A Cardiovascular Occlusion Method Based on the Use of a Smart Hydrogel (original) (raw)

ARTIFICIAL EXTRACELLULAR HYDROGEL MATRIX FOR TREATMENT OF MYOCARDIAL INFARCTION

Artificial extracellular hydrogel matrix as a treatment for myocardial infarction, 2021

The review shows the mechanism of the onset of myocardial infarction and describes promising methods of low-invasive treatment and prevention of this disease using hydrogels (tissue sealants). As additional information for series of articles about medicinal hydrogels adhesives and tissue sealants (see www.patreon.com/posts/50914867)

Biocompatibility and Delivery of a Hydrogel Barrier for the Prevention of Postsurgical Cardiac Adhesions

2018

Author(s): Burdick, Austin | Advisor(s): Christman, Karen L | Abstract: Previous research into the problem of postsurgical cardiac adhesions has produced a hydrogel barrier that can be applied to the surface of the heart, preventing the formation of adhesions in the weeks following trauma during surgery. When developing this type of gel for clinical translation, two issues that must be addressed are the biocompatibility of the material as well as a method of hydrogel delivery to the tissue surface. Previous research yielded a hydrogel made from poly(ethylene glycol) functionalized with aldehyde, aminooxy and dopamine groups. Cell viability is reduced in culture treated with this material due to the inclusion of dopamine. Examination of the hydrogel in culture through fluorescence microscopy and spectrophotometry indicate that this is primarily due to oxidative stress, demonstrated by increased levels of hydrogen peroxide and lipid peroxidation. However, metabolic and morphological a...

Local Use of Hydrogel with Amiodarone in Cardiac Surgery: Experiment and Translation to the Clinic

Gels

The objective of this study was to study the use of the hydrogel biopolymer based on sodium alginate (“Colegel”) with a drug substance—amiodarone—for the prevention of postoperative atrial fibrillation (POAF) in cardiac surgery. The experimental part of the study was performed on 46 rabbits. Five groups were formed: in the first group, the dose of amiodarone in hydrogel was 1 mg; in the second group—3 mg; in the third group—6 mg; in the fourth group, hydrogel was used without amiodarone; in the fifth group, 60 mg amiodarone was administered intravenously. The animals from each group were removed from the experiment for the pathomorphological study of the heart after 3, 7 and 14 days. The studied endpoints were: the heart rate control; the development of the blockades of the conduction system of the heart; and the development of inflammation according to laboratory pathomorphological studies. The translational clinical part involved a randomized clinical trial which included 60 patie...

Nanomaterial-based hydrogels for coronary interventions: a mini review

Mini-invasive Surgery , 2020

Myocardial infarction (MI) has become a major health concern these days. Elevated levels of cholesterol due to improper diet cause severe damage to human health, resulting in the narrowing of blood vessels leading to MI. Different approaches have been used based on surgical and non-surgical treatments for these blockages to cure MI. In this regard, injectable and non-injectable hydrogel-based percutaneous coronary intervention has shown promising applicability for the treatment of cardiac damage and its repair. In this report, we summarize a few hydrogels based on natural polymers such as chitosan, alginate, polyethylene glycol and extracellular matrices to be used for percutaneous coronary intervention in the treatment of MI. Their structure, biological properties and biocompatibilities are discussed, and their existing challenges are also detailed. In addition, the probable solutions to overcome certain set backs are also highlighted.

Effects of hydrogel injection on borderzone contractility post-myocardial infarction

Biomechanics and modeling in mechanobiology, 2018

Injectable hydrogels are a potential therapy for mitigating adverse left ventricular (LV) remodeling after myocardial infarction (MI). Previous studies using magnetic resonance imaging (MRI) have shown that hydrogel treatment improves systolic strain in the borderzone (BZ) region surrounding the infarct. However, the corresponding contractile properties of the BZ myocardium are still unknown. The goal of the current study was to quantify the in vivo contractile properties of the BZ myocardium post-MI in an ovine model treated with an injectable hydrogel. Contractile properties were determined 8 weeks following posterolateral MI by minimizing the difference between in vivo strains and volume calculated from MRI and finite element model predicted strains and volume. This was accomplished by using a combination of MRI, catheterization, finite element modeling, and numerical optimization. Results show contractility in the BZ of animals treated with hydrogel injection was significantly h...