Efficient Synthesis of Salicylates by Catalytic [3 + 3] Cyclizations of 1,3-Bis(silyl enol ethers) with 1,1,3,3-Tetramethoxypropane (original) (raw)

Salicylic acid derivatives are prevalent in nature and play a significant role in medicinal chemistry. Traditional synthetic routes to these compounds face limitations, particularly due to regioselectivity issues and starting material availability. This research introduces a novel catalytic [3 + 3] cyclization of 1,3-bis(silyl enol ethers) with 1,1,3,3-tetramethoxypropane, offering an efficient and mild method to synthesize functionalized salicylates. The reactions yield products that are not easily obtainable through existing methodologies, highlighting the potential of this catalytic approach in organic synthesis.