Ranolazine in Preventing Ventricular Fibrillation During Aortic Valve Replacement in Patients with Low Ejection Fraction: A Single-Centre Retrospective Study (original) (raw)
2020, Journal of surgery and research
Objectives: Aortic valve replacement (AVR) is often associated with intraoperative ventricular fibrillation (VF) complicating early postoperative outcomes. Ca 2+ triggering mechanisms induced by ischemia-reperfusion injury have been implicated as possible causes of this arrhythmia, however, the exact mechanisms remain unclear. The aim of this study was to investigate the role of late sodium current inhibition by ranolazine (RAN) in preventing VF in these patients. Methods: We retrospectively examined 53 patients with aortic stenosis or insufficiency, receiving either
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