta-analysis. Participants with chronic periodontitis presented significantly higher serum levels of LDL and triglycerides (p=0.003 and p<0.0001, resp...